Methods to accelerate wound healing in thoracic anastomosis applications

• US 7,682,332 B2
• Filed: 06/30/2004
• Issued: 03/23/2010
• Est. Priority Date: 07/15/2003
• Status: Expired due to Fees

• Current Assignee: Portaero, Inc
• Original Assignee: Portaero, Inc
• Inventors: Tanaka, Don
• Primary Examiner(s): Wax; Robert A
• Assistant Examiner(s): BARHAM, BETHANY P
• Application Number:
  US10/881,408
• Publication Number:
  US 20050025816A1
• Time in Patent Office: 2,092 Days
• Field of Search: 604/19, 424/443
• US Class Current: 604/19
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 2017/1103 Approximator
• CPC Class Codes: A61M 1/04 Artificial pneumothorax apparatus
• CPC Class Codes: A61M 16/0406 implanted flow modifiers
• CPC Class Codes: A61M 16/101 using an oxygen concentrator
• CPC Class Codes: A61M 16/106 in a path
• CPC Class Codes: A61M 2039/0252 for access to the lungs
• CPC Class Codes: A61M 2039/0297 at least part of it being inflatable, e.g. for anchoring, sealing or removing
• CPC Class Codes: A61M 2202/0007 introduced into the body
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/03 Gases in liquid phase, e.g. cryogenic liquids
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053

Abstract

Methods for creating an anastomosis between a channel through the chest wall and an opening in the visceral membrane of a lung using a medical device. The methods include creating the channel through the chest wall into the pleural cavity; forming an adhesion between the chest wall and the visceral membrane of the lung; creating an opening in the visceral membrane of the lung which communicates with the channel; and inserting the medical device into the channel. The medical device has a compression structure which spans the channel. The methods include configuring the compression structure to apply a compressive force to tissue surrounding the anastomosis and/or applying agents and materials to the tissue of the anastomosis thereby accelerating the formation and healing of the anastomosis.

Claims

1. A method for creating an anastomosis which comprises a channel through a chest wall joined to an opening in a visceral membrane of a lung using a medical device having a compression structure, the method comprising:

(a) creating the channel through the chest wall into a pleural space surrounding the lung;

(b) forming an adhesion between the chest wall and a visceral membrane of the lung to seal the channel from the pleural space;

(c) creating an opening in the visceral membrane of the lung which communicates with the channel; and

(d) inserting the medical device through the channel and opening such that a first portion of the compression structure is outside the chest wall, a second portion of the compression structure is inside the lung, and a third portion of the compression structure is within the channel; and

(e) configuring the compression structure so that the compression structure maintains a compressive force upon tissue surrounding the channel.

2. The method of claim 1, wherein step (e) comprises:

(e) configuring the compression structure after inserting the medical device through the channel and opening.

3. The method of claim 1, wherein step (e) comprises:

(e) configuring the compression structure so that a compressive force is applied upon tissue surrounding the channel by at least the first portion and second portion of the medical device.

4. A method for creating an anastomosis which comprises a channel through a chest wall joined to an opening in a visceral membrane of a lung using a fibrosis accelerating component, the method comprising:

(a) creating the channel through the chest wall into a pleural space surrounding the lung;

(b) forming an adhesion between the chest wall and a visceral membrane of the lung to seal the channel from the pleural space;

(c) creating an opening in the visceral membrane of the lung which communicates with the channel; and

(d) inserting the fibrosis accelerating component in the channel such that it is in contact with newly exposed tissue of the channel.

5. The method of claim 4, wherein step (b) comprises forming an adhesion between the chest wall and a visceral membrane of the lung using a biocompatible adhesive to seal the channel from the pleural space.

6. The method of claim 4, wherein the fibrosis accelerating component comprises a porous fabric and wherein the method further comprises:

(e) attaching the fabric fibrosis accelerating component to the newly exposed tissue of the channel utilizing one or more sutures.

7. The method of claim 4, wherein the fibrosis accelerating component comprises a porous fabric and wherein the method further comprises:

(e) attaching the fabric fibrosis accelerating component to the newly exposed tissue of the channel utilizing an adhesive.

8. The method of claim 4, wherein the fibrosis accelerating component comprises a porous fabric and wherein the method further comprises:

(e) attaching the fabric fibrosis accelerating component to the newly exposed tissue of the channel utilizing one or more staples.

9. The method of claim 4, wherein the fibrosis accelerating component comprises a fabric treated with an antibiotic and wherein the method further comprises:

(e) delivering the antibiotic to the anastomosis to reduce the risk of infection.

10. The method of claim 4, wherein the fibrosis accelerating component comprises a fabric treated with a wound healing agent wherein the method further comprises:

(e) delivering the wound healing agent to the anastomosis to enhance healing.

11. A method for creating an anastomosis which comprises a channel through a chest wall joined to an opening in a visceral membrane of a lung, the method comprising:

(a) creating the channel through the chest wall into a pleural space surrounding the lung;

(b) forming an adhesion between the chest wall and a visceral membrane of the lung to seal the channel from the pleural space;

(c) creating an opening in the visceral membrane of the lung which communicates with the channel; and

(d) receiving a medical device having a compression structure;

(e) inserting the medical device into the channel and opening such that a first portion of the compression structure is outside the chest wall, a second portion of the compression structure is inside the lung, and a third portion of the compression structure is within the channel; and

(f) configuring the compression structure so that the compression structure maintains a compressive force upon tissue surrounding the channel.

12. The method of claim 11, wherein;

step (d) comprises receiving a medical device having a compression structure and one or more agents for accelerating a fibrotic response releasably affixed to the compression structure; and

wherein the method further comprises

(f) delivering the one or more agents for accelerating a fibrotic response to the channel.

13. The method of claim 11, wherein;

step (d) comprises receiving a medical device having a compression structure and one or more agents for reducing a risk of infection releasably affixed to the compression structure; and

wherein the method further comprises

(f) delivering the one or more agents for reducing a risk of infection to the channel.

14. The method of claim 11, wherein;

step (d) comprises receiving a medical device having a compression structure and one or more agents for promoting wound healing releasably affixed to the compression structure; and

wherein the method further comprises

(f) delivering the one or more agents for promoting wound healing to the channel.

15. A method for creating an anastomosis which comprises a channel through a chest wall joined to an opening in a visceral membrane of a lung, the method comprising:

(a) creating the channel through the chest wall into a pleural space surrounding the lung;

(b) forming an adhesion between the chest wall and a visceral membrane of the lung to seal the channel from the pleural space;

(c) creating an opening in the visceral membrane of the lung which communicates with the channel; and

(d) receiving a medical device having a compression structure and one or more drugs releasably affixed to the compression structure;

(e) inserting the medical device into the channel such that a first portion of the compression structure is outside the chest wall, a second portion of the compression structure is inside the chest wall, and a third portion of the compression structure is within the channel;

(f) configuring the compression structure so that the compression structure maintains a compressive force upon tissue surrounding the channel; and

(g) delivering the one or more drugs to the channel.

16. A method for creating an anastomosis which comprises a channel through a chest wall joined to an opening in a visceral membrane of a lung, the method comprising:

(a) creating the channel through the chest wall into a pleural space surrounding the lung;

(b) forming an adhesion between the chest wall and a visceral membrane of the lung to seal the channel from the pleural space;

(c) creating an opening in the visceral membrane of the lung which communicates with the channel; and

(d) receiving a medical device having a compression structure;

(e) inserting the medical device into the channel such that a first portion of the compression structure engages an external surface of the chest wall, a second portion of the compression structure engages the lung, and a third portion of the compression structure engages the channel; and

(f) adjusting a spacing between the first portion of the compression structure and the second portion of the compression structure to apply a compressive force upon tissue surrounding the channel.

17. A method for treating an anastomosis which comprises a channel through a chest wall joined to an opening in a visceral membrane of a lung, wherein the anastomosis was created by (a) creating the channel through the chest wall into a pleural space surrounding the lung, (b) forming an adhesion between the chest wall and a visceral membrane of the lung to seal the channel from the pleural space, (c) creating an opening in the visceral membrane of the lung which communicates with the channel, and wherein the method for treating the anastomosis comprises the steps of:

(d) receiving a medical device comprising an adjustable clamp which includes a first plate, a second plate and an adjustable spacer that controls the spacing between the first plate and the second plate;

(e) inserting the adjustable clamp into the channel such that the first plate engages an external surface of the chest wall, the second plate engages the visceral membrane; and

(f) adjusting the adjustable spacer such that the first plate and second plate apply a compressive force upon tissue surrounding the channel.

18. The method of claim 17, wherein step (d) comprises receiving a medical device having an adjustable clamp which includes one or more agents for accelerating a fibrotic response releasably affixed to the adjustable clamp;

and the method further comprises;

(g) delivering the one or more agents for accelerating a fibrotic response to the channel.

19. The method of claim 17, wherein step (d) comprises receiving a medical device having an adjustable clamp which includes one or more agents for reducing a risk of infection releasably affixed to the adjustable clamp;

and the method further comprises;

(g) delivering the one or more agents for reducing a risk of infection to the channel.

20. The method of claim 17, wherein step (d) comprises receiving a medical device having an adjustable clamp which includes one or more agents for promoting wound healing releasably affixed to the adjustable clamp;

and the method further comprises;

(g) delivering the one or more agents for promoting wound healing to the channel.

21. A method for treating an anastomosis which comprises (a) a channel through a chest wall, (b) an adhesion between the chest wall and a visceral membrane of a lung to seal a channel from a pleural space, and (c) an opening in the visceral membrane of the lung which communicates with the channel, and wherein the method for treating the anastomosis comprises the steps of:

(d) receiving a medical device comprising a compression structure adapted to treat the anastomosis;

(e) inserting the medical device through the anastomosis such that a first portion of the compression structure is outside the chest wall, a second portion of the compression structure is inside the lung, and a third portion of the compression structure is within the channel; and

(f) configuring the compression structure so that the compression structure maintains a compressive force upon tissue surrounding the anastomosis.

22. The method of claim 21, wherein step (d) comprises receiving a medical device having a compression structure and one or more agents for accelerating a fibrotic response releasably affixed to the compression structure;

and wherein the method for treating an anastomosis further comprises;

(g) delivering the one or more agents for accelerating a fibrotic response to the channel.

23. The method of claim 21, wherein step (d) comprises receiving a medical device having a compression structure and one or more agents for reducing a risk of infection releasably affixed to the compression structure;

and wherein the method for treating an anastomosis further comprises;

(g) delivering the one or more agents for reducing a risk of infection to the channel.

24. A method for treating an anastomosis which comprises (a) a channel through a chest wall, (b) an adhesion between the chest wall and a visceral membrane of the lung to seal the channel from a pleural space, and (c) an opening in the visceral membrane of the lung which communicates with the channel, and wherein the method for treating the anastomosis comprises:

(d) receiving a fibrosis accelerating component configured to fit the anastomosis and adapted to enhance fibrosis in tissues of the anastomosis; and

(e) inserting the fibrosis accelerating component in the channel such that it is in contact with newly exposed tissue of the anastomosis.

25. The method of claim 24, wherein the fibrosis accelerating component comprises a porous fabric and wherein the method further comprises:

(f) attaching the fabric fibrosis accelerating component to the newly exposed tissue of the channel utilizing one or more sutures.

26. The method of claim 24, wherein the fibrosis accelerating component comprises a porous fabric and wherein the method further comprises:

(f) attaching the fabric fibrosis accelerating component to the newly exposed tissue of the channel utilizing an adhesive.

27. The method of claim 24, wherein the fibrosis accelerating component comprises a porous fabric and wherein the method further comprises:

(f) attaching the fabric fibrosis accelerating component to the newly exposed tissue of the channel utilizing one or more staples.

28. The method of claim 24, wherein the fibrosis accelerating component comprises a fabric treated with an antibiotic and wherein the method further comprises:

(f) delivering the antibiotic to the anastomosis to reduce risk of infection.

29. The method of claim 24, wherein the fibrosis accelerating component comprises a fabric treated with a wound healing agent wherein the method further comprises:

(f) delivering the wound healing agent to the anastomosis to enhance healing.