Radiotherapy treatment monitoring using ultrasound
First Claim
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1. A method of assessing cell condition in response to treatment, the method comprising the steps of:
- a. obtaining a baseline ultrasound scan of a treatment area of a patient;
b. obtaining, subsequent to the baseline scan, one or more temporally distinct treatment ultrasound scans of the treatment area at various times during a course of treatment sessions;
c. comparing at least one of the one or more treatment ultrasound scans to the baseline ultrasound scan;
d. based on the comparison, constructing one or more damage maps representing cell damage within the treatment area thereby providing a predictive model of tissue damage due to the treatment;
e. selecting a hypothetical radiation dosage and delivery pattern; and
f. using the predictive model, generating a map of expected tissue damage resulting from the hypothetical radiation dosage and delivery pattern.
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Abstract
Methods and systems for assessing the effects of therapy on a patient include obtaining baseline and treatment ultrasound scans of a treatment area of a patient where the treatment ultrasound scans are taken subsequent to the baseline scan and at various times during a course of radiotherapy treatment sessions. The baseline and treatment ultrasounds are compared, and as a result a damage map representing cell death within the treatment area can be constructed.
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Citations
25 Claims
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1. A method of assessing cell condition in response to treatment, the method comprising the steps of:
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a. obtaining a baseline ultrasound scan of a treatment area of a patient; b. obtaining, subsequent to the baseline scan, one or more temporally distinct treatment ultrasound scans of the treatment area at various times during a course of treatment sessions; c. comparing at least one of the one or more treatment ultrasound scans to the baseline ultrasound scan; d. based on the comparison, constructing one or more damage maps representing cell damage within the treatment area thereby providing a predictive model of tissue damage due to the treatment; e. selecting a hypothetical radiation dosage and delivery pattern; and f. using the predictive model, generating a map of expected tissue damage resulting from the hypothetical radiation dosage and delivery pattern. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A system for determining cell condition in response to treatment, the system comprising:
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a storage unit for receiving ultrasound scans of a treatment area, the ultrasound scans comprising; a baseline ultrasound scan; and one or more temporally distinct treatment ultrasound scans of the treatment area taken subsequent to the baseline scan and at various times during a course of treatment sessions; and a comparator module for; (i) comparing the baseline ultrasound scan and at least one of the one or more treatment ultrasound scans (ii) based on the comparison, constructing a plurality of damage maps representing cell condition within the treatment area, thereby providing a predictive model of tissue damage due to the treatment; and an analysis module for; (x) selecting a hypothetical radiation dosage and delivery pattern; and (y) using the predictive model, generating a map of expected tissue damage resulting from the hypothetical radiation dosage and delivery pattern. - View Dependent Claims (20, 21, 22)
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23. An article of manufacture having computer-readable program portions embodied thereon for determining cell condition in response to treatment, the article comprising computer-readable instructions for:
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a. obtaining a plurality of temporally distinct ultrasound scans of a treatment area at various times during a course of treatment sessions; b. comparing the plurality of ultrasound scans; c. constructing a series of damage maps representing cell condition within the treatment area based on the comparison; d. constructing a predictive model of tissue damage due to treatment based on the series of damage maps; e. selecting a hypothetical radiation dosage and delivery pattern; and f. using the predictive model, generating a map of expected tissue damage resulting from the hypothetical radiation dosage and delivery pattern. - View Dependent Claims (24, 25)
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Specification