Method and apparatus for determining blood oxygen transport
First Claim
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1. An apparatus for measuring diffusion of oxygen across a red blood cell membrane, the apparatus comprising:
- an oxygen level detector, a gas exchange system, and a red blood cell transport system;
the red blood cell transport system being adapted and configured for transporting red blood cells through the gas exchange system and the oxygen level detector;
the gas exchange system being adapted and configured to exchange gasses with the red blood cell;
the oxygen level detector being adapted and configured for detecting oxygen levels in a red blood cell or in fluid surrounding a red blood cell; and
a modular transport system;
the modular transport system comprising a sampling apparatus, a pump, a diffusion apparatus, and a transparent optical system;
the modular transport system being adapted and configured for reversibly coupling to a main body of the apparatus which comprises a gas inlet, a gas outlet, a pump motor, a measuring system, and a control system, wherein the measuring system measures a) an amount of oxygen inside of a red blood cell, b) an amount of oxygen outside of a red blood cell, or c) an amount of oxygen inside and outside of a red blood cell;
the sampling apparatus being adapted and configured for introducing a fluid containing red blood cells into the red blood cell transport system;
the pump being adapted and configured for moving a fluid containing red blood cells into and through the red blood cell transport system, and through the diffusion apparatus and the transparent optical system;
the diffusion apparatus being adapted and configured for providing contact between a gas and a red blood cell; and
the transparent optical system being adapted and configured for providing a generally transparent pathway for light to access the fluid containing red blood cells.
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Abstract
The present invention relates to a method and apparatus for determining blood oxygen transport, and to measure lipid levels by correlating these levels with the rate at which oxygen diffuses through the red blood cell membrane.
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Citations
25 Claims
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1. An apparatus for measuring diffusion of oxygen across a red blood cell membrane, the apparatus comprising:
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an oxygen level detector, a gas exchange system, and a red blood cell transport system; the red blood cell transport system being adapted and configured for transporting red blood cells through the gas exchange system and the oxygen level detector; the gas exchange system being adapted and configured to exchange gasses with the red blood cell; the oxygen level detector being adapted and configured for detecting oxygen levels in a red blood cell or in fluid surrounding a red blood cell; and a modular transport system;
the modular transport system comprising a sampling apparatus, a pump, a diffusion apparatus, and a transparent optical system;the modular transport system being adapted and configured for reversibly coupling to a main body of the apparatus which comprises a gas inlet, a gas outlet, a pump motor, a measuring system, and a control system, wherein the measuring system measures a) an amount of oxygen inside of a red blood cell, b) an amount of oxygen outside of a red blood cell, or c) an amount of oxygen inside and outside of a red blood cell; the sampling apparatus being adapted and configured for introducing a fluid containing red blood cells into the red blood cell transport system; the pump being adapted and configured for moving a fluid containing red blood cells into and through the red blood cell transport system, and through the diffusion apparatus and the transparent optical system; the diffusion apparatus being adapted and configured for providing contact between a gas and a red blood cell; and the transparent optical system being adapted and configured for providing a generally transparent pathway for light to access the fluid containing red blood cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification