Branched polyalkylene glycols
First Claim
Patent Images
1. A branched polyalkylene glycol represented by formula (I):
-
(R1-Mn-X1)2L(X2—
X3—
R2)q
(I)wherein L represents a nonplanar cyclic group represented by formula (II) or (III);
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure.
-
Citations
17 Claims
-
1. A branched polyalkylene glycol represented by formula (I):
-
(R1-Mn-X1)2L(X2—
X3—
R2)q
(I)wherein L represents a nonplanar cyclic group represented by formula (II) or (III); - View Dependent Claims (2, 3, 4, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
5. A compound, comprising a branched polyalkylene glycol represented by formula (I):
-
(R1-Mn-X1)2L(X2—
X3—
R2)q
(I)wherein L represents a nonplanar cyclic group represented by formula (II) or (III); - View Dependent Claims (6, 7, 8)
-
-
9. A method for treating multiple scleroses which comprises administering, to a patient in need thereof, a compound comprising a branched polyalkylene glycol represented by formula (I):
-
(R1-Mn-X1)2L(X2—
X3—
R2)q
(I)wherein L represents a nonplanar cyclic group represented by formula (II) or (III);
-
Specification