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Vascular graft sterilization and decellularization

  • US 7,658,706 B2
  • Filed: 12/05/2006
  • Issued: 02/09/2010
  • Est. Priority Date: 12/05/2005
  • Status: Active Grant
First Claim
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1. A process for making a vascular graft more suitable for implantation into a recipient, the process comprising:

  • (a) contacting a vascular graft with an oxidizing sterilant; and

    (b) contacting the vascular graft with a cleaning solution;

    wherein during either step (a) or (b) or both,a pressure gradient in the range of from about 100 mm Hg to about 400 mm Hg across a wall of said vascular graft is maintained by the flow of said cleaning solution or said oxidizing sterilant through said vascular graft;

    wherein the contacting steps are at a temperature less than about 45°

    C. and for a total contact time less than about 8 hours; and

    wherein the vascular graft comprises allograft or xenograft vascular tissue.

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