Irritable bowel syndrome treatment
First Claim
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1. A method for treating diarrhea dominant irritable bowel syndrome in a patient comprising:
- positioning an electrode on a vagus nerve below a vagal innervation of a heart of the patient, with the nerve innervating at least one of a plurality of alimentary tract organs; and
treating the patient'"'"'s diarrhea dominant irritable bowel syndrome by applying an electrical signal to the electrode with the signal selected toa) at least in part, down-regulate neural activity on the vagus nerve,b) allow partial restoration of nerve activity upon discontinuation of the electrical signal,c) have a frequency of at least 500 Hz, andd) reduce pancreatic output via inhibition of pancreo-biliary output;
and wherein the signal is not applied in response to a sensed event.
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Abstract
At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
196 Citations
13 Claims
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1. A method for treating diarrhea dominant irritable bowel syndrome in a patient comprising:
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positioning an electrode on a vagus nerve below a vagal innervation of a heart of the patient, with the nerve innervating at least one of a plurality of alimentary tract organs; and treating the patient'"'"'s diarrhea dominant irritable bowel syndrome by applying an electrical signal to the electrode with the signal selected to a) at least in part, down-regulate neural activity on the vagus nerve, b) allow partial restoration of nerve activity upon discontinuation of the electrical signal, c) have a frequency of at least 500 Hz, and d) reduce pancreatic output via inhibition of pancreo-biliary output; and wherein the signal is not applied in response to a sensed event. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification