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Compositions and methods for the prevention and control of insulin-induced hypoglycemia

  • US 7,655,618 B2
  • Filed: 06/28/2005
  • Issued: 02/02/2010
  • Est. Priority Date: 12/27/2002
  • Status: Expired due to Fees
First Claim
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1. A method of treating diabetes in a human while reducing the risk of inducing hypoglycemia, said method comprising:

  • administering insulin in an amount therapeutically effective for the control of diabetes, wherein said insulin is administered in an amount of 1-20 Units of insulin per hour; and

    subcutaneously administering glucagon in an amount therapeutically effective for reducing the risk of hypoglycemia while administering the glucagon in a fashion to avoid the induction of hyperglycemia, wherein the glucagon is administered while the human has a blood glucose level of at least 70 mg/dl, wherein the glucagon is subcutaneously administered in a dosage that provides 2 to 16 ng of glucagon per kilogram of patient weight each minute for said hour, thereby treating diabetes while reducing the risk of inducing hypoglycemia.

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