Ethylene-carboxyl copolymers as drug delivery matrices

• US 7,678,143 B2
• Filed: 11/12/2003
• Issued: 03/16/2010
• Est. Priority Date: 12/22/2000
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Michal, Gene
• Primary Examiner(s): Stewart; Alvin J
• Application Number:
  US10/712,678
• Publication Number:
  US 20040096504A1
• Time in Patent Office: 2,316 Days
• Field of Search: 623/23.72, 623/23.73, 623/23.74, 623/23.75, 623/23.76, 623/23.6, 623/23.61, 623/23.62, 623/23.63, 623/23.51, 623/1.42, 623/1.15, 623 138- 149, 424484-487, 424/423
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

A coated stent is provided including a coating composed of one or more co-polymers of ethylene with carboxylic acid wherein the carboxylic acid co-monomer content is 5-50 wt %.

Claims

1. A method of coating an implantable medical device, comprising:

adding a copolymer of an ethylene comonomer with a carboxylic acid comonmer to a solvent system to form a composition;

mixing a therapeutic drug with the copolymer composition to allow the drug uniformly dispersed in the copolymer composition, wherein the drug concentration is 5% to 20% by weight;

applying the composition to an implantable medical device; and

allowing the solvent system to evaporate;

wherein the carboxylic acid comonomer content is 5%-50 wt %.

2. The method of claim 1, wherein the carboxylic acid comonomer is selected from a group consisting of acrylic acid, methacrylic acid, maleic acid, itaconic acid, and esters thereof.

3. The method of claim 1, wherein adding the copolymer to the solvent system further comprises neutralizing the copolymer in a volatile or a non-volatile base and dispersing the copolymer in water and/or a co-solvent.

4. The method of claim 1, wherein the solvent system comprises toluene.

5. The method of claim 4, wherein the solvent system further comprises a chlorinated solvent and a lower alcohol.

6. The method of claim 1, wherein the carboxylic acid co-monomer has a content in the copolymer 15% to 40% by weight.

7. The method of claim 1, wherein the co-polymer is ethylene acrylic acid.

8. The method of claim 1, wherein the device comprises a stent.