Cuvette apparatus and system for measuring optical properties of a liquid such as blood

• US 7,671,974 B2
• Filed: 10/29/2004
• Issued: 03/02/2010
• Est. Priority Date: 10/29/2003
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: CHF Solutions, Inc.
• Inventors: Hou, Xinrui, O'Mahony, John J., Merrick, Edwin B.
• Primary Examiner(s): Chowdhury; Tarifur
• Assistant Examiner(s): Pajoohi; Tara S
• Application Number:
  US10/975,411
• Publication Number:
  US 20050094127A1
• Time in Patent Office: 1,950 Days
• Field of Search: 356244-246, 356 39- 42, 356/432, 356/436, 356440-442
• US Class Current: 356/39
• CPC Class Codes: A61B 5/14557 specially adapted to extracorporeal circuits
• CPC Class Codes: G01N 21/05 Flow-through cuvettes G01N21/09 takes precedence; handling fluid samples G01N1/10
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A optical sensor for measuring tranmissive properties of a solution having: a cuvette body with an enclosed flow passage for the solution, wherein the flow passage further includes a solution inlet and a solution outlet and a cuvette between the inlet and outlet; a light source projecting light of a predetermined wavelength through the cuvette and solution flowing through the cuvette and to a light sensor, wherein the cuvette has inner wall surfaces opaque to the light of said predetermined wavelength, and the inner wall is in contact with the solution.

Claims

1. An optical sensor for determining optical properties of a solution, said sensor comprising:

a cuvette body having an enclosed flow passage for the solution, wherein the flow passage further comprises a solution inlet and a solution outlet and a cuvette between the solution inlet and the solution outlet;

opposite sidewalls of the cuvette body included in the flow passage and between the solution inlet and the solution outlet;

a light source projecting light of a predetermined wavelength along a light path through the cuvette to a light sensor, wherein the solution flows through the flow passage of the cuvette body;

transparent windows in each of the opposite sidewalls to the cuvette body and aligned with the light path, wherein a width of each transparent window is narrower than a width of the sidewall, and wherein each sidewall has a inner sidewall surface in contact with the solution and the inner sidewall surface has a length in a direction of flow and the length is longer than the width of the inner sidewall surface of the sidewall, and

wherein the inner sidewall surface is opaque to the light, and wherein each of said transparent windows have a perimeter surrounded by the opaque inner sidewall surface.

2. The device of claim 1 wherein said opposite sidewalls are planar walls defining opposite sides of the flow passage in the cuvette body and the transparent windows are embedded in the planar walls.

3. The device of claim 1 wherein said transparent windows are each a transparent opal disk.

4. The device of claim 1 wherein the solution inlet and the solution outlet of the flow passage are each circular in cross section, and said flow passage further comprises transition sections between the cuvette and each of said solution inlet and said solution outlet.

5. The device of claim 1 wherein the cuvette body is formed of a black plastic material.

6. The device of claim 1 wherein the inner sidewall surfaces of the cuvette are black.

7. The device of claim 1 wherein the solution inlet, flow passage and solution outlet are coaxial.

8. The device of claim 1 wherein the transparent windows are positioned in opposite apertures in said inner sidewall surfaces, and said apertures are optically aligned with the light source and light sensor.

9. The device of claim 8 further comprising optical diffusers fitted into each of said apertures.

10. The device of claim 8 further comprising transparent opal disks fitted into each of said apertures.

11. The device of claim 1 wherein a solution flow direction through the cuvette is orthogonal to a solution flow direction through the solution inlet and the solution outlet.

12. The device of claim 1 wherein the cuvette body further comprises a lamination of opaque plates having opposing slots defining the cuvette.

13. The optical sensor of claim 1 wherein the solution inlet and the solution outlet are perpendicular to the flow passage.

14. The optical sensor of claim 13 wherein the projected light is parallel to the solution inlet and solution outlet.

15. The optical sensor of claim 1 wherein the sidewalls are substantially planar.

16. An optical sensor for determining optical properties of a solution, said sensor comprising:

a cuvette body having an enclosed flow passage for the solution, wherein the flow passage further comprises a solution inlet and a solution outlet and a cuvette between the solution inlet and the solution outlet;

opposite sidewalls of the flow passage, included in the cuvette body and extending between the solution inlet and the solution outlet;

a light source projecting light of a predetermined wavelength along a light path through the cuvette to a light sensor, wherein the solution flows through the flow passage of the cuvette body;

transparent windows in each of the opposite sidewalls of the flow passage and aligned with the light path, wherein a width of each transparent window is narrower than a width of the sidewall, each of the opposite sidewalls has a length in a direction of flow and said length is perpendicular to the width of the sidewall, the length of each sidewall is longer than the width of the sidewall, and said sidewalls are separated from each other by a distance less than one quarter of the width of each of the sidewalls, and

said cuvette body having an inner sidewall surface on each of the opposite sidewalls, wherein the inner sidewall surface is opaque to the light, and said inner sidewall surface is in contact with the solution, and wherein each of said transparent windows have a perimeter surrounded by the opaque sidewall surface.

17. A hematocrit detector for extracorporeal blood comprising:

a cuvette body having an enclosed flow passage for a solution including the extracorporeal blood, wherein said flow passage further comprises a solution inlet, a solution outlet and a cuvette between the solution inlet and the solution outlet;

opposite sidewalls of the flow passage, are included in the cuvette body and are between the solution inlet and the solution outlet;

a light source projecting light of a predetermined wavelength through the cuvette body, the solution flowing through the flow passage and to a light sensor, wherein said predetermined wavelength has a wavelength in a range of about 800 to 930 nm,

the opposite sidewalls each having a transparent window in the cuvette body, wherein each sidewall of the flow passage has a length in a direction of flow and the length is longer than a width of the sidewall, and

said cuvette has an inner sidewall surface of each of the opposite sidewalls opaque to the light of said predetermined wavelength, said inner wall surface is in contact with the solution, and

wherein the transparent windows are aligned with the light source and the light sensor, and each of said transparent windows is narrower than the width of the sidewall and has a perimeter surrounded by the inner wall surface.

18. A hematocrit detector as in claim 17 wherein the light sensor is responsive substantially only to the wavelength of the light of the predetermined wavelength.

19. A hematocrit detector as in claim 17 wherein the light source is cyclically turned on and off at a defined rate, and, during each cycle, said light sensor generates a first signal, in response to detecting the light, when the light source is on and a second signal when the light source is off.

20. A method for detecting blood concentrations in a blood carrying tube using a hematocrit detector having a cuvette, a light source, an optical path extending through the cuvette and a light sensor, said method comprising:

a. connecting the blood carrying tube to blood inlet and to blood outlet of the detector;

b. passing blood from the blood carrying tube and through the blood inlet, a blood flow passage in the cuvette and the blood outlet of the detector, wherein the blood flow passage has opposite sidewalls included in the cuvette, and each of the opposite sidewalls is opaque to light from the light source;

c. while passing the blood through the blood flow passage in the cuvette, projecting the light from the light source through a pair of windows in each of the opposite sidewalls and to the light sensor, wherein the windows each have a width narrower than the sidewall including the window and the windows each have a perimeter surrounded by the the sidewall including the window, and

d. measuring the light projected through the pair of windows and detected by the light sensor to determine a concentration of hematocrit in the blood.

21. A method as in claim 20 further comprising determining a concentration of hemocrit in the blood based on the measured light, and automatically ceasing blood flow through the blood carrying tube if a concentration of hematocrit in the blood is above a predetermined concentration level.

23. A method as in claim 20 further comprising determining a concentration of hemocrit in the blood based on the measured light, and automatically reducing a filtration of the blood if the concentration of the hematocrit is above a predetermined concentration level.

24. A method as in claim 20 wherein said light has a wavelength in a range of about 800 to 930 nm.

22. A method as in 20 further comprising determining a concentration of hemocrit in the blood based on the measured light, and automatically ceasing a filtration of the blood if the concentration of the hematocrit is above a predetermined concentration level.