Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin
First Claim
1. An aerosol generating device, comprising:
- a liquid source of a liquid aerosol formulation comprising a high volatility carrier and insulin;
a flow passage in fluid communication with the liquid source wherein the flow passage has an outlet which opens into ambient air;
a heater disposed to heat the liquid aerosol formulation in a heated portion of the flow passage to 100 to 150°
C. to produce a vapor which exits the flow passage outlet and admixes with ambient air to produce a dry powder aerosol;
a power supply; and
a controller operable to deliver a dose of the liquid aerosol formulation to the flow passage and control power from the power supply to the heater so as to maintain the heater at a temperature range of 100 to 150°
C. effective to vaporize the liquid aerosol formulation in the flow passage and produce an emitted dose of the dry powder aerosol in ambient air,wherein the aerosol generator is operable to achieve a respirable fraction of at least 70% of the emitted dose.
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Accused Products
Abstract
Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of the carrier. The carrier can be a mixture of ethanol and water and the liquid aerosol formulation can be propellant free. An aerosol generating device generates the aerosolized insulin by passing the liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor which entrains insulin particles which mix with air to form an aerosol. The insulin particles can be dry insulin particles produced by a hand held inhaler. By controlling the concentration of the insulin in the formulation, the size of the flow passage and/or the amount of heat which heats the flow passage, the aerosol can be provided with a selected mass median aerodynamic diameter of 1 to 3 μm or less than 1 μm so as to be delivered to a targeted portion of the lung using the inhaler.
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Citations
19 Claims
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1. An aerosol generating device, comprising:
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a liquid source of a liquid aerosol formulation comprising a high volatility carrier and insulin; a flow passage in fluid communication with the liquid source wherein the flow passage has an outlet which opens into ambient air; a heater disposed to heat the liquid aerosol formulation in a heated portion of the flow passage to 100 to 150°
C. to produce a vapor which exits the flow passage outlet and admixes with ambient air to produce a dry powder aerosol;a power supply; and a controller operable to deliver a dose of the liquid aerosol formulation to the flow passage and control power from the power supply to the heater so as to maintain the heater at a temperature range of 100 to 150°
C. effective to vaporize the liquid aerosol formulation in the flow passage and produce an emitted dose of the dry powder aerosol in ambient air,wherein the aerosol generator is operable to achieve a respirable fraction of at least 70% of the emitted dose. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An aerosol generating device, comprising:
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a liquid source of a liquid aerosol formulation comprising a carrier and insulin; a flow passage in fluid communication with the liquid source wherein the flow passage has an outlet which opens into ambient air; a heater disposed to heat the liquid aerosol formulation in a heated portion of the flow passage to 100 to 150°
C. to produce a vapor which exits the flow passage outlet and admixes with ambient air to produce a dry powder aerosol;a power supply; and a controller operable to deliver a dose of the liquid aerosol formulation to the flow passage and control power from the power supply to the heater so as to maintain the heater at a temperature range of 100 to 150°
C. effective to vaporize the liquid aerosol formulation in the flow passage and produce an emitted dose of the dry powder aerosol in ambient air,wherein the aerosol generator is operable to achieve a respirable fraction of at least 70% of the emitted dose. - View Dependent Claims (18, 19)
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Specification