Detecting atrial fibrillation, method of and apparatus for

• US 7,680,532 B2
• Filed: 02/15/2006
• Issued: 03/16/2010
• Est. Priority Date: 02/25/2005
• Status: Active Grant

• Current Assignee: Joseph Wiesel
• Original Assignee: Joseph Wiesel
• Inventors: Wiesel, Joseph
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/355,050
• Publication Number:
  US 20060195037A1
• Time in Patent Office: 1,490 Days
• Field of Search: 600/508, 600/509, 600/518, 607/4, 607/5, 607/6, 607/14
• US Class Current: 600/518
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/1073 Measuring volume, e.g. of limbs
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation

Abstract

A method and apparatus to determine possible atrial fibrillation or absence of atrial fibrillation that includes detecting pulse rhythms from a succession of time intervals each corresponding to a respective interval of time between successive pulse beats; analyzing the detected pulse rhythms to make a determination of possible atrial fibrillation; indicating the possible atrial fibrillation from the determination; or making a determination of the absence of atrial fibrillation.

Claims

1. A method of determining possible atrial fibrillation, said method comprising:

detecting a sequence of pulse beats to provide a succession of time intervals corresponding to the sequence of pulse beats;

ascertaining a mean of the succession of time intervals;

determining lower and upper boundary values of the time intervals each as a respective percent of the mean;

recalculating the mean based on only the time intervals that are at or between the upper and lower boundary values and not based on the time intervals that are less than the lower boundary value or higher than the upper boundary value;

calculating a standard deviation based on only the time intervals that are at or between the upper and lower boundary values and not based on the time intervals that are less than the lower boundary value or higher than the upper boundary value; and

determining possible atrial fibrillation based upon a quotient formed by dividing the standard deviation by the recalculated mean and comparing the quotient with a threshold value;

if the quotient exceeds the threshold value, the rhythm is atrial fibrillation.

2. The method of claim 1, wherein the lower boundary value is in a range of about 0.50 to about 0.90 times the mean and the upper boundary value is in a range of 1.1 to 1.5 times the mean.

3. The method of claim 1, wherein said threshold value is within the range of 0.01 to 0.10.

4. The method of claim 1, wherein the detecting of the sequence of pulse beats is carried out by using either a sphygmomanometer or a plethysmograph.

5. A method of determining rhythms that are not atrial fibrillation, said method comprising:

detecting a sequence of pulse beats to provide a succession of time intervals corresponding to the sequence of pulse beats;

ascertaining a mean of the succession of time intervals;

determining lower and upper boundary values of the time intervals each as a respective percent of the mean;

recalculating the mean based on only the time intervals that are at or between the upper and lower boundary values and not based on the time intervals that are less than the lower boundary value or higher than the upper boundary value;

calculating a standard deviation based on only the time intervals that are at or between the upper and lower boundary values and not based on the time intervals that are less than the lower boundary value or higher than the upper boundary value; and

determining possible atrial fibrillation based upon a quotient formed by dividing the standard deviation by the recalculated mean and comparing the quotient with a threshold value;

if the quotient is less than the threshold value, the rhythm is not atrial fibrillation.

6. The method of claim 5, where the lower boundary value is in a range of about 0.50 to about 0.90 times the mean and the upper boundary value is in a range of 1.1 to 1.5 times the mean.

7. The method of claim 5, wherein said threshold value is within the range of 0.01 to 0.10.

8. The method of claim 5, wherein the detecting of the sequence of pulse beats is carried out by using either a sphygmomanometer or a plethysmograph.

9. A method of determining possible atrial fibrillation, said method comprising:

sorting a sequence of time intervals between pulse beats by length from shortest to longest or longest to shortest;

determining N where N is the number of time intervals between successive pulse beats;

calculating a first irregularity index I₁ for a first n time intervals of the sorted time intervals, the first n time intervals including a first time interval and at least one additional time interval, the first irregularity index I₁ being a quotient of a mean and a standard deviation of the first n time intervals, wherein n is less than N;

calculating a second irregularity index I₂ for a second n time intervals of the sorted time intervals beginning with a second time interval, the second n time intervals including the second time interval and at least one additional time interval, the second irregularity index I₂ being a quotient of a mean and a standard deviation of the second n time intervals beginning with the second time interval;

continuing to calculate an additional irregularity index I_m of the sorted time intervals for each additional n time intervals in the same manner where m ranges from three until N−

(n−

1); and

determining possible atrial fibrillation based on what percent, P, of the irregularity indices I₁, I₂, . . . I<sub>N−

(n−

1)</sub>, are less than a threshold value T in that if P exceeds a cutoff value, P_cutoff, then the rhythm is considered to show an absence of atrial fibrillation, and if P is less than or equal to the cutoff value, P_cutoff, then the rhythm is considered atrial fibrillation.

10. The method of claim 9, wherein said threshold value T is within the range of about 0.01 to about 0.03.

11. The method of claim 9, wherein said cutoff value, P_cutoff, is within the range of 0.30 to 0.70.

12. An apparatus to determine possible atrial fibrillation, comprising:

means for ascertaining a mean of a succession of time intervals corresponding to that of a sequence of pulse beats;

means for determining lower and upper boundary values of the time intervals as a respective percent of the mean;

means for recalculating a mean of only the time intervals that are at or between the lower and upper boundary values and not the time intervals that are less than the lower boundary value or higher than the upper boundary value and for calculating a standard deviation of only the time intervals that are at or between the lower and upper boundary values and not time intervals that are less than the lower boundary value or higher than the upper boundary value; and

means for determining possible atrial fibrillation based upon a quotient formed by dividing said standard deviation by said recalculated mean and for comparing the quotient with a threshold value.

13. The apparatus of claim 12, further comprising a detector that detects a sequence of pulse beats corresponding to the succession of pulse time intervals.

14. The apparatus of claim 13, wherein the detector is a sphygmomanometer or a plethysmograph.

15. The apparatus of claim 12, wherein the lower boundary value is in a range of about 0.50 to about 0.90 times the mean and the upper boundary value is in a range of 1.1 to 1.5 times the mean.

16. The apparatus of claim 12, wherein said threshold value is within the range of 0.01 to 0.10.

17. An apparatus to determine possible atrial fibrillation, comprising:

means for sorting time intervals between pulse beats by length from shortest to longest or longest to shortest;

means for determining N where N is the number of time intervals between successive pulse beats;

means for calculating a first irregularity index I₁ for a first n time intervals of the sorted time intervals, the first n time intervals including a first time interval and at least one additional time interval, the first irregularity index I₁ being a quotient of a mean and a standard deviation of the first n time intervals, wherein n is less than N;

means for calculating a second irregularity index I₂ for a second n time intervals of the sorted time intervals beginning with a second time interval, the second n time intervals including the second time interval and at least one additional time interval, the second irregularity index I₂ being a quotient of a mean and a standard deviation of the second n time intervals beginning with the second time interval;

means for continuing to calculate an additional irregularity index I_m of the sorted time intervals for each additional n time intervals in the same manner where m ranges from three until N−

(n−

1); and

means for determining possible atrial fibrillation based on what percent, P, of the irregularity indices I₁, I₂, . . . I<sub>N−

(n−

1)</sub>, are less than a threshold value T in that if P exceeds a cutoff value, P_cutoff, then the rhythm is not atrial fibrillation, and if P is less than or equal to the cutoff value, P_cutoff, then the rhythm is atrial fibrillation.