System for sensing, diagnosing and treating physiological conditions and methods

• US 7,682,312 B2
• Filed: 12/03/2007
• Issued: 03/23/2010
• Est. Priority Date: 09/20/2002
• Status: Expired due to Fees

• Current Assignee: Zoll Medical Corporation (Asahi Kasei Corporation)
• Original Assignee: Advanced Circulatory Systems, Inc. (Asahi Kasei Corporation)
• Inventors: Lurie, Keith
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US11/949,490
• Publication Number:
  US 20080108905A1
• Time in Patent Office: 841 Days
• Field of Search: None
• US Class Current: 600/481
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing

Abstract

One method for diagnosing a cardiovascular-related condition in a breathing person comprises interfacing a valve system to the person'"'"'s airway. The valve system is configured to decrease or prevent respiratory gas flow to the person'"'"'s lungs during at least a portion of an inhalation event. The person is permitted to inhale and exhale through the valve system. During inhalation, the valve system functions to produce a vacuum within the thorax to increase blood flow back to the right heart of the person, thereby increasing blood circulation and blood pressure. Further, at least one physiological parameter is measured both prior to and while the person inhales and exhales through the valve system. The measured parameters are evaluated to confirm the initial diagnosis of a cardiovascular condition.

Claims

1. A method for diagnosing a cardiovascular-related condition in a breathing person, the method comprising:

measuring a physiological parameter of the person at a first time;

diagnosing a cardiovascular condition of the person based on the physiological parameter that was measured at the first time;

interfacing a valve System to the person'"'"'s airway, the valve, system being configured to decrease or prevent respiratory gas flow to the person'"'"'s lungs during at least a portion of an inhalation event;

permitting the person to inhale and exhale through the valve system, wherein during inhalation the valve system functions to produce a vacuum within the thorax to increase blood flow back to the right heart of the person, thereby increasing blood circulation and blood pressure;

measuring the physiological parameter a second time while the person inhales and exhales through the valve system;

comparing, with a processor, the measured physiological parameter at the first time and the second time to evaluate the effect of the valve system on the diagnosed cardiovascular condition.

2. A method as in claim 1, further comprising determining whether to continue permitting the person to inhale and exhale through the valve system based on the comparison.

3. A method as in claim 1, further comprising performing the comparison of the measured physiological parameters using a computer.

4. A method as in claim 1, wherein the valve system is incorporated into a racial mask, and further comprising coupling the facial mask to the person'"'"'s face.

5. A method as in claim 1 wherein the valve system include a pressure responsive inflow valve, and further comprising setting an actuating pressure of the valve to be in the range from about 0 cm H₂O to about −

50 cm H₂O.

6. A method as in claim 5, further comprising increasing or decreasing the actuating pressure over time, and re-measuring the physiological parameter.

7. A method as in claim 1, wherein the valve system is further configured to prevent or decrease exhaled gases from exiting the person'"'"'s lungs during at least a portion of an exhalation, and further comprising measuring the physiological parameter following an exhalation.

8. A method as in claim 1 wherein the physiological parameter is measured by an imaging or mapping technique.

9. A method as in claim 8, wherein the imaging or mapping technique is selected from a group consisting of ECG, echo-imaging of the heart, imaging of radio-labeled markers in the blood, MRI imaging, CT imaging and imaging of markers for cardiac ischemic.

10. A method as in claim 1, wherein the measured physiological parameter is selected from a group consisting of blood pressure, expired CO₂, heart rate, air flow and pressure through the airway and lungs, oxygen saturation, blood levels of O₂, blood lactate, blood pH, tissue lactate, tissue pH and body temperature.

11. A method as in claim 1, wherein the measured physiological parameter comprises one or more markers of cardiac ischemia.

12. A method as in claim 1, further comprising introducing a substance into the person to stress the person'"'"'s heart.

13. A method as in claim 12, wherein the substance comprises a volume load of saline solution that is injected into the person'"'"'s blood stream.

14. A method as in claim 12, wherein the substance comprises nitroglycerine that is injected into the person to lower the person'"'"'s blood pressure.

15. A method as in claim 12, wherein the substance comprises a drug that is injected into the person and is selected from a group of drugs consisting of adenosine, adrenaline and dobutamine.

16. A system for diagnosing a cardiovascular-related condition in a breathing person, the system comprising:

a valve system that is capable of being coupled to the person'"'"'s airway, the valve system being configured to decrease or prevent respiratory gas flow to the person'"'"'s lungs during at least a portion of an inhalation event to produce a vacuum within the thorax to increase blood flow back to the right heart of the person, thereby increasing blood circulation and blood pressure; and

a controller that is configured to record a physiological parameter of the person at a first time prior to breathing through the valve system and to diagnose a cardiovascular condition of the person based on the physiological parameter that was measured at the first time, to record the physiological parameter a second time that was obtained while the person inhaled and exhaled through the valve system, and to compare the measured physiological parameter at the first time and the second time to evaluate the effect of the valve system on the diagnosed cardiovascular condition.

17. A system as in claim 16, wherein the controller is further configured to change the configuration of the valve system over time to vary he level of inspiratory impedance.

18. A system as in claim 16, wherein the controller is further configured to change the configuration of the valve system based on the measured parameters.

19. A system as in claim 16, wherein the valve system is configured to prevent or decrease exhaled gases from exiting the person'"'"'s lungs during at least a portion of an exhalation and is incorporated into a facial mask.

20. A system as in claim 16, wherein the valve system includes a pressure responsive inflow valve that has an actuating pressure in the range from about 0 cm H₂O to about −

50 cm H₂O.

21. A system as in claim 16, further comprising at least one sensor that is coupled to the controller, wherein the sensor is selected from a group consisting of blood pressure sensors, expired CO₂ sensors, heart rate sensors, air flow and pressure sensors, oxygen saturation sensors, O₂ blood level sensors, blood lactate sensors, blood pH sensors, tissue lactate sensors, tissue pH sensors and body temperature sensors.