Nitric oxide detection

• US 7,687,275 B2
• Filed: 09/04/2006
• Issued: 03/30/2010
• Est. Priority Date: 09/06/2005
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Burdinski, Dirk
• Primary Examiner(s): Gakh; Yelena G.
• Assistant Examiner(s): XU, XIAOYUN
• Application Number:
  US12/065,545
• Publication Number:
  US 20080261322A1
• Time in Patent Office: 1,303 Days
• Field of Search: None
• US Class Current: 436/116
• CPC Class Codes: G01N 33/0037 NOx
• CPC Class Codes: Y02A 50/20 Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters
• CPC Class Codes: Y10T 436/173076 Nitrite or nitrate
• CPC Class Codes: Y10T 436/177692 Oxides of nitrogen
• CPC Class Codes: Y10T 436/20 Oxygen containing
• CPC Class Codes: Y10T 436/204165 Ethanol

Abstract

The present invention relates to a method for amplifying the detected signal in a gas sensor. More specifically, the present invention relates to a method for increasing the concentration of the gas which is being detected in a sample or increasing the concentration of a gas which is directly obtained from the gas in the sample by chemical reaction. The gas which is to be detected is nitric oxide (NO). In particular, the method concerns the selective conversion of NO to NO2 which allows a threefold amplification of the number of analyte molecules in NO trace gas analysis in a single amplification cycle. Subsequent reduction or thermal decomposition of the obtained NO2 can provide NO again, which can again be introduced in a new amplification cycle. Multiple (n) amplification cycles can provide a sensitivity amplification by a factor 3ⁿ. The method can be combined with a multitude of detection methods and tolerates a high humidity. The method is therefore of general use in the analysis of NO from a variety of sources.

Claims

1. A method of determining the concentration of nitric oxide in a gaseous sample, wherein the method comprises the following steps:

a) collecting a gaseous sample containing nitric oxide,

b) exposing the sample to a first substrate to which nitric acid is bound in the presence of water to form nitrogen dioxide by reaction with the nitric oxide,

c) exposing the nitrogen dioxide to a second substrate (17) which is associated with a reducing agent so as to form amplified nitric oxide from any nitrogen dioxide present, and

d) determining the concentration of nitric oxide in the gaseous sample from the amplified nitric oxide-produced in step,

wherein the first and second substrates are comprised in a same substrate.

2. The method according to claim 1, further comprising:

performing in turn one or more sequential exposing steps b) and c) on the gaseous sample resulting in amplified nitric oxide and then measuring the concentration of the resulting amplified nitric oxide or measuring the concentration of the resulting nitrogen dioxide.

3. The method according to claim 1, wherein the concentration of nitric oxide is determined by spectroscopy or gas chromatographic techniques.

4. The method according to claim 1, further comprising between steps a) and b) the step of:

passing the sample through at least one chemical scrubbing unit.

5. The method according to claim 4, wherein the chemical scrubbing unit is an acidic or neutral column.

6. An apparatus for measuring the concentration of nitric oxide in a gaseous sample, the apparatus including the following components arranged in fluid communication:

a vessel for collecting a gaseous sample containing nitric oxide;

a reaction chamber in fluid communication with the vessel containing a first substrate whose surface is able to provide a source of nitric acid and water enabling the formation of nitrogen dioxide after exposition of the sample to the first substrate;

a second substrate, the surface of which includes a reducing agent which forms amplified nitric oxide once in contact with the nitrogen dioxide; and

,

means for determining the concentration of the nitric oxide from the amplified nitric oxide,

wherein the first and second substrates are intimately mixed.

7. The apparatus according to claim 6, wherein the first and second substrates are present as separate layers in the reaction chamber.

12. The apparatus according to claim 6, further comprising:

a fluid connection from and back to the reaction chamber via a valve(s) and a counter.

8. An apparatus for measuring the concentration of nitric oxide in a gaseous sample, the apparatus including the following components arranged in fluid communication:

a vessel for collecting a gaseous sample containing nitric oxide;

a reaction chamber in fluid communication with the vessel, the reaction chamber containing a first substrate, the first substrate being provided with a first substrate surface having a source of nitric acid and water enabling the formation of nitrogen dioxide after exposition of the sample to the first substrate and containing a second substrate, a second substrate surface of the second substrate including a reducing agent capable of forming amplified nitric oxide once in contact with the nitrogen dioxide; and

,

means for determining the concentration of the nitric oxide from the nitrogen dioxide,

wherein the first and second substrates are comprised in a column, and

wherein the first and second substrates are intimately mixed.

9. The apparatus according to claim 8, wherein further comprising:

a chemical scrubbing unit in fluid communications between the vessel and the reaction chamber.

10. The apparatus according to claim 9, wherein the chemical scrubbing unit is an acidic or neutral column.

11. The apparatus according to claim 8, wherein the first and second substrates are arranged in layers.

13. The apparatus according to claim 8, wherein further comprising:

a fluid connection between the reaction chamber and second reaction chamber via valve and counter.