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QT-based system and method for detecting and distinguishing dilated cardiomyopathy and heart failure using an implantable medical device

  • US 7,672,716 B1
  • Filed: 04/03/2006
  • Issued: 03/02/2010
  • Est. Priority Date: 04/03/2006
  • Status: Expired due to Fees
First Claim
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1. A method for detecting an increased risk of dilated cardiomyopathy within a patient for use by an implantable medical device for implant within the patient, the method comprising:

  • detecting values representative of both QT duration and QT dispersion within the patient using the implantable medical device;

    generating a QT dispersion histogram (HQT-dispersion) based on a plurality of QT dispersion values detected over one day;

    generating a QT duration histogram (HQT-duration) based on a plurality of QT duration values detected over one day; and

    calculating a QT dispersion daily mean and a QT duration daily mean using the histogramscalculating an index (QTINDEX) representative of an amount of deviation in QT duration and in QT dispersion values from their respective daily means as follows;

    subtracting the QT dispersion daily mean from each bin value in the QT dispersion histogram (HQT-dispersion);

    subtracting the QT duration daily mean from each bin value in the QT duration histogram (HQT-duration) and multiplying each of the bin values in the QT duration histogram (HQT-duration) by a corresponding QT duration histogram (HQT-duration) bin count; and

    subtracting the QT dispersion daily mean from each bin value in the QT dispersion histogram (HQT-dispersion) and multiplying each of the bin values in the QT dispersion histogram (HQT-dispersion) by a corresponding QT dispersion histogram (HQT-dispersion) bin count; and

    combining the amount of deviation and dispersion to yield the index value (QTINDEX); and

    detecting an increased risk of dilated cardiomyopathy within the patient by comparing the index (QTINDEX) against a threshold (DCTHRESHOLD) indicative of dilated cardiomyopathy.

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