System for taking wide-field beam-eye-view (BEV) x-ray-images simultaneously to the proton therapy delivery

• US 7,659,521 B2
• Filed: 04/14/2005
• Issued: 02/09/2010
• Est. Priority Date: 03/09/2005
• Status: Active Grant

• Current Assignee: Paul Scherrer-Institut (Schweizerische Eidgenossenschaft)
• Original Assignee: Paul Scherrer-Institut (Schweizerische Eidgenossenschaft)
• Inventors: Pedroni, Eros
• Primary Examiner(s): Souw; Bernard E
• Application Number:
  US11/885,707
• Publication Number:
  US 20080191142A1
• Time in Patent Office: 1,762 Days
• Field of Search: 250/306, 250/309, 250/396.R, 250/398, 250/370.09, 250/491.1, 250/492.1, 250/492.3, 378/9, 378/65, 378/145, 600/411
• US Class Current: 250/396.00R
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1064 for adjusting radiation treatment in response to monitoring
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment

Abstract

A system for an intensity-modulated proton therapy of a predetermined target volume within an object includes a proton source to generate a proton beam, a number of proton beam forming units and a beam nozzle having an outlet for the proton beam to penetrate the predetermined target volume of the object, thereby defining a cross sectional scanning exit area. The system includes further a beam bending magnet disposed upstream of the nozzle, and an x-ray tube and an x-ray imager. The x-ray tube is associated with an irradiation channel within the beam bending magnet, wherein the irradiation channel is oriented along the prolongation of the nominal proton beam direction thereby delivering the x-ray beam along the proton beam direction.

Claims

1. A system for an intensity-modulated proton therapy of a predetermined target volume within an object, comprising:

a proton source in order to generate a proton beam;

a number of proton beam forming units;

a beam nozzle having an outlet for the proton beam to penetrate the predetermined target volume of the object, thereby defining a cross sectional scanning exit area;

a beam bending magnet being disposed upstream of the nozzle; and

an x-ray tube and an x-ray imager wherein the x-ray tube is associated with an irradiation channel within the beam bending magnet;

said irradiation channel being oriented along a prolongation of a nominal proton beam direction thereby delivering an x-ray beam along a proton beam direction.

2. The system according to claim 1, further comprising:

a couple of sweeper magnets being disposed upstream of said beam bending magnet in order to sweep the proton beam in both lateral directions before the proton beam enters into the beam bending magnet, wherein

said sweeper magnets and said beam bending magnet are controlled in order to guarantee a parallel beam orientation over the complete cross-sectional scanning exit area.

3. The system according to claim 1, wherein

the x-ray beam is delivered simultaneously to the proton beam.

4. The system according to claim 1, wherein

the imager is disposed downstream of the target volume within said object as seen downstream in direction of the proton beam.

5. The system according to claim 1, further comprising

first means for determining a position of the target volume relative to a beam orientation,

said first means comprising second means for determining a position of an anatomical landmark and/or an additional marker applied to the object whereby the position of the anatomical landmarks and/or the additional marker relative to the target volume is known by evaluating an image gained from the x-ray imager in treatment position;

said image being in addition optionally compared to 4d images

taken previously with a CT.

6. The system according to claim 5,

wherein said sweeper magnets and/or said beam bending magnet are controlled in order to compensate a movement of the target volume to be treated by applying compensation data to control means of the sweeper magnets and/or the beam bending magnets, said compensation data gained from the determination of the position of the target volume.

7. The system according to claim 5,

wherein said first means for determining the position of the target volume are means for tracking any lateral movement of the target volume.

8. The system according to claim 1, wherein

the proton beam is delivered in synchronization with one of an expected movement of the target object and an expected non-movement of the target object.

9. The system according to claim 8,

wherein the proton beam is delivered discontinuously according to a desired synchronization.

10. A method for delivering an intensity-modulated proton therapy to a predetermined target volume within an object, comprising the steps of:

providing a proton source in order to generate a proton beam;

providing a number of proton beam forming units in order to form the proton beam in a predetermined manner;

providing a beam nozzle having an outlet for the proton beam in order to penetrate the predetermined target volume of the object with the proton beam,

providing a beam bending magnet being disposed upstream of the nozzle; and

applying an x-ray beam along an irradiation channel within the beam bending magnet;

said irradiation channel being oriented along a prolongation of a nominal proton beam direction in order to deliver the x-ray beam along a proton beam direction to the target volume.

11. The method according to claim 10, further comprising the steps of:

providing a couple of sweeper magnets being disposed upstream of said beam bending magnet in order to sweep the proton beam in both lateral directions before the proton beam enters into the beam bending magnet, and

controlling said sweeper magnets and/or said beam bending magnet in order to guarantee a parallel beam orientation over a complete cross-sectional scanning area defined by the nozzle.

12. The method according to claim 10, further comprising

delivering the x-ray beam simultaneously to the proton beam.

13. The method according to claim 10, further comprising

disposing the imager downstream of the target volume within said object as seen downstream in direction of the proton beam.

14. The method according to claim 10, further comprising

determining a position of the target volume relative to the beam orientation by determining a position of an anatomical landmark and/or an additional marker applied to the object whereby the position of the anatomical landmarks and/or the additional marker relative to the target volume is known by evaluating an image gained from the x-ray imager.

15. The method according to claim 14, further comprising

controlling said sweeper magnets and/or said beam bending magnet in order to compensate a movement of the target volume to be treated by applying compensation data to control means of the sweeper magnets and/or the beam bending magnets, thereby gaining said compensation data from the determination of the position of the target volume.

16. The method according to claim 14, further comprising

using the determination of the position of the target volume for tracking any lateral movement of the target volume.

17. The method according to claim 10, further comprising

delivering the proton beam in synchronization with one of an expected movement of the target object, and an expected non-movement of the target object;

.

18. The system according to claim 17, further comprising

delivering the proton beam discontinuously according to the desired synchronization.