Method for evaluating extracellular water concentration in tissue
First Claim
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1. A method for assessing an extracellular water metric in a subject, said method comprising:
- using at least one sensor;
emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest;
detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest;
emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site;
detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and
using a processor;
processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric, wherein the hydrostatic pressure of the tissue site of interest differs from the hydrostatic pressure of the reference tissue site.
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Abstract
The present disclosure provides systems, devices, and/or methods for assessing body fluid-related metrics and/or changes therein. The disclosure further provides systems, devices, and/or methods for correlating body fluid-related metrics in a particular tissue with the corresponding whole-body metric. The disclosure also provides, systems, devices, and/or methods for assessment of such metrics to facilitate diagnosis and/or therapeutic interventions related to maintaining and/or restoring body fluid balance.
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Citations
30 Claims
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1. A method for assessing an extracellular water metric in a subject, said method comprising:
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using at least one sensor; emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest; detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest; emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site; detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and using a processor; processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric, wherein the hydrostatic pressure of the tissue site of interest differs from the hydrostatic pressure of the reference tissue site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method, for assessing an extracellular water metric in a subject, the method comprising:
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using at least one sensor; emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest; detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest; emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site; detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and using a processor; processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric, wherein the detecting light of at least one wavelength reflected by the tissue site of interest comprises detecting light with a detector and wherein the detecting light of at least one wavelength reflected by the reference tissue site comprises detecting light with said detector.
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27. A method, for assessing an extracellular water metric in a subject, the method comprising:
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using at least one sensor; emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest; detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest; emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site; detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and using a processor; processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric, wherein the tissue site of interest and reference tissue site are located within different organs.
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28. A method, for assessing an extracellular water metric in a subject, the method comprising:
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using at least one sensor; emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest; detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest; emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site; detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and using a processor; processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric, wherein the tissue site of interest and reference tissue site are at substantially the same site under differing hydrostatic pressures, wherein the hydrostatic pressure of the tissue site of interest is altered to differ from the hydrostatic pressure of the reference tissue site.
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29. A method, for assessing an extracellular water metric in a subject, the method comprising:
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using at least one sensor; emitting light of at least one wavelength toward a tissue site of interest, wherein a portion of the emitted light is reflected by the tissue site of interest; detecting at least one wavelength of the light reflected by the tissue site of interest from a position about one millimeter to about five millimeters from the tissue site of interest; emitting light of at least one wavelength toward a reference tissue site, wherein a portion of the emitted light is reflected by the reference tissue site; detecting at least one wavelength of the light reflected by the reference tissue site from a position about one millimeter to about five millimeters from the reference tissue site; and using a processor; processing detected reflected light from the tissue site of interest and detected reflected light from the reference tissue site to compute the extracellular water metric; and further comprising; (a) excising from the subject the site of interest before the emitting; (b) excising from the subject the reference site before the emitting, or (c) excising from the subject both the site of interest and the reference site before the emitting.
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30. A system for assessing an extracellular fluid metric in a subject, said system comprising:
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a local fluid content probe configured to assess a local fluid content metric at a tissue site; a location information sensor configured to assess location information of the probe, the tissue site of interest, or the probe and the tissue site of interest; and a processor, wherein the processor is operably coupled to the local fluid content probe, operably coupled to the location information sensor, and configured to process a local fluid content metric and location information to produce an extracellular fluid metric.
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Specification