Multi-component pharmaceutical dosage form
First Claim
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1. A multi-component pharmaceutical dosage form which comprises:
- a plurality of sub-units, each sub-unit being selected from the group consisting of;
a linker, a closure cap, a drug substance-containing capsule compartment which is soluble or disintegrable in a patient'"'"'s gastrointestinal environment for release of the drug substance contained in the capsule compartment, and a solid matrix comprising a polymer and containing a drug substance, the polymer being soluble, dispersible or disintegrable in a patient'"'"'s gastrointestinal environment for release of the drug substance contained in the solid matrix, in which the plurality of sub-units are disposed in end-to-end relationship along a line that defines an axial direction, each of the plurality of sub-units including an outer wall surrounding said line, anda plurality of joints, in which each of said plurality of sub-units is joined to at least one other sub-unit by one of the plurality of joints, each joint comprising a plug formed as a unitary part of one respectively joined sub-unit and a socket formed as a unitary part of the other respectively joined sub-unit,wherein the plurality of sub-units includes at least two drug substance containing sub-units each respectively including a socket and at least one linker sub-unit including a pair of plugs on opposed axial ends thereof, each of said pair of plugs being engaged with a respective one of said two drug substance-containing sub-units, andwherein the plurality of joints includes at least two first joints respectively formed between the two drug substance-containing sub-units and the one linker such that the relative axial position between each of the respective two drug substance-containing sub-units and the one linker sub-unit is solely delimited by engaging outer wall axial end parts of the respective two drug substance-containing sub-units and engaging outer wall axial end parts of the one linker sub-unit.
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Abstract
A multi-component pharmaceutical dosage form comprising a plurality of drug substance—containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
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Citations
19 Claims
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1. A multi-component pharmaceutical dosage form which comprises:
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a plurality of sub-units, each sub-unit being selected from the group consisting of;
a linker, a closure cap, a drug substance-containing capsule compartment which is soluble or disintegrable in a patient'"'"'s gastrointestinal environment for release of the drug substance contained in the capsule compartment, and a solid matrix comprising a polymer and containing a drug substance, the polymer being soluble, dispersible or disintegrable in a patient'"'"'s gastrointestinal environment for release of the drug substance contained in the solid matrix, in which the plurality of sub-units are disposed in end-to-end relationship along a line that defines an axial direction, each of the plurality of sub-units including an outer wall surrounding said line, anda plurality of joints, in which each of said plurality of sub-units is joined to at least one other sub-unit by one of the plurality of joints, each joint comprising a plug formed as a unitary part of one respectively joined sub-unit and a socket formed as a unitary part of the other respectively joined sub-unit, wherein the plurality of sub-units includes at least two drug substance containing sub-units each respectively including a socket and at least one linker sub-unit including a pair of plugs on opposed axial ends thereof, each of said pair of plugs being engaged with a respective one of said two drug substance-containing sub-units, and wherein the plurality of joints includes at least two first joints respectively formed between the two drug substance-containing sub-units and the one linker such that the relative axial position between each of the respective two drug substance-containing sub-units and the one linker sub-unit is solely delimited by engaging outer wall axial end parts of the respective two drug substance-containing sub-units and engaging outer wall axial end parts of the one linker sub-unit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A multi-component pharmaceutical dosage form which comprises a plurality of sub-units, each sub-unit being selected from the group consisting of:
- a linker, a closure cap, a drug substance-containing capsule compartment which is soluble or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the capsule compartment, and a solid matrix comprising a polymer and containing a drug substance, the polymer being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the solid matrix, in which dosage form the plurality of sub-units are disposed in end-to-end relationship along a line, and each includes an outer wall surrounding said line, and
a plurality of joints, in which each of said plurality of sub-units is joined to at least one other sub-unit by one of the plurality of joints, each joint comprising a plug forming a unitary part of one of the respectively joined sub-units and a socket formed as a unitary part of the other of the respectively joined sub-units, wherein the plurality of joints includes at least two first joints formed between respective first and second sub-units wherein the relative position between the respective first and second sub-units is solely delimited by engaging outer wall axial end parts of the respective first and second sub-units, wherein the plurality of sub-units includes at least two drug substance-containing capsule compartment sub-units, wherein at least the outer walls of said two drug substance-containing capsule compartment sub-units are formed of polymers, the polymers being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment, and wherein the release characteristics of the outer polymer walls of said two capsule compartment sub-units are different. - View Dependent Claims (16, 17, 18, 19)
- a linker, a closure cap, a drug substance-containing capsule compartment which is soluble or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the capsule compartment, and a solid matrix comprising a polymer and containing a drug substance, the polymer being soluble, dispersible or disintegrable in a patient'"'"'s gastro-intestinal environment for release of the drug substance contained in the solid matrix, in which dosage form the plurality of sub-units are disposed in end-to-end relationship along a line, and each includes an outer wall surrounding said line, and
Specification