Mixing systems and related mixers

• US 7,682,067 B2
• Filed: 04/20/2006
• Issued: 03/23/2010
• Est. Priority Date: 04/22/2005
• Status: Active Grant

• Current Assignee: Takeda Pharmaceutical Company Limited, Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc., Hyclone Laboratories, Inc. (Danaher Corporation)
• Inventors: Kunas, Kurt Thomas, Jones, Nephi D., Hasan, Fauad F., Larsen, Jeremy K., Oakley, Robert V., Woods, Whitt F., West, Derik R.
• Primary Examiner(s): Sorkin; David L
• Application Number:
  US11/379,535
• Publication Number:
  US 20060280028A1
• Time in Patent Office: 1,433 Days
• Field of Search: 366/251, 366/265, 366/330.1, 366/331
• US Class Current: 366/331
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 2101/44 Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
• CPC Class Codes: B01F 27/071 Fixing of the stirrer to the shaft
• CPC Class Codes: B01F 27/113 Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller
• CPC Class Codes: B01F 27/2121 composed of interconnected parts
• CPC Class Codes: B01F 27/213 characterised by the connection with the drive
• CPC Class Codes: B01F 33/86 Mixing heads comprising a driven stirrer
• CPC Class Codes: B01F 35/51 characterised by their material
• CPC Class Codes: B01F 35/511 provided with liners, e.g. wear resistant or flexible liners
• CPC Class Codes: B01F 35/513 Flexible receptacles, e.g. bags supported by rigid containers

Abstract

A mixing system includes a housing and a motor mount disposed on the housing and having a passage extending therethrough. A dive motor is coupled with the motor mount for selectively rotating the motor mount relative to the housing. A rotational assembly includes a hub having a passageway extending therethrough and a casing at least partially encircling the hub, the hub being rotatable to the casing. The rotational assembly is removably coupled to the housing so that the passageway of the hub aligns with the passage of the motor mount.

Claims

1. A mixing system comprising:

a housing;

a motor mount disposed on the housing and having a passage extending therethrough;

a drive motor coupled with the motor mount for selectively rotating the motor mount relative to the housing; and

a rotational assembly comprising a hub having a passageway extending therethrough and a casing at least partially encircling the hub, the hub being rotatable relative to the casing, the rotational assembly being removably coupled to the housing so that the passageway of the hub aligns with the passage of the motor mount.

2. The mixing system as recited in claim 1, further comprising:

an access recessed on the housing, at least a portion of the access being bounded by a shoulder; and

the casing of the rotational assembly having a flange formed thereon, the rotational assembly being removably received within the access of the housing so that the flange of the casing rests on the shoulder of the access.

3. The mixing system as recited in claim 2, wherein the housing comprises a door that can be selectively closed so as to clamp the rotational assembly within the access of the housing.

4. The mixing system as recited in claim 3, farther comprising a section of resilient elastomeric material lining a portion of the access, the rotational assembly biasing against the elastomeric material when the door is closed.

5. The mixing system as recited in claim 1, farther comprising:

an elongated tubular connector having a first end and an opposing second end, the first end of the connector being connected to the hub; and

an impeller at the second end of the tubular connector

6. The mixing system as recited in claim 5, farther comprising a container having a compartment, the impeller being disposed within the compartment.

7. The mixing system as recited in claim 6, wherein the container comprises a flexible bag secured to the casing of the rotational assembly.

8. The mixing system as recited in claim 6, wherein the container comprises a flexible liner having an open mouth, the connector extending through the open mouth.

9. The mixing system as recited in claim 5, further comprising a drive shaft having a first end and an opposing second end, the second end of the drive shaft being passed through the motor mount, through the hub of the rotational assembly, and through the connector so that the second end of the drive shaft engages with the impeller.

10. The mixing system as recited in claim 9, wherein the first end of the drive shaft engages with the motor mount so that rotation of the motor mount by the drive motor facilitates rotation of the drive shaft.

11. The mixing system as recited in claim 9, further comprising:

the first end of the drive shaft having a first engaging portion with a substantially frustoconical configuration; and

the motor mount having an interior surface bounding the passage extending therethrough, a least a portion of the interior surface forming a second engaging portion having a substantially frustoconical configuration complementary to the first engaging portion, the first engaging portion being received within the second engaging portion.

12. The mixing system as recited in claim 11, wherein one of the first engaging portion and the second engaging portion is comprised of a polymeric material and the other of the first engaging portion and the second engaging portion is comprised of a metal.

13. A mixing system comprising:

a motor mount having a passage extending therethrough;

a drive motor coupled with the motor mount for selectively rotating the motor mount;

a container having a compartment; and

a drive shaft having a first end and an opposing second end, the first end of the drive shaft having a first engaging portion with a substantially frustoconical configuration, the drive shafted being passed through the passage of the motor mount so that the first engaging portion of the drive shaft is at least partially disposed within the passage of the motor mount and the second end of the drive shaft is disposed within the compartment of the container.

14. The mixing system as recited in claim 13, the motor mount having an interior surface bounding the passage extending therethrough, at least a portion of the interior surface forming a second engaging portion having a substantially frustoconical configuration complementary to the first engaging portion, the first engaging portion being received within the second engaging portion.

15. The mixing system as recited in claim 14, wherein one of the first engaging portion and the second engaging portion is comprised of a polymeric material and the other of the first engaging portion and the second engaging portion is comprised of a metal.

16. The mixing system as recited in claim 13, wherein the drive shaft comprises:

a head section that includes the first engaging portion, the head section being comprised of a polymeric material; and

a shaft section that includes the second end of the drive shaft, the shaft section being comprised of a metal, the head section and the shaft section being connected together.

17. The mixing system as recited in claim 13, further comprising:

a housing; and

a rotational assembly comprising a hub having a passageway extending therethrough and a casing at least partially encircling the hub, the hub being rotatable relative to the casing, the rotational assembly being removably coupled to the housing so that the passageway of the hub aligns with the passage of the motor mount.

18. The mixing system as recited in claim 17, further comprising:

an access recessed in the housing, at least a portion of the access being bounded by a shoulder; and

the casing of the rotational assembly having a flange formed thereon, the rotational assembly being removably received within the access of the housing so that the flange of the casing rests on the shoulder of the access.

19. The mixing system as recited in claim 18, wherein the housing comprises a door that can be selectively closed so as to clamp the rotational assembly within the access of the housing.

20. The mixing system as recited in claim 17, wherein the motor mount is rotatably coupled with the housing.

21. The mixing system as recited in claim 17, further comprising:

an elongated tubular connector having a first end and an opposing second end, the first end of the connector being connected to the hub; and

an impeller at the second end of the tubular connector.

22. The mixing system as recited in claim 21, further comprising a container having a compartment, the impeller being disposed within the compartment.

23. The mixing system as recited in claim 22, wherein the container comprises a flexible bag secured to the casing of the rotational assembly.

24. The mixing system as recited in claim 22, wherein the container comprises a flexible liner having an open mouth, the connector extending through the open mouth.

25. The mixing system as recited in claim 21, wherein the second end of the drive shaft is passed through the motor mount, through the hub of the rotational assembly, and through the connector so that the second end of the drive shaft engages with the impeller.

26. The mixing system as recited in claim 25, wherein the first end of the drive shaft engages with the motor mount so that rotation of the motor mount by the drive motor facilitates rotation of the drive shaft.

27. The mixing system as recited in claim 25, wherein the drive shaft engages the hub so that rotation of the drive shaft facilitates rotation of the hub relative to the casing.

28. A mixing system comprising:

an elongated tubular connector having an interior surface bounding a passage extending between a first end and an opposing second end;

an impeller disposed at the second end of the tubular connector;

an elongated drive shaft having a first end and an opposing second end, the second end of the drive shaft being passed through the passage of the tubular connector to engage with the impeller so that rotation of the drive shaft facilitates concurrent rotation of the impeller and tubular connector, the first end of the drive shaft being disposed outside of the passage of the tubular connector;

means for securing the first end of the tubular connector to the drive shaft;

means for selectively rotating the drive shaft.

29. The mixing system as recited in claim 28, wherein the means for securing is mounted on the tubular connector and radially inwardly biases the tubular connector against the drive shaft.

30. The mixing system as recited in claim 28, wherein the means for securing comprises a clamp mounted on the tubular connector.

31. The mixing system as recited in claim 28, further comprising a container having a compartment, the impeller being disposed within the compartment.

32. The mixing system as recited in claim 31, wherein the container comprises a flexible liner having an open mouth, the connector freely extending through the open mouth.

33. The mixing system as recited in claim 32, further comprising a rigid support housing, the liner being at least partially disposed within the rigid support housing.

34. The mixing system as recited in claim 28, wherein the means for selectively rotating the drive shaft.

35. The mixing system as recited in claim 28, wherein the means for selectively rotating the drive shaft comprises:

a housing;

a motor mount disposed on the housing and having a passage extending therethrough; and

a drive motor coupled with the motor mount for selectively rotating the motor mount relative to the housing, at least a portion of the drive shaft engaging the motor mount such that rotation of the motor mount facilitates rotation of the drive shaft.