Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
First Claim
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1. A method for immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising:
- preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent;
applying the base coat mixture directly to the implantable medical device;
polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization;
applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer; and
immobilizing the anti-thrombogenic material directly to chemically functional groups in the binding material within the base coat layer on the surface of the medical device,wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, andwherein the anti-thrombogenic material is selected from the group consisting of glycosaminoglycans, superoxide dismutase mimetic (SODm) grafted to heparin, and combinations thereof.
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Abstract
The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.
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Citations
16 Claims
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1. A method for immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising:
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preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent; applying the base coat mixture directly to the implantable medical device; polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization; applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer; and immobilizing the anti-thrombogenic material directly to chemically functional groups in the binding material within the base coat layer on the surface of the medical device, wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, and wherein the anti-thrombogenic material is selected from the group consisting of glycosaminoglycans, superoxide dismutase mimetic (SODm) grafted to heparin, and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for end-immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising:
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preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent; applying the base coat mixture directly to the implantable medical device; polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization; applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer; and end-immobilizing the anti-thrombogenic material, through a group that terminates the anti-thrombogenic material, directly to chemically functional groups in the binding material within the base coat layer on the surface of the medical device, wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, and wherein the anti-thrombogenic material is selected from the group consisting of glycosaminoglycans, superoxide dismutase mimetic (SODm) grafted to heparin, and combinations thereof. - View Dependent Claims (13, 14, 15)
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16. A method for immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising:
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preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent; applying the base coat mixture directly to the implantable medical device; polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization; applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer; and immobilizing the anti-thrombogenic material directly to chemically functional groups in the binding material within the base coat layer on the medical device, wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, and wherein the anti-thrombogenic material comprises a superoxide dismutase mimetic (SODm), grafted to heparin.
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Specification