Systems and methods for measuring pulse wave velocity with an intravascular device

• US 7,672,706 B2
• Filed: 08/23/2004
• Issued: 03/02/2010
• Est. Priority Date: 08/23/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Sathyanarayana, Shashidhar
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Cheng; Jacqueline
• Application Number:
  US10/924,428
• Publication Number:
  US 20060058653A1
• Time in Patent Office: 2,017 Days
• Field of Search: 600/437, 600/438, 600/481, 600/485, 600/500, 600/407, 600/486, 600/488, 600/504, 600/505
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

The systems and methods described herein allow measurement of the velocity of a pulse wave propagating within a body lumen using an intravascular elongate medical device. The elongate medical device can include a data collection device configured to collect pulse wave data at a location within the lumen. The data collection device is communicatively coupled with a velocity measurement system and configured to output the collected data to the velocity measurement system. The velocity measurement system is configured to calculate the velocity of the pulse wave based on the collected data. The velocity of a pulse wave over a region of the lumen can be used for tissue characterization, diagnosis and the like.

Claims

1. A method of measuring the velocity of anatomical pulse waves propagating within a body lumen, comprising:

collecting data from a first anatomical pulse wave with an intravascular device at a first location within a body lumen, wherein the intravascular device is located within the body lumen, and wherein the anatomical pulse wave data collected at the first location comprises image data of an inner wall of the body lumen at the first location;

collecting data from a second anatomical pulse wave with the intravascular device at a second location within the body lumen, wherein the intravascular device is located within the body lumen, and wherein the anatomical pulse wave data collected at the second location comprises image data of the inner wall of the body lumen at the second location;

wherein the anatomical pulse wave data collected at the first and second locations are collected upon the occurrence of trigger points; and

calculating the velocity of anatomical pulse waves in the region between the first and second locations with the anatomical pulse wave data collected at the first and second locations, wherein the velocity of the anatomical pulse waves are calculated based, at least in part, on the difference in time durations between the occurrence of the first trigger point and the collection of anatomical pulse wave data at the first location and the occurrence of the second trigger point and the collection of anatomical pulse wave data at the second location;

wherein the anatomical pulse wave data collected at the first location and the anatomical pulse wave data collected at the second location are collected from different anatomical pulse waves.

2. The method of claim 1, further comprising calculating the velocity of the anatomical pulse waves along a longitudinal axis of the body lumen.

3. The method of claim 2, further comprising visually mapping the velocity of the anatomical pulse waves along the longitudinal axis of the lumen.

4. The method of claim 1, further comprising calculating the velocity of the anatomical pulse waves along the circumference of the body lumen.

5. The method of claim 1, wherein calculating the velocity of the anatomical pulse waves comprises:

analyzing the image data to determine the temporal variation of the size of the lumen wall at the first and second locations; and

calculating the velocity of the anatomical pulse waves based on the temporal variation of the lumen wall at the first and second locations.

6. The method of claim 5, wherein the anatomical pulse waves are heart pulse waves and the body lumen is a blood vessel.

7. The method of claim 6, further comprising monitoring heart pulse wave output signals prior to collecting data at the first and second locations.

8. The method of claim 6, wherein the heart pulse wave data collected at the first location comprises a first sequence of images of the vessel wall at the first location and the heart pulse wave data collected at the second location comprises a second sequence of images of the vessel wall at the second location.

9. The method of claim 8, wherein the trigger points occur within the heart pulse wave output signal.

10. The method of claim 6, wherein the images in each sequence are collected at fixed intervals.

11. The method of claim 6, wherein the images in each sequence are collected at variable intervals.

12. The method of claim 1, wherein the anatomical pulse wave data collected at the first location comprises pressure data within the body lumen at the first location and wherein the anatomical pulse wave data collected at the second location comprises pressure data within the body lumen at the second location.

13. The method of claim 12, wherein calculating the velocity of the anatomical pulse waves comprises:

analyzing the pressure data at the first and second locations; and

calculating the velocity of the anatomical pulse waves based on the pressure data at the first and second locations.

14. The method of claim 13, wherein the anatomical pulse waves are heart pulse waves, the body lumen is a blood vessel and the pressure data is blood pressure data.

15. The method of claim 14, further comprising monitoring heart pulse wave output signals prior to collecting data at the first and second locations.

16. The method of claim 15, wherein the heart pulse wave data collected at the first location comprises a first sequence of blood pressure measurements at the first location and the heart pulse wave data collected at the second location comprises a second sequence of blood pressure measurements at the second location.

17. The method of claim 16, wherein the blood pressure measurements in each sequence are collected at fixed intervals.

18. The method of claim 16, wherein the blood pressure measurements in each sequence are collected at variable intervals.

19. The method of claim 16, wherein the trigger points occur within the heart pulse wave output signal.

20. The method of claim 1, wherein the anatomical pulse wave data collected at the first and second locations are collected during different cardiac cycles.

21. The method of claim 20, further comprising:

collecting the anatomical pulse wave data at the first location using a transducer during a cardiac cycle;

repositioning the transducer at the second location; and

collecting the anatomical pulse wave data at the second location using the transducer during a subsequent cardiac cycle.

22. The method of claim 1, wherein collecting anatomical pulse wave data with an intravascular device at a first location within a body lumen and collecting anatomical pulse wave data with the intravascular device at a second location within the body lumen comprises the first location and the second location being at different locations from one other along a longitudinal length of the body lumen.

23. The method of claim 1, wherein the velocity of the anatomical pulse waves are calculated based, at least in part, on a change in phase at one or more frequencies of a Fourier spectrum associated with the temporal variation of body lumen area at the first location and at the second location.

24. A medical system for measuring the velocity of anatomical pulse waves propagating within a body lumen, comprising:

an elongate medical device configured for insertion into the body lumen and comprising a data collection device configured to collect data on anatomical pulse waves propagating along the body lumen and output the data to a velocity measurement system, wherein the anatomical pulse wave data comprises image data of an inner wall of the body lumen; and

the velocity measurement system is communicatively coupled with the data collection device and configured to control the data collection device, wherein the velocity measurement system is configured to calculate the velocity of the anatomical pulse waves propagating along the body lumen based on the collected anatomical pulse wave data, wherein the anatomical pulse wave data is collected at a first location upon the occurrence of a first trigger point and at a second location upon the occurrence of a second trigger point, wherein the second location is a known distance from the first location, wherein the velocity of the anatomical pulse waves are calculated based, at least in part, on the difference in time durations between the occurrence of the first trigger point and the collection of anatomical pulse wave data at the first location and the occurrence of the second trigger point and the collection of anatomical pulse wave data at the second location, and wherein the anatomical pulse wave data collected at the first location and the second location are collected from different anatomical pulse waves.

25. The system of claim 24, wherein the elongate medical device comprises an elongate tubular member having an inner lumen configured to slidably receive a central core member, and wherein the imaging device is located on the central core.

26. The system of claim 25, wherein the velocity measurement system is configured to analyze the image data to determine the temporal variation of the vessel wall and calculate the velocity of the anatomical pulse waves between two locations in the vessel based on the temporal variation of the vessel wall at each of the two locations.

27. The system of claim 26, wherein the anatomical pulse waves are heart pulse waves and the body lumen is a blood vessel.

28. The system of claim 27, further comprising a heart monitor communicatively coupled with the velocity measurement system and configured to output a heart monitor signal to the velocity measurement system.

29. The system of claim 28, wherein the heart monitor is an electrocardiogram unit.

30. The system of claim 28, wherein the velocity measurement system is configured to activate the imaging device to collect a sequence of images of the vessel wall upon the occurrence of trigger points in the heart monitor output signal.

31. The system of claim 24, wherein the data collection device further comprises pressure data from a pressure sensor configured to sense the blood pressure within the vessel and wherein the anatomical pulse wave data is blood pressure data.

32. The system of claim 31, wherein the velocity measurement system is configured to analyze the collected anatomical pulse wave data and calculate the velocity of the anatomical pulse waves between two locations in the vessel based on the blood pressure at each of the two locations.

33. The system of claim 32, wherein the anatomical pulse waves are heart pulse waves.

34. The system of claim 33, further comprising a heart monitor communicatively coupled with the velocity measurement system and configured to output a heart monitor signal to the velocity measurement system.

35. The system of claim 34, wherein the heart monitor is an electrocardiogram.

36. The system of claim 34, wherein the velocity measurement system is configured to activate the pressure sensor to collect a sequence of blood pressure measurements upon the occurrence of trigger points in the heart monitor output signal.

37. The system of claim 24, wherein the elongate medical device further comprises a second data collection device communicatively coupled with the velocity measurement system.