Method of making a variable surface area stent

• US 7,674,493 B2
• Filed: 04/06/2004
• Issued: 03/09/2010
• Est. Priority Date: 04/12/2001
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Cahill, Brian P., Hossainy, Syed, Tang, Fuh-Wei
• Primary Examiner(s): CAMERON, ERMA C
• Application Number:
  US10/819,776
• Publication Number:
  US 20040191404A1
• Time in Patent Office: 2,163 Days
• Field of Search: 427/2.24, 427/2.25
• US Class Current: 427/2.24
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2210/0095 radioactive
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2250/0025 differing in roughness
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir

Abstract

A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.

Claims

1. A method of manufacturing a stent, the stent including a body including a plurality of struts, the struts defining a first end segment of the body, an opposing second end segment of the body, and a middle segment of the body positioned between the first and second end segments, the method comprising depositing a therapeutic agent on the stent so that the first or second end segment has a lesser amount or concentration of the agent than the middle segment as a result of a difference in radius of struts at the first or second end segment as compared to radius of struts at the middle segment.

2. The method of claim 1, wherein depositing the agent comprises applying a composition including a polymer and the agent on the stent.

3. The method of claim 1, wherein a surface area of at least some of the individual struts forming the middle segment of the body is greater than a surface area of the struts forming the first or second end segment so that a greater concentration or amount of the agent is carried by the struts having a greater surface area.

4. The method of claim 1, wherein the term “

radius”

means cross-sectional radius.

5. The method of claim 1, wherein the first or second end segment has the lesser amount or concentration of the agent than the middle segment as a result of a decrease in the radius of the struts at the first or second end segment as compared to the radius of the struts at the middle segment.

6. The method of claim 5, wherein the term “

radius”

means cross-sectional radius.

7. A method of producing a stent, the stent including a body having a first end segment, an opposing second end segment, and a middle segment positioned between the first and second end segments, the method comprising:

manufacturing the stent body so that the first or second end segment has a lesser therapeutic agent loading surface area per unit length of the body than the middle segment, wherein manufacturing the stent body includes forming a plurality of interconnected struts such that a radius of at least some of the individual struts of the first or second end segment is different in size from a radius of the struts of the middle segment; and

depositing a therapeutic agent on the stent so that the first or second end segment has a lesser amount or concentration of the agent than the middle segment as a result of the difference in the radius of the struts.

8. The method of claim 7, wherein the plurality of interconnected struts are formed by cutting a stent pattern from a substrate.

9. The method of claim 8, wherein the cutting is performed by an automated laser method.

10. The method of claim 7, wherein the agent is deposited with a polymeric coating.

11. The method of claim 7, wherein the agent is an anti-coagulant.

12. The method of claim 7, wherein the agent is encased in an anti-coagulant barrier.

13. The method of claim 7, wherein the term “

radius”

means cross-sectional radius.

14. The method of claim 7, wherein the radius of the at least some of the individual struts of the first or second end segment is less than the radius of the struts of the middle segment.

15. The method of claim 14, wherein the term “

radius”

means cross-sectional radius.

16. A method of manufacturing a stent, the stent including a body having a first end segment, an opposing second end segment, and a middle segment positioned between the first and second end segments, the method comprising:

forming a plurality of interconnected struts by cutting a stent pattern from a substrate such that a radius of at least some of the individual struts of the first and second end segments is different in size from a radius of the struts of the middle segment; and

depositing a therapeutic agent on the stent so that the first and second end segments individually have a lesser amount or concentration of the agent than the middle segment as a result of the difference between the radius of the at least some of the individual struts of the first and second end segments and the radius of the struts of the middle segment.

17. The method of claim 16, wherein the term “

radius”

means cross-sectional radius.

18. The method of claim 16, wherein the radius of the at least some of the individual struts of the first and second end segments is less than the radius of the struts of the middle segment.

19. The method of claim 18 wherein the term “

radius”

means cross-sectional radius.