Estrogen beta receptor agonists to prevent or reduce the severity of cardiovascular disease
First Claim
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1. A method for reducing vascular hyperreactivity in vascular muscle cells comprising exposing the vascular muscle cells to an effective amount of a selective estrogen beta receptor agonist that is selected from the group consisting of 5α
- -androstane-3β
,17β
-diol, a derivative of 5α
-androstane-3β
,17β
-diol that has estrogen beta receptor agonist activity, epiestriol, and diarylpropionitrile.
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Abstract
A method for preventing or treating vascular hyperreactivity in which a chemical compound that is an estrogen beta receptor agonist is administered to a subject suffering from or at risk of vascular hyperreactivity. Preferably, the administration is topically to the skin.
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16 Claims
-
1. A method for reducing vascular hyperreactivity in vascular muscle cells comprising exposing the vascular muscle cells to an effective amount of a selective estrogen beta receptor agonist that is selected from the group consisting of 5α
- -androstane-3β
,17β
-diol, a derivative of 5α
-androstane-3β
,17β
-diol that has estrogen beta receptor agonist activity, epiestriol, and diarylpropionitrile. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- -androstane-3β
Specification