Controlled vapor deposition of biocompatible coatings over surface-treated substrates
First Claim
1. A method converting a surface of a siloxane substrate from a hydrophobic nature, where a water droplet contact angle is in a range of about 90 degrees to about 130 degrees, to a hydrophilic nature, where said water droplet contact angle ranges from about 5 degrees to about 50 degrees, wherein said surface of said siloxane substrate is treated with ozone in the presence of UV radiation, wherein a biocompatible vapor-deposited coating is applied over said siloxane substrate treated with ozone in the presence of UV radiation, and where said biocompatible coating includes at least one organic functional layer, wherein said method comprises the steps of:
- a) exposing said surface of said siloxane substrate to an ozone-comprising gas in a processing chamber, wherein UV radiation is applied during exposure of said siloxane surface to said ozone-comprising gas;
b) subsequently, without exposure of said ozone and UV radiation treated siloxane substrate to ambient conditions which contaminate or react with said treated surface, exposing said surface to a silicon chloride containing vapor in the presence of moisture, to form a hydrophilic silicon oxide layer on said treated siloxane substrate surface; and
c) subsequently, without exposure of said hydrophilic silicon oxide layer to ambient conditions which contaminate or react with said hydrophilic silicon oxide layer, exposing said silicon oxide layer to a functionalized silane precursor vapor to form a layer selected from the group consisting of a monolayer, a self-aligned monolayer, and a polymerized cross-linked layer.
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Abstract
We have developed an improved vapor-phase deposition method and apparatus for the application of layers and coatings on various substrates. The method and apparatus are useful in the fabrication of biofunctional devices, Bio-MEMS devices, and in the fabrication of microfluidic devices for biological applications. In one important embodiment, a siloxane substrate surface is treated using a combination of ozone and UV radiation to render the siloxane surface more hydrophilic, and subsequently a functional coating is applied in-situ over the treated surface of the siloxane substrate.
56 Citations
21 Claims
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1. A method converting a surface of a siloxane substrate from a hydrophobic nature, where a water droplet contact angle is in a range of about 90 degrees to about 130 degrees, to a hydrophilic nature, where said water droplet contact angle ranges from about 5 degrees to about 50 degrees, wherein said surface of said siloxane substrate is treated with ozone in the presence of UV radiation, wherein a biocompatible vapor-deposited coating is applied over said siloxane substrate treated with ozone in the presence of UV radiation, and where said biocompatible coating includes at least one organic functional layer, wherein said method comprises the steps of:
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a) exposing said surface of said siloxane substrate to an ozone-comprising gas in a processing chamber, wherein UV radiation is applied during exposure of said siloxane surface to said ozone-comprising gas; b) subsequently, without exposure of said ozone and UV radiation treated siloxane substrate to ambient conditions which contaminate or react with said treated surface, exposing said surface to a silicon chloride containing vapor in the presence of moisture, to form a hydrophilic silicon oxide layer on said treated siloxane substrate surface; and c) subsequently, without exposure of said hydrophilic silicon oxide layer to ambient conditions which contaminate or react with said hydrophilic silicon oxide layer, exposing said silicon oxide layer to a functionalized silane precursor vapor to form a layer selected from the group consisting of a monolayer, a self-aligned monolayer, and a polymerized cross-linked layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification