Flow cell for measuring flow rate of a fluid using ultrasonic waves

• US 7,673,527 B2
• Filed: 02/19/2008
• Issued: 03/09/2010
• Est. Priority Date: 02/20/2007
• Status: Active Grant

• Current Assignee: Cytiva Sweden AB (Danaher Corporation)
• Original Assignee: GE Healthcare Bio-Sciences AB (General Electric Company)
• Inventors: Ehring, Hanno, Hermansson, Dan
• Primary Examiner(s): PATEL, HARSHAD R
• Application Number:
  US12/033,130
• Publication Number:
  US 20080196511A1
• Time in Patent Office: 749 Days
• Field of Search: 7386125-86131
• US Class Current: 73/861.28
• CPC Class Codes: G01F 1/662 Constructional details

Abstract

The invention relates to a flow cell for an ultrasonic flow meter comprising two transducers of ultrasonic waves wherein the two transducers are reversibly detachable from the flow cell. The flow cell with the transducers detached is sterilisable and is particularly suitable for use in disposable or single-use systems.

Claims

1. A disposable flow cell (10) for measuring the flow rate of a fluid comprising:

a fluid inlet and a fluid outlet separated by a sample flow-through channel (13) having an essentially straight part (12) therein;

said flow cell includes two transducers (11) of ultrasonic waves axially aligned with each other on opposite sides of said channel (13);

wherein ultrasonic waves transmitted by said transducers travel longitudinally in opposite directions in parallel with the flow direction through said essentially straight part (12) of said channel (13);

the two transducers (11) of ultrasonic waves being reversibly detachable from the flow cell, wherein the angle of refraction of said longitudinal wave at the interface between the essentially straight part (12) of the channel (13) and said fluid is essentially 90°

,

wherein the channel is separated from the transducers (11) of ultrasonic waves by a plug (14) and wherein the flow cell with detached transducers (11) and the plug (14) are both produced from a single polymeric material.

2. The flow cell (10) of claim 1, wherein the essentially straight part (12) of the channel (13) has a length of between 10 and 30 cm.

3. The flow cell (10) of claim 1, wherein the cross section of the essentially straight part (12) of the channel (13) is shaped as a circle and the diameter of the circle is between 4 and 12 mm.

4. The flow cell (10) of claim 1, wherein said polymeric material fulfils the requirements for USP class VI.

5. The flow cell (10) of claim 4, wherein the polymeric material is polymethylpentene (TPX).

6. The flow cell (10) of claim 1, wherein the flow cell with detached transducers (11) has been sterilised by gamma irradiation.

7. The flow cell (10) of claim 1, for use in chromatography or filtration.

8. The flow cell (10) of claim 1, for use in the separation of bio-molecules.