Highly porous self-cohered web materials

• US 7,655,584 B2
• Filed: 07/29/2005
• Issued: 02/02/2010
• Est. Priority Date: 07/29/2005
• Status: Active Grant

• Current Assignee: W. L. Gore & Associates (W.L. Gore & Associates)
• Original Assignee: Gore Enterprise Holdings Incorporated
• Inventors: Biran, Roy, Cully, Edward H., White, Charles F., Flynn, Charles, Farnsworth, Ted R.
• Primary Examiner(s): Chriss; Jennifer A
• Application Number:
  US11/193,111
• Publication Number:
  US 20070027553A1
• Time in Patent Office: 1,649 Days
• Field of Search: None
• US Class Current: 442/401
• CPC Class Codes: A61B 17/07292 Reinforcements for staple line, e.g. pledgets
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: Y10T 442/608 Including strand or fiber material which is of specific structural definition
• CPC Class Codes: Y10T 442/674 Nonwoven fabric with a preformed polymeric film or sheet
• CPC Class Codes: Y10T 442/677 Fluorinated olefin polymer or copolymer sheet or film [e.g., TeflonR, etc.]
• CPC Class Codes: Y10T 442/681 Spun-bonded nonwoven fabric
• CPC Class Codes: Y10T 442/682 Needled nonwoven fabric
• CPC Class Codes: Y10T 442/688 Containing polymeric strand or fiber material

Abstract

The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a very high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. In some embodiments, the web materials exhibit significant thrombogenic properties.

Claims

1. An implantable thrombogenic article comprising melt-formed abraded filaments and continuous melt-formed filaments to form a porous web material, wherein said material is formed by self-cohering filaments to each other at multiple contact points and then subjecting the material to a carding procedure where at least some of the filaments are engaged and separated from each other, wherein said filaments comprise at least one semi-crystalline polymeric component covalently bonded to or blended with at least one amorphous polymeric component, wherein the filaments possess partial to full polymeric component phase immiscibility when in a crystalline state, wherein said implantable article has a percent porosity greater than ninety absent inclusion of any fillers or other added components that may effectively reduce said porosity, and a relative blood clot time value of approximately 0.7 when compared to the positive citrated calcium control value of 1.0.

2. The implantable article of claim 1 wherein the percent porosity is greater than ninety-one absent inclusion of any fillers or other added components that may effectively reduce said porosity.

3. The implantable article of claim 1wherein the at least one semi-crystalline polymeric component is covalently bonded to at least one amorphous polymeric component.

4. The implantable article of claim 3 wherein the components comprise a block copolymer.

5. The implantable article of claim 1 wherein the at least one semi-crystalline polymeric component is blended with the at least one amorphous polymeric component.

6. The implantable article of claim 5 wherein at least one of the components is a block co-polymer.

7. The implantable article of claim 1 wherein at least one semi-crystalline polymeric component has a melting point greater than eighty degrees centigrade (80°

C.).

8. The implantable article of claim 1 further comprising a delivery catheter housing said porous web material.

9. The implantable article of claim 8 further comprising a radio-opaque marker attached to said porous web material.

10. An implantable thrombogenic article comprising melt-formed abraded filaments and continuous melt-formed filaments to form a porous web material, wherein said material is formed by self-cohering filaments to each other at multiple contact points and then subjecting the material to a carding procedure where at least some of the filaments are engaged and separated from each other, wherein said filaments comprise a first semi-crystalline polymeric component covalently bonded to or blended with at least one additional semi-crystalline polymeric component, wherein the filaments possess partial to full polymeric component phase immiscibility when in a crystalline state, wherein said implantable article has a percent porosity greater than ninety absent inclusion of any fillers or other added components that may effectively reduce said porosity, and a relative blood clot time value of approximately 0.7 when compared to the positive citrated calcium control value of 1.0.

11. The implantable article of claim 10 wherein the percent porosity is greater than ninety-one absent inclusion of any fillers or other added components that may effectively reduce said porosity.

12. The implantable article of claim 10 wherein the at least one semi-crystalline polymeric component is covalently bonded to at least one amorphous polymeric component.

13. The implantable article of claim 12 wherein the components comprise a block copolymer.

14. The implantable article of claim 10 wherein the at least one semi-crystalline polymeric component is blended with the at least one amorphous polymeric component.

15. The implantable article of claim 14 wherein at least one of the components is a block co-polymer.

16. The implantable article of claim 10 wherein at least one semi-crystalline polymeric component has a melting point greater than eighty degrees centigrade (80°

C.).

17. The implantable article of claim 10 further comprising a delivery catheter housing said porous web material.

18. The implantable article of claim 17 further comprising a radio-opaque marker attached to said porous web material.