Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders

• US 7,691,121 B2
• Filed: 12/09/2003
• Issued: 04/06/2010
• Est. Priority Date: 05/01/1998
• Status: Expired due to Term

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Monetti, Richard R., Green, George R. Jr., Chow, Sean L., Sternweiler, Thomas R., Rosenbluth, Robert F., Cox, Brian J.
• Primary Examiner(s): Milano; Michael J
• Assistant Examiner(s): NGUYEN, VI X
• Application Number:
  US10/730,860
• Publication Number:
  US 20040133232A1
• Time in Patent Office: 2,310 Days
• Field of Search: 606/1, 606/108, 606/159, 606191-200, 606/213, 606/110, 606/113, 606/127, 606/128, 606/114, 604/96.01, 604/523
• US Class Current: 606/200
• CPC Class Codes: A61B 17/135 inflatable for measuring blood pressure A61B5/022; inflatable pressure pads A61F5/34
• CPC Class Codes: A61B 17/22032 having inflatable gripping elements balloon catheters A61M25/10
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22044 with a pointed tip
• CPC Class Codes: A61B 2017/22077 with a part piercing the tissue A61B2017/22044 takes precedence
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/22094 for crossing total occlusions, i.e. piercing
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61B 2017/320716 comprising means for preventing embolism by dislodged material
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61M 2025/0042 Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2025/0183 Rapid exchange or monorail catheters

Abstract

Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may included a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

Claims

1. An embolectomy catheter system for removing a blood clot or other embolus from a location within the vasculature of a human or animal subject, the catheter comprising:

a guidewire;

an embolectomy catheter that is advanceable over said guidewire, said embolectomy catheter comprising;

an elongate flexible catheter body having a proximal end, a distal end, an inner tube, and an outer tube terminating proximal to a distal end of the catheter body;

an embolus removal apparatus disposed on the inner tube, the embolus removal apparatus being initially disposed in a collapsed configuration and constrained in said collapsed configuration by a portion of the outer tube; and

a distal tip of the catheter body being located on the inner tube and adapted to pass through a blood clot or other embolus to be removed;

wherein the outer tube is configured to be axially retractable to remove the constraint on the embolus removal apparatus and whereby the embolus removal apparatus is configured to automatically expand from said collapsed configuration to a deployed configuration upon said axial retraction of said outer tube without requiring axial movement or rotation of the guidewire;

said embolus removal apparatus comprising a plurality of resilient members having proximal ends configured to freely slide over said inner tube and distal ends fixed to said inner tube and mid-portions that are configured to extend laterally away from the catheter body when the proximal ends slide over said inner tube as said embolus removal apparatus achieves its deployed configuration, thereby allowing embolic material to become entangled in said resilient members, said resilient members being wrapped around said inner tube in a helical manner when in said collapsed configuration.

2. A system according to claim 1, wherein the outer tube extends distally within a proximal mouth of the distal tip prior to being retracted.

3. A system according to claim 1 wherein a lumen through which the guidewire may pass extends through the inner tube and through the embolus removal device.

4. A system according to claim 1 further comprising a plurality of infusion ports located near said embolus removal apparatus.

5. A system according to claim 1 wherein the embolus removal apparatus expands from its collapsed configuration to its deployed configuration without requiring rotation of any portion of the embolectomy catheter or guidewire.

6. A system according to claim 1 wherein said proximal ends of said resilient members are separated by a marker band that is slidably mounted on said inner tube.

7. A system according to claim 1 wherein said resilient members are biased to have an expanded configuration.

8. A system according to claim 1 wherein said resilient members form an expanded wire nest when said embolus removal apparatus is in said deployed position.