Acoustic method for measuring a signal propagation time in a medical liquid and device for using this method

• US 7,694,565 B2
• Filed: 07/15/2004
• Issued: 04/13/2010
• Est. Priority Date: 08/22/2003
• Status: Expired due to Fees

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Inventors: Metzner, Klaus, Koerdt, Franz-Wilhelm, Kuhn, Alexander, Nikolic, Dejan, Scheunert, Peter
• Primary Examiner(s): SAINT SURIN, JACQUES M
• Application Number:
  US10/568,830
• Publication Number:
  US 20070186624A1
• Time in Patent Office: 2,098 Days
• Field of Search: 73/530.1, 735/97, 736/02, 736/09, 736/17, 738/612.7, 738/612.8, 738/612.9, 735/98
• US Class Current: 73/597
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: G01H 5/00 Measuring propagation velocity of ultrasonic, sonic or infrasonic waves , e.g. of pressure waves
• CPC Class Codes: G01N 2291/02466 Biological material, e.g. blood
• CPC Class Codes: G01N 2291/02818 Density, viscosity
• CPC Class Codes: G01N 29/024 by measuring propagation velocity or propagation time of acoustic waves
• CPC Class Codes: G01N 29/4427 with stored values, e.g. threshold values

Abstract

This invention relates to the field of signal transit time sensors, in particular sensors based on ultrasonic transit times. Existing electronic control circuits for such transit time sensors for measurements on medical liquids, in particular blood, are extremely complex or their time resolution is limited. However, the present invention makes use of a simple measurement technique which cannot be used directly at first for the time resolution to be achieved. In this method, an ordinary sampling method is used to detect the received signal (12). An oscillator-like received signal (12) generated by an emitted step-like signal is first sampled during a half-period (14, 15) and is checked with the help of a selection criterion. Only when the result of this check is positive is at least one interpolated or extrapolated contact point (20, 21) of the received signal (12) with a resting level (11) determined in a received signal-time diagram with the help of which the signal transit time or the change in signal transit time is determined.

Claims

1. A method of measuring a signal transit time in a medical liquid required by a signal to pass through a measurement zone from an ultrasonic transmitter (2) to an ultrasonic receiver (3), in which a line carrying the medical liquid is arranged in the measurement zone, comprising

emitting a step-like signal (10) with the ultrasonic transmitter (2) such that the step-like signal (10) passes through the measurement zone, resulting in an oscillation-like received signal (12) oscillating about a resting level (11) on the ultrasonic receiver (3), the received signal being sampled at regular intervals Δ

t and detected,

checking the oscillator-like received signal (12) on the basis of a selection criterion at least during a half-period (14, 15) to determine whether the oscillator-like received signal (12) is the received signal produced by the step-like signal (10), and

when the result of this check is positive, determining the signal transit time or the change in the signal transit time with an interpolated or extrapolated contact point (20, 21) of the oscillator-like received signal (12) with the resting level (11) in a received signal-time diagram.

2. The method according to claim 1, wherein for determining the signal transit time, the point used as the interpolated or extrapolated contact point is the point (21) in the received signal-time diagram at which the oscillator-like received signal (12) at the beginning of the first half-period (14) differs from the resting level (11).

3. The method according to claim 1, wherein for determining the change in signal transit time, the point (20) in the received signal-time diagram at which the oscillator-like received signal (12) intersects the resting level (11) after the first half-period (14) is determined as the interpolated or extrapolated contact point.

4. The method according claim 1, wherein an area enclosed between the oscillator-like received signal (12) and the resting level (11) is determined during the half-period (14).

5. The method according to claim 4, wherein the area determined is compared with a reference value as the selection criterion.

6. The method according to claim 4, wherein the subsequent half-period (15) is sampled and detected, and the area enclosed between the oscillator-like received signal (12) and the resting level (11) is determined during the subsequent half-period (15).

7. The method according to claim 6, wherein the area enclosed between the oscillator-like received signal (12) and the resting level (11) is compared with a reference value as the selection criterion during a subsequent half-period (15).

8. The method according to claim 1, wherein an extreme value (18) of the oscillator-like received signal (12) is determined during the half-period (14) and is compared with a reference value.

9. The method according to claim 8, wherein the subsequent half-period (15) is sampled and detected and an extreme value (19) of the oscillator-like received signal (12) is determined during the subsequent half-period (15) and compared with a reference value.

10. The method according to claim 1, wherein the duration of one or more half-periods (14, 15) of the oscillator-like received signal (12) is determined as the selection criterion and is compared with a reference value.

11. The method according to claim 1, wherein the resting level (11) is determined as the average of received signal samples (13) preceding the half-period (14).

12. The method according to claim 4, wherein the area determined is analyzed as a measure of the attenuation of the signal.

13. The method according to claim 1, wherein the medical liquid is blood, dialysis liquid or an infusion liquid.

14. A device for use of the method according to claim 1, comprising

an ultrasonic transmitter (2) for emitting the step-like signal (10),

an ultrasonic receiver (3) which is separated from the ultrasonic transmitter (2) by the measurement zone for delivering a received signal (12) which oscillates about a resting level (11) as the response to the step-like (10) signal passing through the measurement zone,

a line (1) arranged in the measurement zone carrying a medical liquid,

an analyzer unit (6) that is connected to the ultrasonic transmitter (2) and the ultrasonic receiver (3),

the analyzer unit (6) receiving synchronized signals for sending the transmission signal and having a sampling device for sampling and storing the oscillator-like received signal (12) at regular intervals Δ

t,

the analyzer unit (6) being configured for checking on the oscillator-like received signal (12) on the basis of a selection criterion at least during a half-period (14, 15) to determine whether the signal is the received signal caused by the step-like signal (10), and

if the result of the test is positive, for determining the signal transit time or the change in the signal transit time of an interpolated or extrapolated contact point (20, 21) of the oscillator-like received signal (12) with a resting level (11) in a received signal-time diagram.

15. The device according to claim 14, wherein the analyzer unit (6) is configured for analyzing at least one of the signal transit time and the change in signal transit time as a measure of at least one of the composition and the change in composition of the medical liquid on the basis of stored information.

16. The device according to claim 14, wherein the medical liquid is blood, dialysis liquid or an infusion liquid.

17. The device according to claim 16, wherein the device is a blood volume sensor.

18. The device according to claim 17, wherein the device is the blood volume sensor and an air detection sensor.