Catheter having a distal drug delivery unit and method of using same
First Claim
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1. A catheter comprising:
- a hollow, flexible tube having an infusion lumen extending partially therethrough anda drug delivery unit within a distal end of the tube and adapted to be adjacent to a target site in the body, the drug delivery unit comprising;
an actuator in fluid communication with the infusion lumen of the tube, the actuator having an un-expanded inactivated configuration and an expanded activated configuration;
a receptacle in communication with the actuator such that the actuator transmits force to the receptacle in the activated configuration, anda retractable needle in fluid communication with a distal end of the receptacle.
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Abstract
A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.
77 Citations
29 Claims
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1. A catheter comprising:
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a hollow, flexible tube having an infusion lumen extending partially therethrough and a drug delivery unit within a distal end of the tube and adapted to be adjacent to a target site in the body, the drug delivery unit comprising; an actuator in fluid communication with the infusion lumen of the tube, the actuator having an un-expanded inactivated configuration and an expanded activated configuration; a receptacle in communication with the actuator such that the actuator transmits force to the receptacle in the activated configuration, and a retractable needle in fluid communication with a distal end of the receptacle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25)
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21. A catheter comprising:
a hollow, flexible tube comprising an inner shaft having an infusion lumen extending partially therethrough, an outer shaft disposed around the inner shaft, and a drug delivery unit within a distal end of the tube and adapted to be adjacent to a target site in the body, the drug delivery unit comprising; an actuator in fluid communication with the infusion lumen, the actuator having an unexpanded inactivated configuration and an expanded activated configuration; and a receptacle in fluid communication with a retractable needle, the receptacle and actuator in communication with each other, such that the actuator transmits force to the receptacle in the activated configuration.
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22. A method of delivering a therapeutic agent to a target site comprising:
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providing a catheter having a distal end comprising a drug delivery unit; placing a therapeutic agent in the drug delivery unit; and delivering the therapeutic agent to the target site. - View Dependent Claims (23, 24)
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26. A catheter comprising:
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a flexible, hollow tube having a proximal end adapted to receive an infusion material, a distal end adapted to deliver a therapeutic to a patient, and an infusion lumen extending partially therethrough, the tube comprising; a drug delivery unit at the distal end of the tube, the drug delivery unit comprising; an actuator at a distal end of the infusion lumen and in fluid communication therewith, the actuator having an inactivated configuration and an activated configuration; a therapeutic receptacle distal to the actuator, a retractable needle at a distal end of the therapeutic receptacle, wherein the actuator transmits force to the therapeutic receptacle in the activated configuration to deliver a therapeutic to the patient. - View Dependent Claims (27, 28, 29)
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Specification