Iontophoresis device

• US 7,660,626 B2
• Filed: 08/02/2005
• Issued: 02/09/2010
• Est. Priority Date: 02/03/2005
• Status: Expired due to Fees

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Inventors: Tanioka, Akihiko, Kanamura, Kiyoshi, Minagawa, Mie, Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Stigell; Theodore J
• Application Number:
  US11/195,364
• Publication Number:
  US 20060173401A1
• Time in Patent Office: 1,652 Days
• Field of Search: 604 20- 21, 604/174, 604/180
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane

Abstract

The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.

Claims

1. An iontophoresis device, comprising an active electrode structure comprising:

an electrode to which a positive electrical potential is applied;

a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; and

a cellulose resin film selected from the group consisting of regenerated cellulose, cellulose ester, cellulose ether, and cellulose nitrate and placed on a front side of the drug holding part,

wherein the positively charged drug ions are administered through the cellulose resin film; and

wherein the cellulose resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.

2. An iontophoresis device, comprising an active electrode structure comprising:

an electrode to which a positive electrical potential is applied;

a drug holding part for holding a drug solution containing positively chanted drug ions, the drug holding part being placed on the front side of the electrode; and

a cellulose resin film selected from the group consisting of regenerated cellulose, cellulose ester, cellulose ether, and cellulose nitrate and placed on a front side of the drug holding part,

wherein the positively charged drug ions are administered through the cellulose resin film, and wherein;

the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and

the drug holding part is placed on a front side of the anion exchange membrane.

3. An iontophoresis device, comprising an active electrode structure comprising:

an electrode to which a positive electrical potential is applied;

a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; and

a cellulose resin film selected from the group consisting of regenerated cellulose, cellulose ester, cellulose ether, and cellulose nitrate and placed on a front side of the drug holding part, wherein the are administered through the cellulose resin film,

a counter electrode structure, comprising;

a second electrode to which a negative electrical potential is applied;

a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;

a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;

a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and

a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.

4. An iontophoresis device, comprising an active electrode structure comprising:

an electrode to which a positive electrical potential is applied;

a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; and

a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part,

wherein the drug ions are administered through the cellulose-based resin film.

5. The iontophoresis device according to claim 4, wherein the cation exchange membrane has a porous structure filled with an ion-exchange resin.

6. The iontophoresis device according to claim 4, wherein a cation exchange group is introduced to the cellulose-based resin film.

7. The iontophoresis device according to claim 4, wherein the cellulose-based resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.

8. The iontophoresis device according to claim 4, wherein:

the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and

the drug holding part is placed on a front side of the anion exchange membrane.

9. The iontophoresis device according to claim 4, further comprising a counter electrode structure, comprising:

a second electrode to which a negative electrical potential is applied;

a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;

a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;

a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and

a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.

10. The iontophoresis device according to claim 4, wherein an interface of the cation exchange membrane and the cellulose-based resin film are bonded, whereby the cation exchange membrane is integrated with the cellulose-based resin film.

11. The iontophoresis device according to claim 10, wherein the cation exchange membrane has a structure in which a pore of a porous film is filed with an ion-exchange resin.

12. The iontophoresis device according to claim 10, wherein a cation exchange group is introduced to the cellulose-based resin film.

13. The iontophoresis device according to claim 10, wherein:

the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on the a front side of the electrolyte solution holding part; and

the drug holding part is placed on a front side of the anion exchange membrane.

14. The iontophoresis device according to claims 10, further comprising a counter electrode structure, comprising:

a second electrode to which a negative electrical potential is applied;

a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;

a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;

a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and

a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.

15. The iontophoresis device according to claim 10, wherein:

a surface of the cation exchange membrane facing the cellulose-based resin film is roughened; and

the interface are bonded by any one of adhesion with an adhesive, a cross-linking reaction with a cross-linker, and formation of the cellulose-based resin film on the cation exchange membrane.

16. The iontophoresis device according to claim 15, wherein the cation exchange membrane has a porous structure filled with an ion-exchange resin.

17. The iontophoresis device according to claim 15, wherein a cation exchange group is introduced to the cellulose-based resin film.

18. The iontophoresis device according to claim 15, wherein the cellulose-based resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.

19. The iontophoresis device according to claim 15, wherein:

the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and

the drug holding part is placed on a front side of the anion exchange membrane.

20. The iontophoresis device according to claim 15, further comprising a counter electrode structure, comprising:

a second electrode to which a negative electrical potential is applied;

a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;

a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;

a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and

a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.

21. The iontophoresis device according to claim 4, wherein a cation exchange group is introduced to the cellulose-based resin film.

22. The iontophoresis device according to claim 21, wherein the cellulose-based resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.

23. The iontophoresis device according to claim 21, wherein:

the active electrode structure further comprises an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and

the drug holding part is placed on a front side of the anion exchange membrane.

24. The iontophoresis device according to claim 21, further comprising:

a counter electrode structure comprising;

a second electrode to which a negative electrical potential is applied;

a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;

a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;

a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and

a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.