Modified Fc molecules
First Claim
Patent Images
1. A composition of matter of the formula
(X1)a—
- F1—
(X2)b and multimers thereof, wherein;
F1 is an IgG1 Fc domain comprising SEQ ID NO;
603 modified so that it comprises at least one X3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS;
621, 622, 624, 625, 627, 628, 630, 632, 634, and 636 within a loop region of the IgG1 Fc domain, said loop region being in a non-terminal domain of the Fc domain;
X1 and X2 are each independently selected from -(L1)c-P1, -(L1)c-P1-(L2)d-P2, -(L1)c-P1-(L2)d-P2-(L3)e-P3, and -(L1)c-P1-(L1)d-P2-(L3)e-P3-(L4)f-P4;
X3 is independently selected from -(L5)c-P5, -(L5)c-P5-(L6)d-P6, -(L5)c-P5-(L6)d-P6-(L7)e-P7, and -(L5)c-P5-(L6)d-P6-(L7)e-P7-(L8)f-P8;
P1, P2, P3, and P4 are each independently sequences of pharmacologically active polypeptides or pharmacologically active peptides;
P5, P6, P7, and P8 are each independently sequences of pharmacologically active peptides;
L1, L2, L3, L4, L5, L6, L7, and L8 are each independently linkers; and
a, b, c, d, e, and f are each independently 0 or 1.
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Abstract
The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.
117 Citations
18 Claims
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1. A composition of matter of the formula
(X1)a—- F1—
(X2)band multimers thereof, wherein; F1 is an IgG1 Fc domain comprising SEQ ID NO;
603 modified so that it comprises at least one X3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS;
621, 622, 624, 625, 627, 628, 630, 632, 634, and 636 within a loop region of the IgG1 Fc domain, said loop region being in a non-terminal domain of the Fc domain;X1 and X2 are each independently selected from -(L1)c-P1, -(L1)c-P1-(L2)d-P2, -(L1)c-P1-(L2)d-P2-(L3)e-P3, and -(L1)c-P1-(L1)d-P2-(L3)e-P3-(L4)f-P4; X3 is independently selected from -(L5)c-P5, -(L5)c-P5-(L6)d-P6, -(L5)c-P5-(L6)d-P6-(L7)e-P7, and -(L5)c-P5-(L6)d-P6-(L7)e-P7-(L8)f-P8; P1, P2, P3, and P4 are each independently sequences of pharmacologically active polypeptides or pharmacologically active peptides; P5, P6, P7, and P8 are each independently sequences of pharmacologically active peptides; L1, L2, L3, L4, L5, L6, L7, and L8 are each independently linkers; and a, b, c, d, e, and f are each independently 0 or 1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- F1—
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10. A modified antibody, comprising an Fc domain, F1, wherein:
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F1 is an IgG1 Fc domain comprising SEQ ID NO;
603 modified so that it comprises at least one X3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS;
621, 622, 624, 625, 627, 628, 630, 632, 634, and 636 within a loop region of the IgG1 Fc domain, said loop region being in a non-terminal domain of the Fc domain, wherein;X3 is independently selected from -(L5)c-P5, -(L5)c-P5-(L6)d-P6, -(L5)c-P5-(L6)d-P6-(L7)e-P7, and -(L5)c-P5-(L6)d-P6-(L7)e-P7-(L8)f-P8; P5, P6, P7, and P8 are each independently sequences of pharmacologically active peptides; L5, L6, L7, and L8 are each independently linkers; and c, d, e, and f are each independently 0 or 1. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification