Apparatus and methods for delivery of transcranial magnetic stimulation
First Claim
Patent Images
1. A method of transcranial magnetic stimulation, comprising:
- defining a cerebral cortical region of interest for a subject;
determining a stimulator position and orientation disposed to deliver an induced electric field substantially perpendicular to said cerebral cortical region of interest in accordance with a cortical column cosine aiming principle such that the electric field is parallel to cortical columns of the cerebral cortical region of interest;
positioning said subject to immobilize said cerebral cortical region of interest;
directing said stimulator to said subject so that said stimulator is focused to said cerebral cortical region of interest, said directing based on said determined stimulator position and orientation; and
delivering said TMS to said subject, said delivering comprising generating an electric field substantially perpendicular to said cerebral cortical region of interest.
1 Assignment
0 Petitions
Accused Products
Abstract
Disclosed are apparatus and methods for delivery of transcranial magnetic stimulation. The apparatus includes a TMS coil which when energized generates an electric field substantially parallel to a long axis of the coil and substantially normal to a surface of the coil. Furthermore disclosed an apparatus for delivery of TMS in which a coil is adapted to a robotic member for computer-aided control and delivery. Further disclosed are methods of TMS planning and delivery in which subject images are utilized to plan, position and orient the TMS coil for precise delivery. Disclosed also are TMS coils having unique designs to better focus and direct magnetic stimulation.
48 Citations
21 Claims
-
1. A method of transcranial magnetic stimulation, comprising:
-
defining a cerebral cortical region of interest for a subject; determining a stimulator position and orientation disposed to deliver an induced electric field substantially perpendicular to said cerebral cortical region of interest in accordance with a cortical column cosine aiming principle such that the electric field is parallel to cortical columns of the cerebral cortical region of interest; positioning said subject to immobilize said cerebral cortical region of interest; directing said stimulator to said subject so that said stimulator is focused to said cerebral cortical region of interest, said directing based on said determined stimulator position and orientation; and delivering said TMS to said subject, said delivering comprising generating an electric field substantially perpendicular to said cerebral cortical region of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method of transcranial magnetic stimulation, comprising:
-
positioning a subject to receive the transcranial magnetic stimulation; moving a transcranial magnetic stimulator to a first treatment position, the first treatment position computed to obtain maximum biological efficacy at a first target point of the subject, the maximum biological efficacy at the first target point realized when an induced electric field is parallel to a direction of a cortical column and perpendicular to a cortical surface of the first target point; and delivering the transcranial magnetic stimulation. - View Dependent Claims (11, 12, 13, 14, 15)
-
-
16. A method comprising:
-
positioning a subject to receive transcranial magnetic stimulation; locating a transcranial magnetic stimulator at a first treatment position that is perpendicular to a cerebral cortical region of interest of the subject in accordance with a cortical column cosine aiming principle, including that a cortex region is preferentially or exclusively activated, and a maximum activation of the cortex region is by an electric field oriented parallel to a columnar orientation of the cortex region; and delivering the transcranial magnetic stimulation to the subject. - View Dependent Claims (17, 18, 19, 20, 21)
-
Specification