Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

• US 7,655,688 B2
• Filed: 12/19/2005
• Issued: 02/02/2010
• Est. Priority Date: 02/27/2001
• Status: Active Grant

• Current Assignee: Bristol-Myers Squibb Company
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Balog, James Aaron, Sun, Chongqing, Salvati, Mark E., Gottardis, Marco M., Attar, Ricardo M., Pickering, Dacia A., Martinez, Rogelio L.
• Primary Examiner(s): Wang; Shengjun
• Application Number:
  US11/311,731
• Publication Number:
  US 20060111424A1
• Time in Patent Office: 1,506 Days
• Field of Search: 514/408, 514/410, 514/411, 514/412, 514/425, 514/311, 514/312, 514/314, 514/470, 514/307
• US Class Current: 514/411
• CPC Class Codes: A61K 31/403 condensed with carbocyclic rings, e.g. carbazole
• CPC Class Codes: A61K 31/407 condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
• CPC Class Codes: A61K 31/675 having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 15/08 for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 5/28 Antiandrogens
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Claims

1. A method of modulating the function of a nuclear hormone receptor in a mammal for the treatment of cancer, wherein the cancer cells express estrogen receptor, or contain progesterone or androgen receptor, comprising administering to the mammal an effective nuclear receptor modulating amount of a compound of the following formula (I) or a pharmaceutical acceptable salt thereof:

2. The method of claim 1, wherein:

R¹ and R^1′

are each independently selected from H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, heterocyclo or substituted heterocyclo, and aryl or substituted aryl;

R⁴ is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkylalkyl or substituted cycloalkylalkyl, arylalkyl or substituted arylalkyl, —

C(═

O)R¹, —

C(═

O)OR¹, —

C(═

O)NHR¹, —

SO₂R¹ or —

SO₂NR¹R^1′

;

R⁵ is alkyl or substituted alkyl, —

C(═

O)R¹, —

SO₂R¹, or —

SO₂NR¹R^1′

;

R⁷ and R^7′

are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, heterocycloalkyl or substituted heterocycloalkyl, halo, cyano, OR⁴, —

NHR⁴, —

NR⁵R⁵, —

C(═

O)R¹, —

OC(═

O)R¹, —

C(═

O)OR¹, —

C(═

O)NR¹R^1′

, —

SO₂R¹, or —

SO₂NR¹R^1′

;

or

two R⁷ and R^7′

groups attached to the same carbon atom may be joined to form a spiro ring, or two R⁷ and R^7′

groups attached to two different carbon atoms may be joined to form a fused, optionally-substituted monocyclic heterocyclic or carbocyclic ring.

3. The method of claim 1 wherein,

G is a monocyclic or bicyclic aryl or heterocyclo and is optionally substituted at one or more positions;

A₁ is CH, C(alkyl), or C(substituted alkyl);

A₂ is CH, C(alkyl), or C(substituted alkyl);

R⁴ is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkylalkyl or substituted cycloalkylalkyl, arylalkyl or substituted arylalkyl, —

C(═

O)R¹, —

C(═

O)OR¹, —

C(═

O)NHR¹, —

SO₂R¹ or —

SO₂NR¹R^1′

;

R⁵ is alkyl or substituted alkyl, —

C(═

O)R¹, —

SO₂R¹, or —

SO₂NR¹R^1′

; and

R⁷ and R^7′

are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, heterocycloalkyl or substituted heterocycloalkyl, halo, cyano, OR⁴, —

NHR⁴, —

NR⁵R⁵, —

C(═

O)R¹, —

OC(═

O)R¹, —

C(═

O)OR¹, —

C(═

O)NR¹R^1′

, —

SO₂R¹, or —

SO₂NR¹R^1′

;

or

two R⁷R^7′

groups are joined to a spiro cyclopropyl, or said R⁷ and R^7′

groups may be joined to form a fused, optionally-substituted monocyclic heterocyclic or carbocyclic ring; and

R⁸ and R^8′

are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, heterocycloalkyl or substituted heterocycloalkyl, halo, cyano, OR⁴, —

NHR⁴, —

NR⁵R⁵, —

C(═

O)R¹, —

OC(═

O)R¹, —

C(═

O)OR¹, —

C(—

O)NR¹R^1′

, —

SO₂R¹, or —

SO₂NR¹R^1′

.

4. The method of claim 1, wherein said cancer is prostate cancer.

5. The method of claim 1 wherein,

G is a monocyclic or bicyclic aryl or heterocyclo and is optionally substituted at one or more positions;

A¹ is CH, C(alkyl), or C(substituted alkyl);

A² is CH, C(alkyl), or C(substituted alkyl);

R¹ and R^1′

are each independently selected from H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, heterocyclo or substituted heterocyclo, and aryl or substituted aryl;

R⁴ is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkylalkyl or substituted cycloalkylalkyl, arylalkyl or substituted arylalkyl, —

C(═

O)R¹, —

C(—

O)OR¹, —

C(═

O)NHR¹, —

SO₂R¹ or —

SO₂NR¹R^1′

;

R⁵ is alkyl or substituted alkyl, —

C(═

O)R¹, —

SO₂R¹, or —

SO₂NR¹R^1′

,

R⁷ and R^7′

are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, heterocycloalkyl or substituted heterocycloalkyl, halo, cyano, OR⁴, —

NHR⁴, —

NR⁵R⁵, —

C(═

O)R¹, —

OC(═

O)R¹, —

C(═

O)OR¹, C(═

O)NR¹R^1′

, —

SO₂R¹, or —

SO₂NR¹R^1′

;

or

two R⁷ and R^7′

groups are joined to a spiro cyclopropyl, or said R⁷ and R^7′

groups may be joined to form a fused, optionally-substituted monocyclic heterocyclic or carbocyclic ring; and

R⁸ and R^8′

are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, heterocycloalkyl or substituted heterocycloalkyl, halo, cyano, OR⁴, —

NHR⁴, —

NR⁵R⁵, —

C(═

O)R¹, —

OC(═

O)R¹, —

C(═

O)OR¹, —

C(═

O)NR¹R^1′

, —

SO₂R¹, or —

SO₂NR¹R^1′

.

6. The method of claim 5, wherein G is phenyl or napthyl optionally substituted at one to three positions.

7. The method of claim 1 wherein,

G is phenyl or napthyl optionally substituted at one to three positions;

A₁ is CH, C(alkyl), or C(substituted alkyl;

A₂ is CH, C(alkyl), or C(substituted alkyl);

R¹ and R^1′

are each independently selected from H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, heterocyclo or substituted heterocyclo, and aryl or substituted aryl;

R⁴ is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkylalkyl or substituted cycloalkylalkyl, arylalkyl or substituted arylalkyl, C(═

O)R¹, —

C(—

O)OR¹, —

C(═

O)NHR¹, —

SO₂R¹ or —

SO₂NR¹R^1′

;

R⁵ is alkyl or substituted alkyl, —

C(—

O)R¹, —

SO₂R¹, or —

SO₂NR¹R^1′

;

R⁷ and R^7′

are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, heterocycloalkyl or substituted heterocycloalkyl, halo, cyano, OR⁴, —

NHR⁴, —

NR⁵R⁵, —

C(—

O)R¹, —

OC(═

O)R¹, —

C(═

O)OR¹, —

C(═

O)NR¹R^1′

, —

SO₂R¹, or —

SO₂NR¹R^1′

;

or

two R⁷ and R^7′

groups are joined to a spiro cyclopropyl, or said R⁷ and R^7′

groups may be joined to form a fused, optionally-substituted monocyclic heterocyclic or carbocyclic ring; and

R⁸ and R^8′

are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, heterocycloalkyl or substituted heterocycloalkyl, halo, cyano, OR⁴, —

NHR⁴, —

NR⁵R⁵, —

C(═

O)R¹, —

OC(═

O)R¹, —

C(═

O)OR¹, —

C(═

O)NR¹R^1′

, —

SO₂R¹, or —

SO₂NR¹R¹.

8. A method of modulating the function of a nuclear hormone receptor in a mammal for the treatment of cancer, wherein the cancer cells express estrogen receptor, or contain progesterone or androgen receptor, comprising administering to the mammal an effective nuclear receptor modulating amount of a compound selected from:

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-hydroxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[1H-tetrazol-5-yl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1;

1),

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-2-oxo-6-benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-3-methyl-2-oxo-6-benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methanol-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1-methyl-2-oxo-1H-indol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2-Fluorenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(1H-Benzotriazol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[3-Chloro-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1H-inden-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Chloro-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(7-hydroxy-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indol-5-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2,4,1,3-Benzodioxol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-Amino-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-4-quinolinyl)-4,7-methano-1H isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(8-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-isoquinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,5-Dimethoxy-4-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1,1-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2,3,5,6-Tetrafluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzonitrile,

(3aα

,4α

,7′

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,4-Difluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-1H-indol-6-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,4-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trichlorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1,1-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1,1-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1,11-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-4-Bromo-[4-trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-4-Fluoro-3-(trifluoromethyl)phenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-Chloro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Chloro-C-methoxy-5-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,5-Dichloro-4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-3-nitrophenyl)-4,7-methano-1,1-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Amino-3-nitrophenyl-3a,4,7,7a-tetrahydro-4,7-methano-1,1-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2,2′

-(2,3,5,6-Tetramethyl-1,4-phenylene)bis[3a,4,7,7a-tetrahydro-4,7-methano-1,4-isoindole-1,3(2H)-dione],

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trimethoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-hydroxy-4-methoxyphenyl)-4,7-methano-1,1-isoindole-1,3(2H)-dione,

(3aα

,4a,7α

, 7aα

)-2-(5-Chloro-2-hydroxy-4-nitrophenyl-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,(3aα

,4α

,7α

, 4aα

)-3a,4,7,7a-Tetrahydro-2-(2-methoxy-3-dibenzofuranyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3,4-trifluorophenyl)-4,7-Methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-2-methyl-1,3-dioxo-1H-isoindol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[3-[(Diethylamino)methyl]-4-hydroxyphenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(6-Benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methoxybenzenecarboxylic acid,

methyl ester,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-oxo-2H)-benzopyran-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-8-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3,5,6-tetramethyl-4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3α

, 4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trimethylphenyl)-4,7-Tetrahydro-1H-isoindole-1,3(2H)-dione,

(3α

, 4α

,7α

,7aα

)-2-(4-Fluoro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methoxy-4-methylphenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2′

-hydroxy[1,1′

;

3′

,1″

-terphenyl]-5′

-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

7α

, 7aα

)-3a,4,7,7a-Tetrahydro-2-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4Amino-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-N-2-Chloro-6-fluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)phenyl)acetamide,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[3-trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[2-Ethoxy-8-methyl-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3α

, 4α

,7α

,7aα

)-2-[1,2-Dihydro-8-methyl-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(9-Ethyl-9H-carbazol-2-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-1,4-(1-piperidinyl)phenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(4-morpholinyl)phenyl]A,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(7-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(3-Chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1,2,3,4-tetrahydro-2-oxo-7-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(4-methyl-1-piperazinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-(Diethylamino)-1-naphthalenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(8-hydroxy-5-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2,4,4-Fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(1,2,3-thiadiazol-4-yl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-N-[5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-3-(trifluoromethyl)phenyl]acetamide,

(3aα

,4α

,7α

,7aα

)-2-[3-Amino-5-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-[1,2-Dihydro-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-1-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-{5-Ethoxy-2-(methoxymethyl)-4-(4-morpholinyl)phenyl}-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[(1R)-1-(1-naphthalenyl)ethyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[(1S)-1-(1-naphthalenyl)ethyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[7-(trifluoromethyl)-4-quinolinyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[8-(trifluoromethyl)-4-quinolinyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethyl-5-isoxazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-tetrahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-nitro-8-isoquinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

trifluoroacetate (1;

1),

(3α

,4α

,7α

,7aα

)-2-(4-Amino-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methylphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(4-Bromophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(5-Bromo-8-isoquinolinyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(7,8-Dichloro-5-quinolinyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methyl-4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-N-[4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenyl]-N′

-methylurea,

(3aα

,4α

,7α

,7aα

)-2-(6-Bromo-1,2-benzisoxazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(5-Bromo-1,2-benzisoxazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-1H-1-indazole-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(6-Chloro-1H-indazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-nitro-1,2-benzisoxazol-3-yl)-4,7-methano-1H-isoindole-1,3(21-1)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(3-Benzofuranyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(4-Chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2-Fluorenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(1H-Benzotriazol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

))-2-[3-Chloro-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(2,3-Dihydro-1H-inden-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1,1-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(4-Chloro-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(5-Amino-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(7-hydroxy-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indol-5-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(1,3-Benzodioxol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-Amino-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-iodophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(8-quinolinyl)-4,7-ethano-1H-isoindole-1,3(211)-dione,

(3aα

,4α

,7α

,7aα

)-2-(1,4-Benzodioxin-6-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-benzopyran-7-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-isoquinolinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(2,5-Dimethoxy-4-iodophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2-Amino-4,5-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(3,4-Difluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-(3-Chloro-4-fluorophenyl-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,4-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3α

,4α

,7α

,7aα

)-2-(3-Chloro-4-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-methylphenyl-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(4-Fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Chloro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-[4-Chloro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Chloro-2-methoxy-5-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,5-Dichloro-4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(4-Amino-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Amino-2,3,5,6-tetramethylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trimethoxyphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,4-Dimethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-hydroxy-4-methoxyphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-5-nitro-2-pyridinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methoxy-3-dibenzofuranyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3,4-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2,3-Dihydro-2-methyl-1,3-dioxo-1H-isoindol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-[3-[(Diethylamino)methyl]-4-hydroxyphenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(6-Benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-methyl-8-quinolinyl-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,3,5,6-tetramethyl-4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trimethylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(4-Fluoro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(3-methoxy-4-methylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,8α

,8aα

)-2-(2,3-Dimethyl-1H-indol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2′

-hydroxy[1,1′

;

3′

,1′

-terphenyl]-5-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5,6,7,8-tetrahydro-3-hydroxy-2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)hexahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-hydroxy-4,5-dimethylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2,2,3,3-tetrafluoro-2H-dihydro-1,4-benzodioxin-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-5-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Amino-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(5-hydroxy-1-naphthenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

-4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,8α

,8aα

)-2-(9-Ethyl-9H-carbazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,8α

,8aα

)-2-[1,2-Dihydro-8-methyl-2-oxo-4-(trifluoromethyl-7-quinolinyl]-3a,4,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,4-Dichlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-3-methylphenyl)-4,4-a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4-a,5,5a,6,6a-Hexahydro-2-(1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4-a,5,5a,6,6a-Hexahydro-2-(2-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dichlorophenyl)-4,4-a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4-a,5,5a,6,6a-Hexahydro-2-1,4-nitro-3,4-trifluoromethyl)phenyl-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[3,5-Bis(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5α

,6β

,6aα

)-4,4-a,5,5a,6,6a-Hexahydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2,3-Dihydro-1H-inden-5-yl-4,4-a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-1-naphthalenecarbonitrile,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-1-naphthalenyl)-4,4a,5,5a/5,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4-2-(4-Chloro-1-naphthalenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(5-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(6-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4-a,5,5a,6,6a-Hexahydro-2-(5-isoquinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dinitrophenyl)-4,4-a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2,4,5-trifluorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[2-Fluoro-5-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2-Fluoro-5-methyl-phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2-Chloro-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,3,4aα

,5aα

,6β

,6aα

)-2-[2-Chloro-5-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Fluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,4-Difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Fluoro-4-methylphenyl)-4,4-a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chloro-4-fluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3,4,5-trichlorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2(3-Chloro-4-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-iodophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Acetylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2,4,3,4-Dimethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dimethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(hydroxymethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(Ethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-3-(trifluoromethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Fluoro-3-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Fluoro-3-(trifluoromethyl)phenyl-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

, 5aα

,6β

,6aα

)-2-(4-Chloro-3-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-iodophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-(1-methylethyl)phenyl-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-methyl-3-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Ethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-propylphenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2,3,4-trifluorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[4-(1,1-Dimethylethyl)-3-nitrophenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

-4-2-(4-Bromo-2,6-difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

-2-(6-Benzothiazolyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-1-Hexahydro-2-(2-methyl-8-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

, 4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Fluoro-3-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(1,3-Dihydro-3-oxo-5-isobenzofuranyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(5-Acetyl-2-methyl-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2-Ethyl-5-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-5-benzofuranyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(2,3-Dihydro-1-oxo-1H-inden-5-yl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(1H-indazol-5-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Bromo-3-chlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethoxy)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-methoxy-3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dibromophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-iodo-4-methylphenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

-2-(3-Chloro-4-iodophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-6-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(4-Chloro-3-methylphenyl-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a, 5,5a, 6,6a-Hexahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3α

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[2-[(1-methylethyl)amino]-5-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Chloro-4-fluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(3-methyl-4-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2,4,5-[(Difluoromethyl)sulfonyl)-2-methoxyphenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(1-methylethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-L(trifluoromethyl)thio)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5α

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[2-(2-methoxyphenoxy)-5-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4α

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3-Acetyl-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-[3-(1H-Dimethylethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[2-methyl-3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-2-(2-Amino-4,5-dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(8-hydroxy-5-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3 (2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-1-naphthalenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(2-Fluorenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(2-methyl-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Chloro-4-fluorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(1-oxido-4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(6-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(1-oxido-6-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(5-nitro-8-isoquinolinyl)-4,7-methano-1,11-isoindole-1,3(2H)-dione, trifluoroacetate (1;

1),

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(methylsulfanyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(methylthio)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(methylsulfinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Fluoro-1-naphthalenyl)hexahydro-4,3-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(1,1-Dioxido-2H-naphth[1,8-cd]isothiazol-5-yl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-(6-hydroxy-3-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(1,2-Benzisothiazol-3-yl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3-Benzofuranyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-Hexahydro-2-[4-(4-isothiazolyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione (3aα

,4α

,4α

,5α

,6α

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4α

,4α

,5α

,6α

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4α

,4aβ

,5aβ

,6α

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4α

,4aβ

,5aβ

,6α

,6aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4-a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(3,5-Dichlorphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-4,4a,5,5a,6,6a-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,4aα

,5aα

,6β

,6aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione,

(3aα

,4β

,7β

,7aα

)-3a,4,7,7a-tetrahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

, 7β

,7aα

)-Hexahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-[3-trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-Hexahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-2-(3,5-Dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-(2-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 5α

,7α

,7aα

)-Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(1H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-(1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-2-(3,4-Dichlorophenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1;

1),

(3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-[4,4-nitro-3-(trifluoromethyl)phenyl]-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,5α

,7α

,7aα

)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-[4-(methylthio)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(5-chloro-2-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7α

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(3-methoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(2,3-dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(3,4-dichlorophenyl-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromophenyl-4,5,6,7,8,8-hexachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-[2-methyl-5-(1-methylethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(3-chloro-4-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(2,3-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-[3-(methylthio)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-4,5,6,7,8,8-Hexachloro-2-(4-fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-(6-methyl-2-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-(4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(4-Ethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-(3-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-(2-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-(3-methyl-2-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[4-(2-hydroxyethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-(2-mercaptophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-(2-hydroxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[4-phenyl-methoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[2-(phenylmethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[3-(phenylmethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[4[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[2-[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[3,4[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[4-[(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[3-[(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[2-[(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[4-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[2-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[3-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[4-[(2-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[4-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[2-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[2-[(2-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[3-[(2-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[3-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[(Benzoyloxy)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-[3-(3,4-Dimethylbenzoyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(5-Chloro-2-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(2-Acetylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-2-[4-(5-oxazolyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-5-methyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2′

-[4-Bromo-3-(trifluoromethyl)phenyl]-3′

a,4′

,7′

,7′

a-tetrahydrospiro[cyclopropane-1,8-[4,7]methano[1H]isoindole]-1′

,3′

(2′

H)-dione,

(3aα

,4β

,7β

,7aα

)-2-[3,5-Bis(trifluoromethyl)phenyl]hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-Hexahydro-8-(1-methylethylidene)-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-2-(4-Bromo-1-naphthalenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-Hexahydro-8,8-dihydroxy-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7β

,7aα

)-2-[3,5-Bis(trifluoromethyl)phenyl]hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4β

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(4-Bromo-3-methylphenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 7α

,7aα

)-Tetrahydro-2-[[3-(trifluoromethyl)phenyl]amino]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-2-[(3-Chlorophenyl)amino]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

, 5α

,7α

,7aα

)-Hexahydro-5-mercapto-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3aα

,4α

,7α

,7aα

)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

(3a′

α

,4′

α

,7′

α

,7a′

α

)2′

(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-3a′

,4′

,7′

, 7a′

-tetrahydrospiro[cyclopropane-1,8′

-[4,7]methano[1H]isoindole]1′

,3′

(2′

H)-dione,

(3aα

,4α

, 5α

,7α

,7aα

)-Hexahydro-5-(4-nitrophenyl)-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

Hexahydro-2-(2-mercaptophenyl)-4,7-methano-[1H]-isoindole-1,3(2H)-dione,

4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, ethyl ester,

2-[4-(Diethylamino)phenyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

5-(Acetyloxy)hexahydro-2-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

5-(Acetyloxy)-2-(4-chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

5-(Acetyloxy)hexahydro-2-(2-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

5-(Acetyloxy)-2-(3-chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

Hexahydro-5-hydroxy-2-(4-methoxyphenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(4-Ethoxyphenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione,

Hexahydro-5-hydroxy-2-(4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(4-Chlorophenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(2,4-Dichlorophenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione,

Hexahydro-5-hydroxy-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

5-(Acetyloxy)hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

5,6-Dibromo-2-(4-ethoxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(3-Chloro-2-methylphenyl)-3a,4,7,7a-tetrahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione,

3′

a,4′

,7′

,7′

a-Tetrahydro-2′

-(2,4,6-trimethylphenyl)spira[cyclopropane-1,8′

-[4,7]methano[1H]isoindole]-1′

,3′

(2′

H)-dione,

3a,4,7,7a-Tetrahydro-5-methyl-2-[4-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3a,4,7,7a-Tetrahydro-5-methyl-2-[4-(trifluoromethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione,

3′

a,4′

,7′

7′

a-Tetrahydro-2′

-(4-nitrophenyl)spiro[cyclopropane-1,8′

-[4,7]methano[1H]isoindole]-1′

,3′

(2′

H)-dione,

Hexahydro-2-(4-hydroxyphenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

2-(4-Ethoxyphenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione,

Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione and (3aα

,4α

,7α

,7aα

)-2-[4-nitro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,

or a pharmaceutically acceptable salt thereof.