Method and device for determining the concentration of a substance in body liquid
First Claim
1. A method for determining a concentration of glucose in at least one of an in-vitro and in-viva specimen containing body liquid, the method comprising:
- arranging a first electrode at said specimen, wherein the first electrode is electrically insulated from the specimen by a cover layer, and wherein the first electrode is arranged on a first side of a electrically insulating substrate between the substrate and the cover layer;
applying a modulated electrical voltage to the first electrode for generating a modulated field in the specimen; and
measuring at least one parameter depending on a response of the specimen to the field and determining the concentration therefrom,wherein the first electrode forms part of a resonant circuit having a resonance frequency and wherein the resonant circuit is operated substantially at the resonance frequency.
7 Assignments
0 Petitions
Accused Products
Abstract
For measuring the concentration of a substance in body fluid, such as the glucose level in blood or tissue, a strip electrode (18) and a ring electrode (19) are arranged at the specimen. The ring electrode (19) is in direct electrical contact with the specimen while the strip electrode (18) is electrically insulated therefrom. The strip electrode (18) is arranged parallel to an arm or a leg for obtaining a large interaction length. The electrodes (18, 19) form a capacitor in a resonant circuit. A modulated voltage in the MHz range close to or at the resonance frequency is applied to the electrodes and the response of the body fluid is measured. This design allows a measurement of high accuracy.
63 Citations
27 Claims
-
1. A method for determining a concentration of glucose in at least one of an in-vitro and in-viva specimen containing body liquid, the method comprising:
-
arranging a first electrode at said specimen, wherein the first electrode is electrically insulated from the specimen by a cover layer, and wherein the first electrode is arranged on a first side of a electrically insulating substrate between the substrate and the cover layer; applying a modulated electrical voltage to the first electrode for generating a modulated field in the specimen; and measuring at least one parameter depending on a response of the specimen to the field and determining the concentration therefrom, wherein the first electrode forms part of a resonant circuit having a resonance frequency and wherein the resonant circuit is operated substantially at the resonance frequency. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. A device for determining a concentration of glucose in at least one of an in-vitro and in-vivo specimen containing body liquid, the device comprising:
-
an electrically insulating substrate; a first electrode covered by a cover layer of insulating material, wherein the first electrode is arranged on a first side of the substrate between the substrate and the cover layer; a signal source connected to the first electrode and configured to apply a modulated electrical voltage to the first electrode to generate an electric field in the specimen; a measuring circuit configured to measure at least one parameter depending on a response of the specimen to the field; a data processor configured to determine the concentration from the parameter; and a second electrode arranged on the substrate, wherein the signal source is connected to and configured to apply the modulated electrical voltage between the first and the second electrodes, wherein the second electrode comprises a top electrode layer arranged on the first side of the substrate, said top electrode layer being arranged, at least in part, around the first electrode, and wherein the second electrode further comprises a bottom electrode layer arranged on a second side of the substrate, said bottom electrode layer having a larger extension than said top electrode layer. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
-
-
23. A device for determining a concentration of a substance in body liquid of a human body, the device comprising:
-
an elongate first electrode having a width substantially smaller than a length; a band for fixing the first electrode to at least one of an arm and a leg of a body with a longitudinal axis of the first electrode being substantially parallel to the at least one arm and leg; a signal source connected to the first electrode applying a modulated electrical voltage to the first electrode for generating a modulated field in the specimen; a measuring circuit for measuring at least one parameter depending on a response of the specimen to the field; and a data processor determining the concentration from the parameter. - View Dependent Claims (24, 25, 26, 27)
-
Specification