Enhancement of immune responses by 4-1bb-binding agents
First Claim
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1. A method of generating an enhanced immune response in a subject, the method comprising administering to the subject:
- (a) an immunogenic stimulus, wherein the immunogenic stimulus comprises a polypeptide and does not comprise a tumor cell; and
(b) an agonistic antibody that binds to 4-1BB.
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Abstract
This invention features methods of enhancing immune responses in mammalian subjects and in vitro methods of enhancing the response of a T cell. Also embodied by the invention are methods of receiving and preventing the induction of energy in T cells.
40 Citations
28 Claims
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1. A method of generating an enhanced immune response in a subject, the method comprising administering to the subject:
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(a) an immunogenic stimulus, wherein the immunogenic stimulus comprises a polypeptide and does not comprise a tumor cell; and (b) an agonistic antibody that binds to 4-1BB. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An in vitro method of activating a T cell, the method comprising:
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(a) providing a cell sample comprising a T cell; and (b) culturing the cell sample with an immunogenic stimulus and an agonistic 4-1BB-binding agent.
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14. A method of preventing induction of energy or of reversing anergy in a T cell, the method comprising contacting the T cell with:
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(a) an immunogenic stimulus, wherein the immunogenic stimulus comprises a polypeptide and does not comprise a tumor cell; and (b) an agonistic antibody that binds to 4-1BB. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification