Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
First Claim
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1. A method for treating a bone disorder or disease comprising:
- (a) generating a plurality of micro-channels in an area of the skin of a subject;
(b) affixing a printed patch to the area of the skin of the subject, the printed patch comprising a non-adhesive liner and a dried pharmaceutical composition comprising a therapeutically effective amount of a parathyroid hormone (PTH) or a fragment thereof that has PTH activity, and wherein the non-adhesive liner is made of a material that is not permeable to the PTH, and thereby treating the bone disorder or disease.
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Abstract
The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of a peptide or polypeptide that generates hydrophilic micro-channels, and a patch comprising dried therapeutically peptide or polypeptide. Particularly, the system of the present invention facilitates transdermal delivery of parathyroid hormone useful for preventing or treating bone disorders.
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Citations
20 Claims
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1. A method for treating a bone disorder or disease comprising:
- (a) generating a plurality of micro-channels in an area of the skin of a subject;
(b) affixing a printed patch to the area of the skin of the subject, the printed patch comprising a non-adhesive liner and a dried pharmaceutical composition comprising a therapeutically effective amount of a parathyroid hormone (PTH) or a fragment thereof that has PTH activity, and wherein the non-adhesive liner is made of a material that is not permeable to the PTH, and thereby treating the bone disorder or disease. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- (a) generating a plurality of micro-channels in an area of the skin of a subject;
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