Sinus delivery of sustained release therapeutics
First Claim
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1. A method for delivering a biodegradable implant into a paranasal sinus cavity comprising:
- a) loading one or more biodegradable implants into a conduit, the conduit having a distal portion and wherein the distal portion is angulated;
b) creating access to the paranasal sinus cavity with the loaded conduit; and
c) delivering the one or more biodegradable implants through an opening in the distal portion of the conduit into the paranasal sinus cavity,wherein the one or more biodegradable implants comprise a therapeutic amount of an active agent for the treatment of sinusitis.
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Abstract
The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
174 Citations
37 Claims
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1. A method for delivering a biodegradable implant into a paranasal sinus cavity comprising:
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a) loading one or more biodegradable implants into a conduit, the conduit having a distal portion and wherein the distal portion is angulated; b) creating access to the paranasal sinus cavity with the loaded conduit; and c) delivering the one or more biodegradable implants through an opening in the distal portion of the conduit into the paranasal sinus cavity, wherein the one or more biodegradable implants comprise a therapeutic amount of an active agent for the treatment of sinusitis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method for delivering a biodegradable implant into a paranasal sinus cavity comprising:
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a) loading one or more biodegradable implants into a conduit, the conduit having a distal portion and wherein the distal portion is angulated at an angle up to about 90 degrees; b) creating access to the paranasal sinus cavity with the loaded conduit; and c) delivering the one or more biodegradable implants through an opening in the distal portion of the conduit into the paranasal sinus cavity, wherein the one or more biodegradable implants comprise a therapeutic amount of an active agent for the reduction of inflammation.
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Specification