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Method for chromatographic finger printing and standardization of single medicines and formulations

  • US 7,662,638 B2
  • Filed: 11/17/2008
  • Issued: 02/16/2010
  • Est. Priority Date: 02/08/2001
  • Status: Expired due to Fees
First Claim
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1. A computer-readable medium storing a computer program for interpreting and manipulating 2-D contour and 3 D chromatograms of an ingredient, said computer program operative to:

  • i) analyze the colored contour image based on the selection of various colors denoting the concentrations of the various constituents eluted with time, and polarity based on retention time;

    ii) analyze the 2-D and 3-D chromatograms of the medicine using all its 3 dimensional properties of the image;

    iii) generate a chromatogram having peaks at various retention times along with conjugative properties of the molecules eluted with time in a specified order of polarity;

    iv) identify the compounds in the said molecules by the UV-Vis absorptive properties of the various constituents in the image;

    v) correlate the reported biological, therapeutic activity of the of various constituents present in the medicines understudy based on the polarity and the conjugative properties of the molecules by dividing the fingerprint into therapeutic zones on X and Y axis;

    vi) generate a barcode for a selected peak(s) using the image coordinates viz., X for retention time, Y for wavelength, R for number of red pixels, G for number of green pixels and B for number of blue pixels, provided by the proposed software;

    vii) generate a database of fingerprints and barcodes for the samples, facilitating all kinds of database utilities like Enterprise Resource Planning (ERP) and Customer Resource Management (CRM) applications; and

    viii) generate a database of the ‘

    display windows’

    for all the samples to be used by the ENTERPRISE RESOURCE PLANNING (ERP) and CUSTOMER RELATIONSHIP MANAGEMENT (CRM) type of business applications.

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