System and method for time-of-flight imaging

• US 7,688,944 B2
• Filed: 07/03/2006
• Issued: 03/30/2010
• Est. Priority Date: 07/01/2005
• Status: Active Grant

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Ritman, Erik Leo
• Primary Examiner(s): Kiknadze; Irakli
• Application Number:
  US11/994,040
• Publication Number:
  US 20090116720A1
• Time in Patent Office: 1,366 Days
• Field of Search: 378/4, 378/19, 378/62, 378/98.8, 250/370.09, 382/132
• US Class Current: 378/62
• CPC Class Codes: A61B 6/00 Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment instruments measuring radiation intensity for application in the field of nuclear medicine, e.g. in vivo counting, G01T1/161; apparatus for taking X-ray photographs G03B42/02
• CPC Class Codes: A61B 6/4092 for producing synchrotron radiation
• CPC Class Codes: A61B 6/484 involving phase contrast X-ray imaging
• CPC Class Codes: G21K 2207/005 Methods and devices obtaining contrast from non-absorbing interaction of the radiation with matter, e.g. phase contrast

Abstract

A system and method for imaging a subject includes a clock that generates a clock signal and a radiation source that directs photons through the subject in response to the clock signal. A detector system is included that detects the photons and a memory module records a time of detection of the photons by the detector system with respect to the clock signal. The system includes a processor that calculates a time of flight (TOF) of the photons from the radiation source to the detector system and compares the TOF to a reference TOF to determine a delay in the TOF attributable to the photons passing trough the subject.

Claims

1. A system for producing diagnostic images comprising:

a clock generating a clock signal;

a radiation source directing photons through a subject to be imaged;

a detector system detecting the photons;

a memory module recording a time of detection of the photons by the detector system with respect to the clock signal; and

a processor calculating a time of flight (TOF) of the photons to the detector system and comparing the TOF to a reference TOF to determine a delay in the TOF attributable to the photons passing trough the subject.

2. The system of claim 1 further comprising means for reconstructing an image of the subject based on the delay in the TOF attributable to the photons passing trough the subject.

3. The system of claim 2 wherein pixel intensity in the reconstructed image is a function of the delay in the TOF attributable to the photons passing trough the subject.

4. The system of claim 1 wherein the radiation source includes a pulsed laser source and electron beam source arranged to collide a laser beam and electron beam together to generate an x-ray pulse directed toward the subject.

5. The system of claim 1 wherein the radiation source includes at least one of a field-emission tube generating x-ray pulses having sub-nanosecond durations and a continuous x-ray source modulated by a modulator arranged between the radiation source and the detector system to modulate the x-rays passing through the subject.

6. The system of claim 1 wherein the processor sums a number of contiguous time slots to generate a frequency histogram and therefrom estimates a time of arrival of the photons at the detector system.

7. The system of claim 1 further comprising an accumulator monitoring the clock signal to generate a metric indicative of the TOF.

8. The system of claim 7 further comprising a trigger coupled to the detector to freeze the accumulator when a photon is detected to generate the metric and provide the metric to the processor.

9. The system of claim 8 wherein the trigger includes a Schmitt trigger.

10. The system of claim 1 wherein the detector includes an LSO crystal coupled to a photomultiplier.

11. The system of claim 1 wherein the detector includes a micro-channel plate image intensifier (MCPI) and a charge coupled device array.

12. The system of claim 11 wherein the MCPI detector includes a plurality of glass capillaries arranged to detect photons traveling transversely to the glass capillaries.

13. A method for producing an image of a subject, the method comprising the steps of:

a) directing photons through a subject from one side of the subject;

b) detecting the location of the photons passing through the subject to another side of the subject opposite the one side of the subject;

c) measuring a time of flight (TOF) of the detected photons; and

d) comparing the TOF of the detected photons to a reference TOF to determine a delay incurred by the photons by passing through the subject; and

e) reconstructing an image of the subject using the location and the delay incurred by the photons passing through the subject determined in steps b) and d).

14. The method of claim 13 wherein step a) includes generating the photons using a positron annihilation source.

15. The method of claim 13 wherein step a) includes generating the photons using at least one of:

a pulsed laser source and electron beam source arranged to collide a laser beam and electron beam together to generate an x-ray pulse directed toward the subject;

a field-emission tube generating x-ray pulses having sub-nanosecond durations directed toward the subject; and

a continuous x-ray source modulated by a modulator arranged between the radiation source and the detector system to modulate the x-rays passing through the subject.

16. The method of claim 13 wherein step e) includes selecting a pixel intensity for each pixel in the reconstructed image based on the delay incurred by the photons passing through the subject.

17. A system for producing diagnostic images comprising:

a radiation source including a positron annihilation source disposed to one side a subject to direct photons through a subject to be imaged;

a reference detector array arranged on the one side of the subject to receive first gamma rays produced by annihilation events;

an image detector array arranged on a side of the subject opposite the one side of the subject to receive second gamma rays produced the annihilation events after the second gamma rays pass through the subject;

a processor calculating a time of flight (TOF) difference between receiving the first gamma rays at the reference detector and the second gamma rays at the image detector; and

means for reconstructing an image of the subject based on the TOF difference.

18. The system of claim 17 wherein pixel intensity in the reconstructed image is a function of the TOF difference.

19. The system of claim 17 wherein the reference detector and the image detector include an LSO crystal coupled to a photomultiplier.

20. The system of claim 17 wherein the reference detector and the image detector includes a micro-channel plate image intensifier (MCPI) and a charge coupled device array.