Method and apparatus for hypoglossal nerve stimulation

• US 7,660,632 B2
• Filed: 06/28/2007
• Issued: 02/09/2010
• Est. Priority Date: 06/30/2006
• Status: Active Grant

• Current Assignee: Philips RS North America LLC (Koninklijke Philips N.V.)
• Original Assignee: RIC INVESTMENTS LLC (Koninklijke Philips N.V.)
• Inventors: Kirby, Todd, Witt, Erik K.
• Primary Examiner(s): Sykes; Angela D
• Assistant Examiner(s): STOKLOSA, JOSEPH A
• Application Number:
  US11/770,202
• Publication Number:
  US 20080161877A1
• Time in Patent Office: 957 Days
• Field of Search: 607116-118, 607/42
• US Class Current: 607/42
• CPC Class Codes: A61N 1/0526 Head electrodes A61N1/0551 takes precedence
• CPC Class Codes: A61N 1/0548 Oral electrodes
• CPC Class Codes: A61N 1/3601 of respiratory organs

Abstract

A method of treating sleep disordered breathing in a patient includes the steps of monitoring the patient for a pre-inspiratory drive signal indicative of the breathing cycle by sensing electroneurogram activity of a hypoglossal nerve of the patient; and electrically stimulating the hypoglossal nerve of the patient following each detection of the pre-inspiratory drive signal. An implantable apparatus for stimulating a hypoglossal nerve of a patient for the treatment of sleep disordered breathing includes an electrode positioned at least partially around the hypoglossal nerve with a monitoring contact and a stimulation contact and a controller operatively coupled to the monitoring contact and the stimulation contact. The monitoring contact monitors the electroneurogram activity of the hypoglossal nerve for a pre-inspiratory drive signal indicative of the onset of inspiration and sends a signal to the controller which in turn causes the stimulating electrode to electrically stimulate the hypoglossal nerve.

Claims

1. A method of treating sleep disordered breathing in a patient, comprising:

monitoring the patient for a pre-inspiratory drive signal indicative of the breathing cycle by sensing electroneurogram activity of a hypoglossal nerve of the patient; and

electrically stimulating the hypoglossal nerve of the patient following each detection of the pre-inspiratory drive signal.

2. The method of claim 1, wherein the hypoglossal nerve is electrically stimulated after a preset period of time elapses from detection of the pre-inspiratory drive signal.

3. The method of claim 1, wherein the hypoglossal nerve is monitored continuously for the pre-inspiratory drive signal.

4. The method of claim 1 further comprising:

amplifying the sensed electroneurogram activity of the hypoglossal nerve to obtain an amplified electroneurogram signal; and

using the amplified electroneurogram signal to trigger the direct electrical stimulation of said hypoglossal nerve.

5. The method of claim 1, further comprising:

sensing a body position of the patient; and

initiating monitoring of the patient when the patient is determined to be in a lying down position.

6. The method of claim 5, wherein the lying down position comprises a supine, prone, or side-lying position.

7. The method of claim 1, further comprising connecting a stimulating nerve electrode to the hypoglossal nerve so that the nerve electrode at least partially encircles the hypoglossal nerve.

8. The method of claim 7, wherein the stimulating nerve electrode comprises at least first and second contacts and the step of electrically stimulating the hypoglossal nerve comprises passing electrical stimulation pulses between first and second contacts of the nerve electrode and through tissue of the hypoglossal nerve.

9. The method of claim 7, wherein the electroneurogram activity of the hypoglossal nerve is sensed with a third contact of the nerve electrode.

20. The method of claim 1, wherein the pre-inspiratory drive signal comprises a signal generated by the central nervous system and propagated to the hypoglossal nerve prior to the onset of inspiration.

10. A method of stimulating a hypoglossal nerve of a patient for the treatment of sleep disordered breathing, comprising:

continuously monitoring the hypoglossal nerve of the patient;

detecting a pre-inspiratory drive signal from the hypoglossal nerve indicative of the breathing cycle, the pre-inspiratory drive signal being generated by the central nervous system and propagated to the hypoglossal nerve prior to the onset of inspiration; and

electrically stimulating the hypoglossal nerve in response to the detected pre-inspiratory drive signal to prevent occlusion of the patient'"'"'s upper airway.

11. The method of claim 10, wherein the hypoglossal nerve is electrically stimulated after a preset period of time elapses from detection of the pre-inspiratory drive signal.

12. The method of claim 10, further comprising:

amplifying the detected pre-inspiratory drive signal; and

electrically stimulating the hypoglossal nerve in response to the amplified pre-inspiratory drive signal.

13. The method of claim 12, wherein the pre-inspiratory drive signal is amplified by increasing the frequency, amplitude, or a combination thereof of the detected pre-inspiratory drive signal.

14. The method of claim 12, wherein the amplified pre-inspiratory drive signal triggers the electrical stimulation of said hypoglossal nerve.

15. The method of claim 12, further comprising:

sensing a body position of the patient; and

continuously monitoring of the patient only when the patient is determined to be in a lying down position.

16. The method of claim 15, wherein the lying down position comprises a supine, prone, or side-lying position.

17. The method of claim 10, further comprising connecting a stimulating nerve electrode (5) to the hypoglossal nerve so that the nerve electrode at least partially encircles the hypoglossal nerve.

18. The method of claim 17, wherein the stimulating nerve electrode comprises at least first and second contacts and the step of electrically stimulating the hypoglossal nerve comprises passing electrical stimulation pulses between first and second contacts of the nerve electrode and through tissue of the hypoglossal nerve.

19. The method of claim 18, wherein the monitoring the hypoglossal nerve (3) of the patient comprises monitoring the electroneurogram activity of the hypoglossal nerve with a third contact of the nerve electrode.

21. A method of treating sleep disordered breathing in a patient, comprising:

detecting a pre-inspiratory drive signal by sensing electroneurogram activity of a hypoglossal nerve of the patient, the pre-inspiratory drive signal comprising a signal generated by the central nervous system and propagated to the hypoglossal nerve prior to the onset of inspiration; and

electrically stimulating the hypoglossal nerve of the patient in response to the detection of the pre-inspiratory drive signal.