Noninvasive in vivo measuring system and noninvasive in vivo measuring method by correcting influence of Hemoglobin

• US 7,672,702 B2
• Filed: 03/13/2007
• Issued: 03/02/2010
• Est. Priority Date: 03/13/2007
• Status: Active Grant

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Park, Jae Chan, Kim, Kyung Ho, Hwang, In Duk
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Berhanu; Etsub D
• Application Number:
  US11/717,210
• Publication Number:
  US 20080228050A1
• Time in Patent Office: 1,085 Days
• Field of Search: 600/316, 600/322, 600/334, 600/335
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 21/65 Raman scattering

Abstract

A noninvasive in vivo measuring system and a noninvasive in vivo measuring method are provided. In the noninvasive in vivo measuring system, a Raman-fluorescence measuring unit measures blood sugar concentration, which is measured using Raman spectra before and after applying a pressure on a finger, and outputs a final blood sugar level by correcting the blood sugar concentration measurement according to a Hemoglobin (Hb) concentration measured by an Hb measuring unit.

Claims

1. A noninvasive in vivo measuring system comprising:

a tissue modulation unit configured to apply a pressure on a tissue;

a hemoglobin (Hb) measuring unit configured to analyze an amount of absorption of electromagnetic waves on a first portion of the tissue before and after the application of the pressure by the tissue modulation unit, and configured to measure a Hb concentration of the tissue; and

a Raman-fluorescence (R-F) measuring unit configured to measure a blood sugar concentration by analyzing Raman spectra based on a reflection of a laser irradiated on a second portion of the tissue before and after the application of the pressure by the tissue modulation unit, and configured to calculate a final blood sugar level by correcting the blood sugar concentration measurement, based on the measured Hb concentration,

wherein the R-F measuring unit is configured to calculate the final blood sugar level by increasingly correcting the blood sugar concentration measurement, having been measured based on the Raman spectra, when the Hb concentration is greater than a predetermined threshold value, and is configured to calculate the final blood sugar level by decreasingly correcting the blood sugar concentration measurement, having been measured based on the Raman spectra, when the Hb concentration is less than the predetermined threshold value.

2. The system of claim 1, wherein the Hb measuring unit is configured to calculate the Hb concentration of the tissue by analyzing absorption of predetermined electromagnetic waves before and after the application of the pressure on the tissue.

3. The system of claim 2, wherein wavelengths of the electromagnetic waves before and after the application of the pressure on the tissue are less than approximately 1300 nm.

4. The system of claim 1, wherein the Hb measuring unit comprises:

a light source array, having at least two light sources, to generate the electromagnetic waves;

a light detector configured to sense electromagnetic waves after penetration of the first portion of the tissue by the electromagnetic waves; and

a concentration calculator configured to calculate the Hb concentration using a difference of the absorption of electromagnetic waves, having been sensed by the light detector.

5. The system of claim 4, wherein the light detector is equipped in an instrument for contacting the tissue.

6. The system of claim 5, wherein the tissue modulation unit is configured to apply a predetermined pressure between the instrument for contacting the tissue and a portion of the tissue.

7. The system of claim 5, wherein the tissue modulation unit comprises:

a pressure sensor configured to sense the pressure applied on the portion of the tissue, and configured to be equipped in the instrument for contacting the tissue; and

a pressure applier configured to apply at least a single type of the pressure between the instrument for contacting the tissue and the portion of the tissue by using a result of the sensing, which is fed back from the pressure sensor.

8. The system of claim 1, wherein the R-F measuring unit is configured to calculate the blood sugar concentration by using strengths of fluorescence spectra from the reflection of the laser, and strengths of Raman spectra determined by a glucose component in blood.

9. The system of claim 1, wherein the tissue corresponds to a portion of a finger.

10. A noninvasive in vivo measuring system comprising:

a tissue modulation unit configured to apply a pressure on a tissue;

a Hb measuring unit configured to analyze an amount of reflection of electromagnetic waves, having been irradiated on a first portion of a tissue, before and after the application of pressure by the tissue modulation unit, and measuring Hb concentration of the tissue; and

an R-F measuring unit configured to measure Hb concentration of the tissue by analyzing Raman spectra of reflection of lasers, having been irradiated on a second portion of the tissue, before and after the application of pressure by the tissue modulation unit, and configured to calculate a final blood sugar level by increasingly or decreasingly correcting blood sugar concentration measurement according to the measured Hb concentration,

wherein the Hb measuring unit is configured to identify differences of body fluids in a first portion of the tissue before and after the application of the pressure on the tissue using the reflection of the electromagnetic waves, and is configured to measure the Hb concentration by analyzing differences of absorption with respect to the identified differences of body fluids in the first portion of the tissue.

11. A noninvasive in vivo measuring method comprising:

analyzing an amount of absorption of electromagnetic waves on a first portion of a tissue;

analyzing Raman spectra based on a reflection of a laser irradiated on a second portion of the tissue;

using a tissue modulation unit to apply a pressure on the tissue;

using a hemoglobin (Hb) measuring unit to analyze the amount of absorption of electromagnetic waves on the first portion of the tissue after the applying of the pressure;

using a Raman-fluorescence (R-F) measuring unit to analyze the Raman spectra based on the reflection of the laser irradiated on the second portion of the tissue after the applying of the pressure;

measuring Hb concentration of the tissue using a difference of the absorption of the electromagnetic waves on the first portion of the tissue before and after applying the pressure;

measuring blood sugar concentration of the tissue using a difference of the Raman spectra on the second portion of the tissue before and after the applying of the pressure; and

measuring a final blood sugar level by correcting the blood sugar concentration measurement according to the measured Hb concentration.

12. The method of claim 11, wherein at least two waves, having different absorption rates of the Hb, are used for the electromagnetic waves.

13. The method of claim 12, wherein wavelengths of the electromagnetic waves are less than approximately 1300 nm.

14. The method of claim 11, wherein the final blood sugar level is calculated by increasingly correcting the blood sugar concentration measurement, having been measured based on the Raman spectra, when the Hb concentration is greater than a predetermined threshold value, and wherein the final blood sugar level is calculated by decreasingly correcting the blood sugar concentration measurement, having been measured based on the Raman spectra, when the Hb concentration is less than the predetermined threshold value.

15. The method of claim 11, wherein the blood sugar concentration is calculated using a strength of fluorescence spectra from the reflection of the laser, and using a strength of Raman spectra determined by a glucose component in blood.

16. The method of claim 11, wherein at least one predetermined pressure is applied between an instrument for contacting the tissue and a portion of the tissue.

17. A noninvasive in vivo measuring method comprising:

analyzing an amount of reflection of electromagnetic waves on a first portion of a tissue;

analyzing Raman spectra using reflection of lasers, having been irradiated on a second portion of the tissue;

using a tissue modulation unit to apply a pressure on the tissue;

using a hemoglobin (Hb) measuring unit to analyze an amount of reflection of electromagnetic waves on the first portion of the tissue before and after the applying of the pressure;

using a Raman-fluorescence (R-F) measuring unit to analyze Raman spectra using reflection of lasers, having been irradiated on the second portion of the tissue before and after the applying of the pressure;

measuring Hb concentration of the tissue using a difference of the amount of reflection of electromagnetic waves on the first portion of the tissue before and after the applying of the pressure;

measuring blood sugar concentration of the tissue using a difference of the Raman spectra before and after the applying of the pressure; and

calculating a final blood sugar level by increasingly or decreasingly correcting the measured blood sugar concentration according to the measured Hb concentration.

18. A non-transitory computer-readable storage medium storing a program for implementing a noninvasive in vivo measuring method, the method comprising:

analyzing an amount of absorption of electromagnetic waves on a first portion of a tissue;

analyzing Raman spectra based on a reflection of a laser irradiated on a second portion of the tissue;

applying a pressure on the tissue;

analyzing the amount of absorption of electromagnetic waves on the first portion of the tissue after the applying of the pressure;

analyzing the Raman spectra based on the reflection of the laser irradiated on the second portion of the tissue after the applying of the pressure;

measuring Hb concentration of the tissue using a difference of the absorption of the electromagnetic waves on the first portion of the tissue before and after applying the pressure;

measuring blood sugar concentration of the tissue using a difference of the Raman spectra on the second portion of the tissue before and after the applying of the pressure; and

measuring a final blood sugar level by correcting the blood sugar concentration measurement according to the measured Hb concentration.