Measuring device and measuring method for detecting analytes
First Claim
1. A device for the detection and/or determination of the concentration of at least one analyte present in a liquid medium, consisting ofa) a strip-shaped carrier (20) having two longitudinal edges (24), to which carrier (20) a printed multiple electrode set consisting of at least one reference electrode (30) and at least one working electrode (40) is applied andb) ligands which are suitable for binding a biologically active specific binding molecule or the analyte,wherein the devicecomprises a rigid reaction and detection chamber (50) adapted for continuous flow of the medium along said strip-shaped carrier (20), said reaction and detection chamber being formed by an elongated support (52) applied to said longitudinal edges (24) of said carrier (20) having a cover (54) disposed on said support (52), and thata liquid absorption element (60) is disposed downstream of said reaction and detection chamber (50), andfurther wherein the elongated support (52) is divided in two and is permanently adhesively attached, in the form of two strips, to the two longitudinal edges (24) of said carrier (20) and said strips only lie on one part of said two longitudinal edges (24) of said carrier (20), there being an interstice (70) between said strips and said liquid absorption element (60) from which interstice (70) said strips extend upstream on said longitudinal edges (24).
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Accused Products
Abstract
A measuring device for the detection and determination of the concentration of at least one analyte in a liquid medium consists of a polymeric carrier having biologically active specific binding molecules dried on its upstream portion. A multiple electrode set consisting of at least one reference electrode and at least one working electrode is located thereon in a downstream region. The working electrode is provided with biologically active specific binding molecules. The carrier has a sample application zone, which is adjoined, in the downstream direction, by a non-deformable, through-flow reaction and detection chamber, a variably dimensioned interstice, and a liquid absorption element. For a qualitative and quantitative analyte determination, two liquid media are applied in succession to the sample application zone. While the first can contain the wanted analyte, the second provides for the formation of an electrical signal.
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Citations
41 Claims
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1. A device for the detection and/or determination of the concentration of at least one analyte present in a liquid medium, consisting of
a) a strip-shaped carrier (20) having two longitudinal edges (24), to which carrier (20) a printed multiple electrode set consisting of at least one reference electrode (30) and at least one working electrode (40) is applied and b) ligands which are suitable for binding a biologically active specific binding molecule or the analyte, wherein the device comprises a rigid reaction and detection chamber (50) adapted for continuous flow of the medium along said strip-shaped carrier (20), said reaction and detection chamber being formed by an elongated support (52) applied to said longitudinal edges (24) of said carrier (20) having a cover (54) disposed on said support (52), and that a liquid absorption element (60) is disposed downstream of said reaction and detection chamber (50), and further wherein the elongated support (52) is divided in two and is permanently adhesively attached, in the form of two strips, to the two longitudinal edges (24) of said carrier (20) and said strips only lie on one part of said two longitudinal edges (24) of said carrier (20), there being an interstice (70) between said strips and said liquid absorption element (60) from which interstice (70) said strips extend upstream on said longitudinal edges (24).
Specification