Data communication and control for medical imaging systems

• US 7,672,710 B2
• Filed: 08/02/2005
• Issued: 03/02/2010
• Est. Priority Date: 09/21/1994
• Status: Expired due to Fees

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Medrad Incorporated (Bayer AG)
• Inventors: Zelenski, Karen, Rhinehart, Edward J., Uber, Arthur E. III, Sciulli, Francis J., Grumski, Walter, Griffiths, David M., Hirschman, Alan D., Almon-Martin, Rosemary
• Primary Examiner(s): ROBINSON, DANIEL LEON
• Application Number:
  US11/196,806
• Publication Number:
  US 20060030773A1
• Time in Patent Office: 1,673 Days
• Field of Search: 600/431, 600/407, 600/411, 600/432, 600/433, 600/434, 600/435, 600/65, 600/66, 600/67, 600/246, 604/65, 604/66, 604/67, 604/246
• US Class Current: 600/431
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/80 voice-operated command
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/14546 Front-loading type injectors
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS

Abstract

A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

Claims

1. A method of controlling an imaging procedure, the method comprising the steps of:

(a) providing an integrated injection and imaging system featuring an injector subsystem and an imaging subsystem, with the imaging subsystem for applying energy to a patient and producing an image or a measurement of an internal region of the patient from a signal resulting from the energy applied to the patient, and with the injector subsystem having first and second pressurizing units for pressurizing a contrast medium and a diluent, respectively, for injection into the patient in connection with the imaging procedure; and

(b) providing a data interface interconnecting the injector and imaging subsystems for enabling exchange of digital information therebetween, the information comprising at least timing data, such that the digital information transmitted between the subsystems is usable thereby for enabling closed loop control of one of the subsystems by the other of the subsystems through which the contrast medium and the diluent injected into the patient is adjustable so as to achieve a desired level of enhancement therewith within the internal region of the patient of which the images are acquired during the imaging procedure;

wherein the closed loop control of one of the subsystems by the other of the subsystems is based upon at least one of (i) selected portions of the digital information from the imaging subsystem, (ii) selected portions of the digital information from the injector subsystem, and (iii) a physiological condition of the patient obtained from a sensor thereof.

2. The method of claim 1 wherein at least some of the digital information transmitted from the imaging subsystem is usable by the injector subsystem to modify one or more parameters of the injection.

3. The method of claim 2 wherein the injection parameters include at least one of concentration, flow rate, timing, volume, pressure, temperature, time since preparation, brand, type, number of phases, sequencing of mediums, therapeutic progress, and patient recirculation related data.

4. The method of claim 2 wherein the closed loop control enables the injection parameters to be adjusted based on one or more physiological parameters of the patient.

5. The method of claim 2 wherein the injection parameters are stored for use for subsequent or other injection procedures.

6. The method of claim 1 wherein at least some of the digital information transmitted from the injector subsystem is usable by the imaging subsystem to modify one or more parameters of the imaging system.

7. The method of claim 6 wherein the imaging parameters include at least one of power in the energy sent into the patient, time during which the energy is applied to the patient, gain of an amplifier which receives the signal from the patient, or speed at which the energy is scanned across the patient.

8. The method of claim 6 wherein the closed loop control enables the imaging parameters to be adjusted based on one or more physiological parameters of the patient.

9. The method of claim 6 wherein at least some of the digital information transmitted from the imaging subsystem is usable by the injector subsystem to modify one or more parameters of the imaging subsystem.

10. The method of claim 1 wherein the digital information includes control parameters, the control parameters comprising at least one of hold injection, start injection, start scan, stop injection, stop scan, reset injector subsystem, and gating control operation based on feedback from a physiological parameter of the patient.

11. The method of claim 1 wherein the data interface includes:

(a) an injector interface unit associated with the injector subsystem;

(b) an imager interface unit associated with the imaging subsystem; and

(c) an intermediate interface unit linking the injector and imager interface units and thereby enabling the exchange of the information between the injector and imaging subsystems.

12. The method of claim 11 wherein the injector interface unit is for enabling the exchange of a desired portion of the information with at least one of:

(a) a processor unit of the injector subsystem;

(b) an operator interface device associated with the injector subsystem, the operator interface device for use in at least one of entering initial settings, entering at least some of the digital information, entering programming for at least one of the injector and imaging subsystems, and functioning as a display for at least one of the injector and imaging subsystems;

(c) a hospital information system from which additional patient information is receivable and usable thereby as part of the digital information;

(d) a physiological sensor from which a condition of the patient is receivable and usable thereby as part of the digital information; and

(e) a fluid sensor from which a condition of the contrast medium is receivable and usable thereby as part of the digital information.

13. The method of claim 11 wherein the imager interface unit is for enabling the exchange of a desired portion of the information with at least one of:

(a) a processor unit of the imaging subsystem;

(b) an operator interface device associated with the imaging subsystem, the operator interface device for use in at least one of entering initial settings, entering at least some of the digital information, entering programming for at least one of the injector and imaging subsystems, and functioning as a display for at least one of the injector and imaging subsystems;

(c) a hospital information system from which additional patient information is receivable and usable thereby as part of the digital information;

(d) a physiological sensor from which a condition of the patient is receivable and usable thereby as part of the digital information; and

(e) a fluid sensor from which a condition of the contrast medium is receivable and usable thereby as part of the digital information.

14. The method of claim 1 wherein one or more desired portions of the digital information are storable in at least one of the injector subsystem, the imaging subsystem, and an external information system, and retrievable therefrom.

15. The method of claim 1 wherein the data interface is connectable to at least one additional injector subsystem to enable exchange of the digital information therebetween to effect closed loop control of at least one of the injector subsystems by the imaging subsystem.

16. A method of controlling an imaging procedure to enable diagnosis and therapeutic treatment of diseased tissue in a patient, the method comprising the steps of:

(a) providing an injection and imaging system featuring an injector subsystem and an imaging subsystem, with the imaging subsystem capable of applying energy to and producing an image of an internal region of the patient from a signal resulting from the energy applied to the patient, and with the injector subsystem capable of injecting at least one of a contrast medium and a therapeutic agent into the patient in connection with the imaging procedure;

(b) providing a data interface interconnecting the injector and imaging subsystems for enabling exchange of digital information therebetween, the digital information comprising at least timing data;

such that the digital information transmitted between the subsystems is usable thereby for enabling closed loop control of one of the subsystems by the other of the subsystems through which concentration of the contrast medium injected into the patient is adjustable in connection with the imaging procedure during which the images are acquired;

(c) exchanging a desired collection of the digital information between the subsystems and thereby coordinate through the data interface the imaging procedure performed by the imaging subsystem with the injection of the contrast medium into the patient by the injector subsystem to produce a contrast-enhanced image at a desired enhancement level of the internal region including the diseased tissue thereat; and

(d) administering the therapeutic agent via the injector subsystem for the purpose of targeting the diseased tissue for treatment therewith.

17. The method of claim 16 wherein the enhancement of the contrast-enhanced image of the internal region of the patient is stabilized at a target level for a desired period of time to enable the therapeutic agent to be activated thereat.

18. The method of claim 17 wherein the therapeutic agent is activated by at least one of ultrasound, x-ray, electromagnetic, magnetic, and nuclear radiation energy.

19. The method of claim 16 further including the step of connecting a sensor to one of the data interface, the injector subsystem and the imaging subsystem through which a physiological condition of the patient is made available to the system as part of the digital information and usable thereby.

20. The method of claim 19 further including the step of adjusting parameters of at least one of the injection and the imaging procedures based at least in part on feedback obtained from the sensor on the physiological condition of the patient.

21. The method of claim 16 further including the step of connecting a sensor to one of the data interface and the injector subsystem through which a condition of the contrast medium is made available to the system as part of the digital information and usable thereby.

22. The method of claim 21 further including the step of adjusting parameters of at least one of the injection and the imaging procedures based at least in part on feedback obtained from the sensor on the condition of the contrast medium.

23. The method of claim 16 further including the step of transferring to a hospital information system a desired subset of the information pertaining to at least one of the injection of the contrast medium, the administration of the therapeutic agent, and the imaging procedure.

24. The method of claim 16 further including the step of connecting a hospital information system to the data interface through which patient information is exchangeable therebetween and usable thereby as part of the digital information.

25. The method of claim 16 wherein at least some of the digital information transmitted from the imaging subsystem is usable by the injector subsystem to modify one or more parameters of the injection.

26. The method of claim 25 wherein the injection parameters for at least one of the contrast medium and the therapeutic agent include at least one of concentration, flow rate, timing, volume, pressure, temperature, time since preparation, brand, type, number of phases, sequencing of mediums, therapeutic progress, and patient recirculation related data.

27. The method of claim 16 wherein at least some of the digital information transmitted from the injector subsystem is usable by the imaging subsystem to modify one or more parameters of the imaging system.

28. The method of claim 27 wherein the imaging parameters include at least one of power in the energy sent into the patient, time during which the energy is applied to the patient, gain of an amplifier which receives the signal from the patient, or speed at which the energy is scanned across the patient.

29. The method of claim 16 wherein at least some of the digital information transmitted from the imaging subsystem is usable by the injector subsystem to modify one or more parameters of the imaging subsystem.

30. A method of controlling an imaging procedure to enable stress testing of a cardiovascular system of a patient, the method comprising the steps of:

(a) providing an injection and imaging system featuring an injector subsystem and an imaging subsystem, with the imaging subsystem capable of applying energy to and producing an image of an internal region of the patient from a signal resulting from the energy applied to the patient, and with the injector subsystem capable of injecting at least one of a contrast medium and a cardiovascular stressor agent into the patient in connection with the imaging procedure;

(b) providing a data interface interconnecting the injector and imaging subsystems for enabling exchange of digital information therebetween, the information comprising at least timing data;

such that the digital information transmitted between the subsystems is usable thereby for enabling closed loop control of one of the subsystems by the other of the subsystems through which concentration of the contrast medium injected into the patient is adjustable in connection with the imaging procedure during which the images are acquired;

(c) connecting a sensor to one of the data interface, the imaging subsystem and the injector subsystem through which a cardiac condition of the patient is made available to the system as part of the digital information and usable thereby;

(d) exchanging a desired collection of the information between the subsystems and thereby coordinate through the data interface the imaging procedure performed by the imaging subsystem with the injection of the contrast medium into the patient by the injector subsystem to produce a contrast-enhanced image at a desired enhancement level of the internal region; and

(e) administering the cardiovascular stressor agent via the injector subsystem for the purpose of stressing the cardiovascular system.

31. The method of claim 30 further including the step of controlling the administration of the cardiovascular stressor agent based on feedback obtained from the sensor on the cardiac condition of the patient.

32. The method of claim 30 further including the step of adjusting parameters of at least one of the injection and the imaging procedures based on feedback obtained from the sensor on the cardiac condition of the patient.

33. The method of claim 30 further including the step of connecting a contrast sensor to one of the data interface and the injector subsystem through which a condition of the contrast medium is made available to the system as part of the digital information and usable thereby.

34. The method of claim 33 further including the step of adjusting parameters of at least one of the injection and the imaging procedures based at least in part on feedback obtained from the contrast sensor on the condition of the contrast medium.

35. The method of claim 30 wherein the sensor is at least one of a heart rate monitor and a blood pressure monitor.

36. The method of claim 30 wherein the internal region of the patient includes the heart.

37. The method of claim 30 further including the step of adjusting parameters of at least one of the injection and the imaging procedures to stabilize the enhancement of the contrast-enhanced image of the internal region of the patient at a target level for a desired period of time once a target heart rate has been achieved.

38. The method of claim 30 wherein at least some of the digital information transmitted from the imaging subsystem is usable by the injector subsystem to modify one or more parameters of the injection.

39. The method of claim 38 wherein the injection parameters for at least one of the contrast medium and the cardiovascular stressor agent include at least one of concentration, flow rate, timing, volume, pressure, temperature, time since preparation, brand, type, number of phases, sequencing of mediums, and patient recirculation related data.

40. The method of claim 30 wherein at least some of the digital information transmitted from the injector subsystem is usable by the imaging subsystem to modify one or more parameters of the imaging system.

41. The method of claim 40 wherein the imaging parameters include at least one of power in the energy sent into the patient, time during which the energy is applied to the patient, gain of an amplifier which receives the signal from the patient, or speed at which the energy is scanned across the patient.

42. The method of claim 30 wherein at least some of the digital information transmitted from the imaging subsystem is usable by the injector subsystem to modify one or more parameters of the imaging subsystem.

43. The method of claim 30 wherein the digital information includes control parameters, the control parameters comprising at least one of hold injection, start injection, start scan, stop injection, stop scan, reset injector subsystem, and gating control operation based on feedback from a physiological parameter of the patient.