Method and apparatus for optimizing electrical stimulation parameters using heart rate variability

• US 7,672,724 B2
• Filed: 01/18/2005
• Issued: 03/02/2010
• Est. Priority Date: 01/18/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Carlson, Gerrard M., Pastore, Joseph M., Yu, Yinghong, Ding, Jiang, Kramer, Andrew P., Salo, Rodney W.
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US11/037,308
• Publication Number:
  US 20060161208A1
• Time in Patent Office: 1,869 Days
• Field of Search: 600/510, 607/15, 607/17, 607 27- 28, 607/9
• US Class Current: 607/17
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient'"'"'s cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.

Claims

1. A cardiac rhythm management system comprising:

a pulse output circuit to deliver electrical stimulation pulses;

a sensing circuit to sense a cardiac signal;

a heart rate variability (HRV) measurement circuit, coupled to the sensing circuit, to measure a variance in cardiac cycle lengths over a predetermined period of time based on the sensed cardiac signal and to produce an HRV parameter being a measure of the variance; and

a stimulation control circuit, coupled to the pulse output circuit, the sensing circuit, and the HRV measurement circuit, the stimulation control circuit including a stimulation parameter optimization module adapted to adjust at least one stimulation parameter to an approximately optimal value based on the HRV parameter, the stimulation parameter optimization module including;

a stimulation parameter generator adapted to produce a plurality of test values for the at least one stimulation parameter to be tested during a stimulation parameter optimization period, the stimulation parameter generator including a physiologic parameter measurement module adapted to measure at least one physiologic parameter and a dynamic stimulation parameter generator adapted to dynamically produce the plurality of test values during the stimulation parameter optimization period using the at least one physiologic parameter;

a pulse output controller adapted to control delivery of a plurality of series of test pulses of the electrical stimulation pulses using the at least one stimulation parameter during the stimulation parameter optimization period, each series of test pulses of the plurality of series of test pulses associated with a test value of the plurality of test values for the at least one stimulation parameter;

a stimulation parameter selector adapted to select the approximately optimal value for the at least one stimulation parameter from the plurality of test values, the approximately optimal parameter value associated with a maximum variance in cardiac cycle lengths measured for the stimulation parameter optimization period and indicated by the HRV parameter; and

an optimization timer adapted to start and stop the stimulation parameter optimization period.

2. The system of claim 1, wherein the optimization timer is programmed to start the stimulation parameter optimization period on a periodic basis.

3. The system of claim 1, wherein the stimulation parameter generator comprises a physiologic parameter measurement circuit adapted to measure at least one physiologic parameter, and wherein the stimulation parameter generator is adapted to produce the plurality of test values for the at least one stimulation parameter using the at least one physiologic parameter.

4. The system of claim 1, wherein the pulse output controller comprises a stimulation algorithm execution module to control the delivery of the electrical stimulation pulses by executing a stimulation algorithm during the stimulation parameter optimization period.

5. The system of claim 4, wherein the stimulation algorithm execution module comprise a bradycardia pacing algorithm execution module.

6. The system of claim 4, wherein the stimulation algorithm execution module comprise a cardiac resynchronization therapy (CRT) pacing algorithm execution module.

7. The system of claim 4, wherein the stimulation algorithm execution module comprises a remodeling control therapy (RCT) pacing algorithm execution module.

8. The system of claim 4, wherein the stimulation algorithm execution module comprises an autonomic neurostimulation algorithm execution module.

9. The system of claim 4, wherein the stimulation algorithm execution module comprises a combined pacing and neurostimulation algorithm execution module.

10. The system of claim 1, wherein the pulse output circuit comprises a pacing output circuit to deliver cardiac pacing pulses, and the stimulation control circuit comprises a pacing control circuit including a pacing parameter optimization module to adjust at least one pacing parameter to an approximately optimal value based on the HRV parameter.

11. The system of claim 10, wherein the pacing parameter optimization module comprises an atrioventricular delay (AVD) optimization module adapted to optimize one or more AVDs.

12. The system of claim 10, wherein the pacing parameter optimization module comprises an interventricular delay (IVD) optimization module adapted to optimize one or more IVDs.

13. The system of claim 10, wherein the pacing parameter optimization module comprises a pacing site optimization module adapted to optimize a selection of one or more sites to which the cardiac pacing pulses are delivered.

14. The system of claim 1, wherein the pulse output circuit comprises a neurostimulation circuit to deliver neurostimulation pulses, and the stimulation control circuit comprises a neurostimulation control circuit including a neurostimulation parameter optimization module to adjust at least one neurostimulation parameter to an approximately optimal value based on the HRV parameter.

15. The system of claim 14, wherein the neurostimulation parameter optimization module comprises a stimulation pulse frequency optimization module adapted to optimize one or more stimulation pulse frequencies.

16. The system of claim 14, wherein the neurostimulation parameter optimization module comprises a stimulation site optimization module adapted to optimize a selection of one or more sites to which the neurostimulation pulses are delivered.

17. The system of claim 1, wherein the HRV measurement circuit comprises one or more of a Standard Deviation of Normal-to-Normal intervals (SDNN) generator to produce an SDNN, a Standard Deviation of Averages of Normal-to-Normal intervals (SDANN) generator to produce an SDANN, an HRV footprint generator to produce an HRV footprint, and a Root-Mean-Square of Successive Differences (RMSSD) generator to produce an RMSSD.