Methods and apparatus for effectuating a lasting change in a neural-function of a patient

• US 7,672,730 B2
• Filed: 06/24/2003
• Issued: 03/02/2010
• Est. Priority Date: 03/08/2001
• Status: Expired due to Fees

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Inventors: Firlik, Andrew D., Gliner, Bradford Evan, Levy, Alan J., Balzer, Jeffrey
• Primary Examiner(s): Evanisko; George R
• Assistant Examiner(s): ALTER, ALYSSA MARGO
• Application Number:
  US10/606,202
• Publication Number:
  US 20040088024A1
• Time in Patent Office: 2,443 Days
• Field of Search: 607 1- 3, 607/45, 607/46
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36103 Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.

Claims

1. A method for treating a neural function in a brain of a patient, the method comprising:

during at least one therapy session, applying electrical stimulation to a cortical stimulation site and simultaneously having the patient engage in a behavioral therapy, wherein applying electrical stimulation to the stimulation site includes applying electrical stimulation to the stimulation site at a level below a threshold level of neurons at the stimulation site; and

discontinuing the electrical stimulation delivered to the cortical stimulation site after expiration of a therapy period that includes the at least one therapy session.

2. The method of claim 1, further comprising determining a length of the therapy period based on an expected time to recover, develop, or recover and develop a functional ability corresponding to the neural function.

3. The method of claim 1, further comprising identifying the stimulation site in, on, or in and on the brain of the patient.

4. The method of claim 1, further comprising implanting an electrode at least proximate to the stimulation site, and wherein applying electrical stimulation includes applying electrical stimulation by transmitting electrical signals from the electrode.

5. The method of claim 1 wherein having the patient engage in a behavioral therapy comprises having the patient engage in at least one of an activity of daily living, a volitional use of an affected body part, a speech therapy, a visual task, a reading task, a memory task, a comprehension task and an attention task.

6. The method of claim 1, further comprising preventing the electrical stimulation from being delivered to the stimulation site after expiration of the therapy period.

7. The method of claim 1, further comprising selecting the behavioral therapy to include a physical therapy.

8. The method of claim 1 wherein having the patient engage in a behavioral therapy comprises the patient intentionally using a body part in a manner that reinforces the neural function.

9. The method of claim 1, further comprising selecting the behavioral therapy to include a cognitive therapy.

10. The method of claim 1, further comprising selecting the behavioral therapy to include activities of daily living.

11. The method of claim 1, further comprising selecting the behavioral therapy to include a volitional use at an affected body part.

12. The method of claim 1, further comprising selecting the behavioral therapy to include a visual task.

13. The method of claim 1, further comprising selecting the behavioral therapy to include a reading task.

14. The method of claim 1, further comprising selecting the behavioral therapy to include a comprehension task.

15. The method of claim 1, further comprising selecting the behavioral therapy to include an attention task.

17. The method of claim 8 wherein intentionally using a body part in a manner that reinforces the neural function comprises the patient intentionally moving a body part associated with the neural function.

18. The method of claim 17 wherein the patient has had a stroke affecting a hand, arm or leg of the patient, and wherein intentionally moving a body part associated with the neural function comprises the patient intentionally moving at the affected hand, arm or leg.

19. The method of claim 17 wherein the patient has had a stroke affecting speech, and wherein intentionally moving a body part associated with the neural function comprises the patient intentionally speaking.

20. The method of claim 6, further comprising implanting a pulse generator in the patient, implanting an electrode at the cortex, electrically coupling the electrode to the pulse generator, and wherein preventing the electrical stimulation from being delivered to the stimulation site after expiration of the therapy period comprises discontinuing electrical pulses from the pulse generator to the electrode for a period during which the patient retains functional recovery gained during the therapy session.

16. A method for treating a neural function in a brain of a patient, the method comprising:

during at least one therapy session, applying electrical stimulation to a cortical stimulation site at a level below a threshold level of neurons at the stimulation site, and simultaneously having the patient engage in a behavioral therapy; and

discontinuing the electrical stimulation delivered to the cortical stimulation site after expiration of a therapy period that includes the at least one therapy session, wherein discontinuing the electrical stimulation includes discontinuing the electrical stimulation after the patient achieves a predetermined level of functional recovery.