System and method to accelerate individualized gain adjustment in implantable medical device systems

• US 7,668,593 B1
• Filed: 03/30/2007
• Issued: 02/23/2010
• Est. Priority Date: 03/30/2007
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Pei, Xing, Min, Xiaoyi
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Kimball; Jeremiah T
• Application Number:
  US11/694,534
• Time in Patent Office: 1,061 Days
• Field of Search: 607/7
• US Class Current: 607/7
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control

Abstract

A system and method for increasing the speed of individualizing amplifier gain optimization in implantable medical devices. A variable amplifier gain is initially set at a relatively high level such that the amplifier experiences at least intervals of saturation. A saturation indicator is determined which is indicative of the relative degree of saturation. The gain is then adjusted as a function of the saturation indicator. Relative larger degrees of saturation result in more aggressive gain adjustment. This increases the speed of adjustment with reduced likelihood of loss of sensing. In one implementation, one or more discrete amplifier gain adjustment steps are made in a single adjustment to effectively skip over intermediate adjustments. In another implementation, an estimate is made of a signal peak during a saturating interval. The gain is adjusted directly based on the estimated peak with appropriate sensing safety margins. The method can be implemented with a system including a programmer in communication with an implantable device.

Claims

1. An implantable medical device system comprising:

an implantable sensing electrode configured to sense one or more physiologically based signals;

at least one signal amplifier receiving the physiologically based signals and amplifying these signals by an adjustable amplifier gain; and

a controller receiving the amplified signals and evaluating a patient'"'"'s condition as indicated by the amplified signals, wherein, following an initial implantation, the amplified signals are evaluated and a saturation indicator is calculated and wherein the amplifier gain is adjusted as a function of the saturation indicator so as to inhibit saturation of the signal amplifier with larger saturation indicators resulting in larger gain adjustments;

wherein the saturation indicator is calculated as a ratio of duration of saturation of the at least one signal amplifier to a duration between corresponding zero crossings of a signal baseline.

2. The system of claim 1, wherein the signal amplifier is adjustable by discrete gain settings and wherein one or more of the discrete gain settings are set in the amplifier adjustment.

3. The system of claim 1, further comprising a programmer in communication with the controller and wherein the programmer performs the evaluation of the amplified signals and provides commands to the controller to adjust the amplifier gain as indicated.

4. The system of claim 1, comprising a first and a second signal amplifier wherein the first signal amplifier is configured for narrower band sensing and the second signal amplifier is configured for wider band sensing with different gain settings for the first and second signal amplifiers.

5. The system of claim 4, wherein the first signal amplifier is configured as one of an atrial or ventricular sensing channel and the second signal amplifier is configured to sense an intracardiac electrogram of evoked cardiac response.

6. An implantable medical device system comprising:

an implantable sensing electrode configured to sense one or more physiologically based signals;

at least one signal amplifier receiving the physiologically based signals and amplifying these signals by an adjustable amplifier gain; and

a controller receiving the amplified signals and evaluating a patient'"'"'s condition as indicated by the amplified signals, wherein, following an initial implantation, the amplified signals are evaluated and a saturation indicator is calculated and wherein the amplifier gain is adjusted as a function of the saturation indicator so as to inhibit saturation of the signal amplifier with larger saturation indicators resulting in larger gain adjustments;

wherein the saturation indicator is calculated at least partly based on an extrapolated intersection of adjacent upward going and downward going signal segments.

7. A method of selecting an appropriate gain setting for a signal amplifier for an implanted cardiac stimulation device, the method comprising:

(i) receiving a signal indicative of function of a patient'"'"'s heart wherein the signal is amplified by an amplifier of the implanted cardiac stimulation device;

(ii) selecting at least one characteristic of the signal and calculating a saturation parameter based upon the at least one selected characteristic of the signal;

(iii) automatically determining a gain adjustment value that correlates, at least in part, to the magnitude of the saturation parameter; and

(iv) adjusting the gain of the amplifier by the gain adjustment value;

wherein receiving a signal indicative of the function of the patient'"'"'s heart comprises receiving an IEGM signal and wherein selecting the at least one characteristic of the signal comprises selecting a curve of the IEGM signal that corresponds to a depolarization event of the heart; and

wherein automatically calculating the saturation parameter comprises;

processing the signal to determine a magnitude of a baseline crossing width of the selected curve of the IEGM signal;

processing the signal to determine the magnitude of a saturation width of the selected curve of the IEGM signal; and

determining a ratio between the saturation width and baseline crossing width.

8. The method of claim 7, further comprising repeating acts (i) through (iii) until the saturation parameter indicates that the amplifier is no longer saturating when the heart signal is being received.

9. The method of claim 7, wherein selecting a curve of the IEGM signal indicative of the depolarization event comprises selecting a curve indicative of the R-wave.

10. A method of selecting an appropriate gain setting for a signal amplifier for an implanted cardiac stimulation device, the method comprising:

(i) receiving a signal indicative of function of a patient'"'"'s heart wherein the signal is amplified by an amplifier of the implanted cardiac stimulation device;

(ii) selecting at least one characteristic of the signal and calculating a saturation parameter based upon the at least one selected characteristic of the signal;

(iii) automatically determining a gain adjustment value that correlates, at least in part, to the magnitude of the saturation parameter; and

(iv) adjusting the gain of the amplifier by the gain adjustment value;

wherein receiving a signal indicative of the function of the patient'"'"'s heart comprises receiving an IEGM signal and wherein selecting the at least one characteristic of the signal comprises selecting a curve of the IEGM signal that corresponds to a depolarization event of the heart; and

wherein automatically calculating the saturation parameter comprises using saturation related values to approximate the peak value of the curve indicative of the polarization event.