Deployment system for myocardial cellular material

• US 7,686,799 B2
• Filed: 07/13/2001
• Issued: 03/30/2010
• Est. Priority Date: 07/13/2000
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Lashinski, Robert D, Leonhardt, Howard J
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US10/332,737
• Publication Number:
  US 20040010231A1
• Time in Patent Office: 3,182 Days
• Field of Search: 604/57, 604 59- 61, 604/164.01, 604/264, 604/507, 604/170.03, 604/121, 600 7- 8, 623/8
• US Class Current: 604/507
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: A61M 2025/0086 the needles having bent tips, i.e. the needle distal tips are angled in relation to the longitudinal axis of the catheter
• CPC Class Codes: A61M 2025/0087 Multiple injection needles protruding laterally from the distal tip
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).

Claims

1. A deployment system for a myocardial cellular material, comprising:

a guiding catheter having at least one lumen defined therein;

a needle assembly capable of sliding through the lumen of the guiding catheter, the needle assembly having a lumen defined therein and terminating in a tip, the tip having at least one side, the needle assembly having an opening in the at least one side of the tip disposed in communication with the lumen of the needle assembly so that the myocardial cellular material can be deployed into a myocardial wall from inside the lumen of the needle assembly;

a push rod having a platform disposed at its distal end, the rush rod disposed inside the lumen of the needle assembly; and

an anchor wire disposed axially through the tip and capable of engaging with a portion of the myocardial wall to position the needle assembly relative to the myocardial wall,

wherein the guiding catheter has an outer wall having a distal end, wherein the distal end comprises a sensor and forms an anchor extending frontwardly so as to hold the guiding catheter in a position against the myocardial wall.

2. A deployment system for a myocardial cellular material, comprising:

a guiding catheter having at least one lumen defined therein;

a needle assembly capable of sliding through the lumen of the guiding catheter, the needle assembly having a lumen defined therein and terminating in a tip, the tip having at least one side, the needle assembly having an opening in the at least one side of the tip disposed in communication with the lumen of the needle assembly;

a push rod having a platform disposed at its distal end, the push rod disposed inside the lumen of the needle assembly; and

an anchor wire disposed axially through the tip and capable of engaging with a portion of a myocardial wall to position the needle assembly relative to the myocardial wall,

wherein the guiding catheter has an outer wall having a distal end, wherein the distal end forms an anchor extending frontwardly so as to hold the guiding catheter in a position against the myocardial wall.

3. A method of deploying a myocardial cellular material, comprising:

providing a guiding catheter having at least one lumen defined therein and a needle assembly capable of sliding through the lumen of the guiding catheter, the needle assembly having a lumen defined therein and terminating in a tip, the tip having at least one side, the needle assembly having an opening in the at least one side of the tip disposed in communication with the lumen of the needle assembly so that the myocardial cellular material can be deployed into a myocardial wall from inside the lumen of the needle assembly;

advancing the guiding catheter through a patient'"'"'s body to the myocardial wall and utilizing an anchor wire disposed axially through the tip as a guidewire to engage the myocardial wall and position the needle assembly relative to the myocardial wall, wherein the guiding catheter has an outer wall having a distal end, wherein the distal end forms an anchor extending frontwardly so as to hold the guiding catheter in a position against the myocardial wall;

deploying the needle assembly by inserting the tip of the needle assembly into the myocardial wall to a predetermined depth;

extending a push rod having a platform through the opening in the side of the tip and engaging the platform directly with the myocardial wall;

retracting the platform and inserting the myocardial cellular material into the lumen of the needle assembly; and

deploying the myocardial cellular material into the myocardial wall through the opening in the side of the tip.

4. The method of claim 3, wherein the platform is disposed at the distal end of the push rod.

5. The method of claim 3, wherein the tip of the needle assembly has a point at its distal end.

6. The method of claim 3, wherein the guiding catheter is capable of articulating.

7. The method of claim 3, wherein the needle assembly is capable of articulating.

8. The method of claim 3, wherein the tip has an outer surface with a set of external threads disposed thereon.

9. The method of claim 3, wherein the guiding catheter further comprises a distal end having an anchor hook extending therefrom.

10. The method of claim 3, wherein the guiding catheter further comprises a distal end having a sensor.

11. The method of claim 3, wherein the sensor is an opto-electric sensor.

12. The method of claim 3, wherein the needle assembly has a cradle for holding a charge of the myocardial cellular material, the cradle disposed between the lumen in the needle assembly and the opening in the side of the tip.