Polypeptide having heparanase activity
First Claim
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1. A preparation comprising protein molecules, said preparation including heparanase (endo-β
- -D-glucuronidase) protein, said heparanase protein having heparanase catalytic activity or being cleavable so as to acquire said heparanase catalytic activity, wherein said heparanase protein comprises SEQ ID NO;
10, provided that said amino acid sequence has a phenylalanine residue instead of a tyrosine residue at position 246, and wherein said preparation is pure enough to elicit anti-heparanase antibodies.
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Abstract
A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
90 Citations
2 Claims
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1. A preparation comprising protein molecules, said preparation including heparanase (endo-β
- -D-glucuronidase) protein, said heparanase protein having heparanase catalytic activity or being cleavable so as to acquire said heparanase catalytic activity, wherein said heparanase protein comprises SEQ ID NO;
10, provided that said amino acid sequence has a phenylalanine residue instead of a tyrosine residue at position 246, and wherein said preparation is pure enough to elicit anti-heparanase antibodies.
- -D-glucuronidase) protein, said heparanase protein having heparanase catalytic activity or being cleavable so as to acquire said heparanase catalytic activity, wherein said heparanase protein comprises SEQ ID NO;
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2. A purified heparanase protein comprising SEQ ID NO:
- 10, provided that said amino acid sequence has a phenylalanine residue instead of a tyrosine residue at position 246.
Specification
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Current AssigneeInsight Biopharmaceuticals Limited
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Original AssigneeHadasit Medical Research Services & Development Ltd (Hadassah, The Women's Zionist Organization of America, Inc.), Insight Biopharmaceuticals Limited
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InventorsPecker, Iris, Vlodavsky, Israel, Feinstein, Elena
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Primary Examiner(s)Hutson; Richard G
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Application NumberUS09/776,874Publication NumberTime in Patent Office3,304 DaysField of Search435/209, 435/200, 435/195, 424/94.61US Class Current435/209CPC Class CodesA61K 38/00 Medicinal preparations cont...C12N 9/2402 hydrolysing O- and S- glyco...C12Y 302/01166 Heparanase (3.2.1.166)
