Antimicrobial nanoemulsion compositions and methods

• US 7,655,252 B2
• Filed: 06/25/2002
• Issued: 02/02/2010
• Est. Priority Date: 04/28/1999
• Status: Expired due to Term

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Hamouda, Tarek, Baker, James R. Jr., Myc, Andrzej, Shih, Amy
• Primary Examiner(s): Fubara; Blessing M
• Application Number:
  US10/179,547
• Publication Number:
  US 20100003330A1
• Time in Patent Office: 2,779 Days
• Field of Search: 214/642, 214/537, 214/937, 214/938, 424/40, 424/401, 424/450, 424/489, 424/404, 424/405, 424/400
• US Class Current: 424/405
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/21 Emulsions characterized by droplet sizes below 1 micron
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.

Claims

1. A pharmaceutical composition consisting of:

an oil-in-water nanoemulsion, or a dilution thereof, wherein said nanoemulsion consists of;

a) about 5% by volume surfactant, wherein said surfactant is selected from the group consisting of polyoxyethylenesorbitan monolaurate and polyoxyethylenesorbitan monooleate;

b) about 8% by volume ethanol;

c) about 64% by volume oil;

d) about 1% by volume cetylpyridinium chloride;

e) distilled water; and

f) an interaction enhancer.

2. The pharmaceutical composition of claim 1, wherein said distilled water is sterile, pyrogen-free distilled water.

3. The pharmaceutical composition of claim 1, wherein said interaction enhancer is ethylenediaminetetraacetic acid.

4. The pharmaceutical composition of claim 1, wherein said oil-in-water nanoemulsion has a mean particle size of 0.2-0.8 microns.

5. The pharmaceutical composition of claim 1, wherein said oil-in-water nanoemulsion has a mean particle size less than 0.5 microns.

6. The pharmaceutical composition of claim 1, wherein said oil-in-water nanoemulsion kills or disables Gram negative bacteria, Gram positive bacteria, viruses, spores, and fungi when in contact with said Gram negative bacteria, Gram positive bacteria, viruses, spores, and fungi.