Modified Fc molecules
First Claim
Patent Images
1. A composition of matter of the formula
(X1)a—
- F1—
(X2)b and multimers thereof, wherein;
F1 is an IgG4 Fc domain comprising SEQ ID NO;
607 modified so that it comprises at least one X3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS;
620, 621, 624, 627, 632, 634, 638, 639, 643, and 644 within a loop region of the IgG4 Fc domain, said loop region being in a non-terminal domain of the Fc domain;
X1 and X2 are each independently selected from —
(L1)c—
P1, —
(L1)c—
P1—
(L2)d—
P2, —
(L1)c—
P1—
(L2)d—
P2—
(L3)e—
P3 and —
(L1)c—
P1—
(L2)d—
P2—
(L3)e—
P3—
(L4)f—
P4;
X3 is independently selected from —
(L5)c—
P5, —
(L5)c—
P5—
(L6)d—
P6, —
(L5)c—
P5—
(L6)d—
P6—
(L7)e—
P7, and —
(L5)c—
P5—
(L6)d—
P6—
(L7)e—
P7—
(L8)f—
P8;
P1, P2, P3, and P4 are each independently sequences of pharmacologically active polypeptides or pharmacologically active peptides;
P5, P6, P7, and P8 are each independently sequences of pharmacologically active peptides;
L1, L2, L3, L4, L5, L6, L7, and L8 are each independently linkers; and
a, b, c, d, e, and f are each independently 0 or 1.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.
135 Citations
18 Claims
-
1. A composition of matter of the formula
(X1)a—- F1—
(X2)band multimers thereof, wherein; F1 is an IgG4 Fc domain comprising SEQ ID NO;
607 modified so that it comprises at least one X3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS;
620, 621, 624, 627, 632, 634, 638, 639, 643, and 644 within a loop region of the IgG4 Fc domain, said loop region being in a non-terminal domain of the Fc domain;X1 and X2 are each independently selected from —
(L1)c—
P1, —
(L1)c—
P1—
(L2)d—
P2, —
(L1)c—
P1—
(L2)d—
P2—
(L3)e—
P3 and —
(L1)c—
P1—
(L2)d—
P2—
(L3)e—
P3—
(L4)f—
P4;X3 is independently selected from —
(L5)c—
P5, —
(L5)c—
P5—
(L6)d—
P6, —
(L5)c—
P5—
(L6)d—
P6—
(L7)e—
P7, and —
(L5)c—
P5—
(L6)d—
P6—
(L7)e—
P7—
(L8)f—
P8;P1, P2, P3, and P4 are each independently sequences of pharmacologically active polypeptides or pharmacologically active peptides; P5, P6, P7, and P8 are each independently sequences of pharmacologically active peptides; L1, L2, L3, L4, L5, L6, L7, and L8 are each independently linkers; and a, b, c, d, e, and f are each independently 0 or 1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- F1—
-
10. A modified antibody, comprising an Fc domain, F1, wherein:
-
F1 is an IgG4 Fc domain comprising SEQ ID NO;
607 modified so that it comprises at least one X3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS;
620, 621, 624, 627, 632, 634, 638, 639, 643, and 644 within a loop region of the IgG4 Fc domain, said loop region being in a non-terminal domain of the Fc domain, wherein;X3 is independently selected from —
(L5)c—
P5, —
(L5)c—
P5—
(L6)d—
P6, —
(L5)c—
P5—
(L6)d—
P6—
(L7)e—
P7, and —
(L5)c—
P5—
(L6)d—
P6—
(L7)e—
P7—
(L8)f—
P8;P5, P6, P7, and P8 are each independently sequences of pharmacologically active peptides; L5, L6, L7, and L8 are each independently linkers; and c, d, e, and f are each independently 0 or 1. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
-
Specification