Method of treating depression, mood disorders and anxiety disorders using neuromodulation
First Claim
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1. A method of treating a mood or anxiety disorder in a patient comprising:
- implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in or in direct contact with neural tissue of the gray and white matter inferior to the corpus callosum and posterior to the anterior most portion of the genu of the corpus callosum;
coupling the lead to a pulse generator;
generating electrical pulses using a pulse generator;
conducting the electrical pulses from the pulse generator through a stimulation lead; and
applying the electrical pulses to stimulate neural tissue of the gray and white matter inferior to the corpus callosum and posterior to the anterior most portion of the genu of the corpus callosum of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the mood or anxiety of the patient.
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Abstract
The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.
150 Citations
28 Claims
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1. A method of treating a mood or anxiety disorder in a patient comprising:
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implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in or in direct contact with neural tissue of the gray and white matter inferior to the corpus callosum and posterior to the anterior most portion of the genu of the corpus callosum; coupling the lead to a pulse generator; generating electrical pulses using a pulse generator; conducting the electrical pulses from the pulse generator through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the gray and white matter inferior to the corpus callosum and posterior to the anterior most portion of the genu of the corpus callosum of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the mood or anxiety of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of treating depression, mood disorder and/or anxiety disorder in a patient comprising:
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implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in or in direct contact with neural tissue of the gray and white matter inferior to the rostrum and genu of the corpus callosum and about 20 to about 40 mm anterior to the anterior commissure; coupling the lead to a pulse generator; generating electrical pulses using a pulse generator; conducting the electrical pulses from the pulse generator through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the medial gray and white matter inferior to the rostrum and genu of the corpus callosum and about 20 to about 40 mm anterior to the anterior commissure of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the depression, mood disorder and/or anxiety disorder of the patient. - View Dependent Claims (17, 18, 19, 20, 21)
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22. A method of treating depression, mood disorder or anxiety disorder in a patient, comprising:
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implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in neural tissue about 0 mm to 10 mm below the intra-commissural line, about 2 mm to 14 mm from midline and about 20 to about 40 mm anterior to the anterior commissure; coupling the lead to a pulse generator; generating electrical pulses using the pulse generator; conducting the electrical pulses from the pulse generator through the stimulation lead; and applying the electrical pulses to stimulate the neural tissue of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the depression, mood disorder or anxiety disorder of the patient. - View Dependent Claims (23, 24, 25)
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26. A method of treating depression, mood disorder or anxiety disorders in a patient, comprising:
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implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in direct contact with or directly in the subcallosal gyrus area including the surrounding white matter; generating electrical pulses using an implantable pulse generator (IPG) that is implanted within the patient; conducting the electrical pulses from the IPG through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the subcallosal gyrus area including the surrounding white matter of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the depression, mood disorder and/or anxiety disorder of the patient. - View Dependent Claims (27)
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28. A method of improving a patient'"'"'s appetite, comprising:
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implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in direct contact with or directly in the subcallosal gyrus area including the surrounding white matter; generating electrical pulses using an implantable pulse generator (IPG) that is implanted within the patient; conducting the electrical pulses from the IPG through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the subcallosal gyrus area including the surrounding white matter of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively improves the patient'"'"'s appetite.
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Specification